A5088413788- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Microbial Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Medicinal Plants and Bioactive Compounds
- Caveolin-1 and cellular processes
- Alcohol Consumption and Health Effects
- Chemical synthesis and pharmacological studies
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Mycobacterium research and diagnosis
- Berberine and alkaloids research
- Magnolia and Illicium research
- Bioactive Natural Diterpenoids Research
- Cancer, Hypoxia, and Metabolism
Tianjin University of Traditional Chinese Medicine
2016-2021
Atherosclerosis is a multifactorial vascular disease triggered by disordered lipid metabolism, characterized chronic inflammatory injury, and initiated endothelial dysfunction. Berberine the main active alkaloid of herbal medicine Coptidis Rhizoma (Huanglian). Notably, berberine has been shown to have beneficial effects against atherosclerosis. However, mechanisms in preventing atherosclerosis are still unclear. This study aimed at investigating protecting aorta ameliorating apolipoprotein...
Long-term nitroglycerin (NTG) therapy causes tolerance to its effects attributing increased oxidative stress and endothelial dysfunction. Shenmai injection (SMI), which is clinically used treat cardiovascular diseases, consists of two herbal medicines, Ginseng Rubra Ophiopogonjaponicas, reported have antioxidant effects. The present study was designed investigate the potential preventive on development nitroglycerin-induced tolerance. involves both in vivo vitro experiments We examined...
Naoxintong capsule (NXT) is one of the most prevalent Traditional Chinese Medicine formulations in treatment coronary heart disease (CHD), yet action pharmacodynamic components remains unclear.To determine basis by which NXT may be effective CHD.The protective effect (0.01-100 μg/mL) on 293 T and hy926 cells was determined MTT assay for 24 h. Afterwards, to investigate material anti-inflammatory antioxidant effects, based previous UPLC/Q-TOF analysis, were divided into control (treated with...
Shenxiang Suhe Pill (SXSHP), a Chinese medicine formula, is widely used in clinic to treat coronary heart disease (CHD). However, due the complex composition of SXSHP, its underlying mechanisms and pharmacodynamic properties are still unknown. In this paper, we try define compounds SXSHP by dual-screening active ingredients with anti-inflammation antioxidant effects predict multi-target-pathway CHD therapy using network pharmacology. The chemical constituents were analyzed UPLC/Q-TOF. Then,...
补骨脂是临床常用的补益类中药，具有补肾壮阳、补脾健胃的功能。补骨脂生品性燥，具有较强的肝毒性，因此临床使用上多以其炮制品为主。补骨脂炮制最初见于《雷公炮炙论》，后世医药学家在医疗实践中继承并发展了雷公炮制法。在课题组前期研究的基础上，结合2020年之前发表的与补骨脂相关的文献，通过炮制前后化学成分的变化分析补骨脂“雷公炮制法”的减毒机制，发现雷公法炮制过程中补骨脂毒性成分(异)补骨脂苷转化为活性成分(异)补骨脂素，阐述了雷公炮制法减毒的科学内涵，为进一步优化补骨脂炮制工艺提供科学依据。
Objective: Side effects caused by chemotherapy usually lead to decline in the quality of life for patients and even have discontinued because intolerance. The immunosuppression has been paid more attention recent years, ginsenosides Rg3 (Rg3) suggested contribute enhance immune function.