A5008200725- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Autophagy in Disease and Therapy
- Skin and Cellular Biology Research
- Cancer and Skin Lesions
- Inflammatory Bowel Disease
- Cancer Cells and Metastasis
- Hair Growth and Disorders
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- RNA Research and Splicing
- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Hydrogen's biological and therapeutic effects
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Wound Healing and Treatments
- Ginseng Biological Effects and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related gene regulation
- Wind Turbine Control Systems
- Digestive system and related health
Wenzhou Medical University
2021-2025
Dongyang People's Hospital
2021-2025
Children's Hospital of Philadelphia
2020-2024
University of Pennsylvania
2023
Philadelphia University
2022-2023
Tianjin University of Traditional Chinese Medicine
2015-2022
University of California, Irvine
2018-2021
China Agricultural University
2017-2020
Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during can help uncover the principles of homeostasis disease including colorectal cancer. Here we show that miR-31 drives proliferation, protects ISCs against apoptosis, both in response ionizing radiation injury. Furthermore, has oncogenic properties, promoting tumorigenesis. Mechanistically, acts balance input from Wnt, BMP, TGFβ signals...
Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with the majority cases initiated by inactivation APC tumour suppressor. This results in constitutive activation canonical WNT pathway transcriptional effector ß-catenin, along induction feedback inhibitors, including extracellular palmitoleoyl-protein carboxylesterase NOTUM which antagonises WNT-FZD receptor-ligand interactions. Here, we sought to evaluate effects activity on CRC as function driver mutation landscape.
Naoxintong capsule (NXT) is a commercial medicinal product approved by the China Food and Drug Administration which used in treatment of stroke coronary heart disease. However, research on composition mechanism NXT still lacking. Our aimed to identify absorbable components, potential targets, associated pathways with network pharmacology method. We explored chemical compositions based UPLC/Q‐TOF‐MS. Then, we five principles drug absorption ingredients. The databases PharmMapper, Universal...
Sleep disorder is a common comorbidity in chronic obstructive pulmonary disease (COPD). We aim to explore the potential association between daily sitting time (DST), leisure-time physical activity (LTPA) and sleep disorders COPD patients. The sleep, LTPA, DST data of participants with were extracted from National Health Nutrition Examination Survey (NHANES) portal (2007-2012), basing on Global Physical Activity Questionnaire. t-test, Mann-Whitney test, or chi-square test employed analyze...
Phagocytosis is the necessary first step to sense foreign microbes or particles and enables activation of innate immune pathways such as inflammasomes. However, molecular mechanisms underlying how phagosomes modulate inflammasome activity are not fully understood. We show that in murine dendritic cells (DCs), lysosomal histidine/peptide solute carrier transporter SLC15A4, associated with human inflammatory disorders, recruited required for optimal after infectious sterile stimuli. Dextran...
Previous study showed that circular RNA Absent-Small-Homeotic-2--Like protein (circASH2L) was higher in rheumatoid arthritis (RA) patients. However, the roles and mechanisms of circASH2L RA progression remain unclear.Levels analysis conducted using western blot qRT-PCR. The proliferation, apoptosis, cell cycle progression, migration, invasiveness, inflammation fibroblast-like synoviocytes (RA-FLSs) were determined via MTT, flow cytometry, blot, transwell, ELISA assays.CircASH2L knockdown...
Calorie restriction is associated with enhanced intestinal regeneration after irradiation, but the requirement of autophagy for this process not known. Our data support premise that epithelial required regenerative benefit calorie restriction. We also report luminal levels primary bile acid glycocholic are modulated by cell during direct effects on stem function.
Long-term nitroglycerin (NTG) therapy causes tolerance to its effects attributing increased oxidative stress and endothelial dysfunction. Shenmai injection (SMI), which is clinically used treat cardiovascular diseases, consists of two herbal medicines, Ginseng Rubra Ophiopogonjaponicas, reported have antioxidant effects. The present study was designed investigate the potential preventive on development nitroglycerin-induced tolerance. involves both in vivo vitro experiments We examined...
Intestinal epithelial transit-amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite these cells' critical roles in homeostasis disease, few studies have described genes that cell function. We report RNA methyltransferase-like 3 (METTL3) is survival of the murine small intestine. Transit-amplifying death after METTL3 deletion was associated with crypt...
Hairlessness is usually a rare trait in pigs; however, this study, we found hairless (HR) pigs at relatively high frequency 1 pig herd. We observed that, the lower hair shaft density of HR could be mainly attributed to follicle density, and during embryonic period, d 39‐45 were critical stage for formation follicle. In regard, 41 gestation was particularly important point. Hair morphogenesis occurring an early embryo development similar humans mice. Further analyses association studies based...
Abstract Background Defining epithelial cell contributions to inflammatory bowel disease (IBD) is essential for the development of much needed therapies barrier repair. Children with very early onset (VEO)-IBD have more extensive, severe, and refractory than older children adults IBD and, in some cases, defective function. We therefore evaluated functional transcriptomic differences between pediatric (VEO onset) non-IBD epithelium using 3-dimensional, biopsy-derived organoids. Methods...
Intestinal epithelial transit amplifying cells are essential stem progenitors required for intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage from radiation and chemotherapy. Despite critical roles in homeostasis disease, few studies have described genes that cell function. We report the RNA methyltransferase, METTL3, is survival of murine small intestine. Transit death after METTL3 deletion was associated with crypt villus atrophy, loss absorptive...
The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative stem cells are that survive tissue injury divide to re-establish the epithelium. Prior studies have shown autophagic state as functional marker facultative cells, but regulatory mechanisms not known. current study evaluated post-transcriptional regulation autophagy an important factor for cell regeneration. We composition, vesicle content,...
ABSTRACT Cytokines mediating epithelial and immune cell interactions modulate mucosal healing-a process that goes awry with chronic inflammation as in inflammatory bowel disease. TNFSF13 is a cytokine important for B maturation function, but roles putative contribution to disease are poorly understood. We evaluated functional consequences of novel monoallelic variant using biopsies, tissue-derived colonoids induced pluripotent stem (iPSC)-derived colon organoids. exhibited >50% reduction...
Interstitial lung disease (ILD) is a severe manifestation of rheumatoid arthritis (RA), which characterized by low survival time post-diagnosis. Thus, it important to explore the role gene regulation related with ILD.Constructed RA-ILD-related long chain noncoding RNA - messenger (lncRNA-mRNA) network (ILD-LMN), based on ILD- and RA-related genes. We analyzed topological properties resulting network.The results for modularization functional analysis showed that ILD-LMN performed basic...