A5100381366- Reproductive tract infections research
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive System and Pregnancy
- Bacteriophages and microbial interactions
- Urinary Tract Infections Management
- Clostridium difficile and Clostridium perfringens research
- Pediatric health and respiratory diseases
- Cervical Cancer and HPV Research
- Immune Response and Inflammation
- Remote Sensing and Land Use
- RNA and protein synthesis mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Genomics and Phylogenetic Studies
- Plant Gene Expression Analysis
- Genomics, phytochemicals, and oxidative stress
- Enterobacteriaceae and Cronobacter Research
- Global trade and economics
- Plant Stress Responses and Tolerance
- RNA Interference and Gene Delivery
- Plant-Microbe Interactions and Immunity
- Plant nutrient uptake and metabolism
- Soil Carbon and Nitrogen Dynamics
- Environmental and Agricultural Sciences
- Trace Elements in Health
University of New England
2020-2025
Wuhan Polytechnic University
2020-2025
Xi'an Jiaotong University
2014-2024
Zhejiang A & F University
2021-2024
National Institutes of Health
2018-2024
National Institute of Allergy and Infectious Diseases
2020-2024
Soochow University
2017-2024
First Affiliated Hospital of Soochow University
2017-2024
Institute of Forest Ecology, Environment and Protection
2017-2024
Chinese Academy of Forestry
2017-2024
Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant growth, development, and responses to various environmental stimuli. We demonstrate that MKK9, an MKK, is upstream activator of the MPKs MPK3 MPK6 both vitro planta. Expression active MKK9 transgenic plants induces synthesis ethylene camalexin through activation endogenous kinases. As a consequence, transcription multiple genes responsible for biosynthesis, responses, biosynthesis coordinately...
Drought is one of the major factors limiting global maize production. Exposure to long-term drought conditions inhibits growth and leads yield losses. Although several drought-responsive genes have been identified functionally analyzed, mechanisms underlying responses water recovery treatments not fully elucidated. To characterize how seedling respond stress at transcriptional level, we analyzed physiological differentially expressed (DEGs) in inbred line B73 under deficit conditions.The...
The polymixin colistin is a "last line" antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as plasmid-mediated resistance mechanism in human and animal Enterobacteriaceae, with wide geographical distribution many producer strains resistant to multiple other antibiotics. encodes membrane-bound enzyme catalysing phosphoethanolamine transfer onto bacterial lipid A. Here we present crystal structures revealing MCR-1 periplasmic, catalytic...
A whole genome scale proteome array consisting of 908 open reading frames encoded in Chlamydia trachomatis and plasmid was used to profile anti-chlamydial Ab responses. total 719 chlamydial proteins recognized by one or more antisera from 99 women urogenitally infected with C. trachomatis. Revealing such a large ANTIGENome humans might partially be attributed the significantly improved detection sensitivity assay because both linear conformation-dependent Abs were detected assay....
Abstract Camalexin, a major phytoalexin in Arabidopsis thaliana, consists of an indole ring and thiazole ring. The is produced from Trp, which converted to indole-3-acetonitrile (IAN) by CYP79B2/CYP79B3 CYP71A13. Conversion Cys(IAN) dihydrocamalexic acid subsequently camalexin catalyzed CYP71B15. Recent studies proposed that Cys derivative, not itself, the precursor conjugates with IAN. nature derivative how it IAN forms remain obscure. We found protein accumulation multiple glutathione...
MyD88, a key adaptor molecule required for many innate immunity receptor-activated signaling pathways, was evaluated in Chlamydia muridarum urogenital tract infection model. Compared with wild-type mice, MyD88 knockout (KO) mice failed to produce significant levels of inflammatory cytokines the genital during first week chlamydial infection. KO developed Th2-dominant whereas Th1/Th17-dominant immune response after Despite insufficient production early and lack adaptive immunity, appeared be...
Plasmid-free Chlamydia trachomatis and muridarum fail to induce severe pathology. To evaluate whether the attenuated pathogenicity is due insufficient infection or inability of plasmidless chlamydial organisms trigger pathological responses, we compared plasmid-competent plasmid-free C. infections in 5 different strains mice. All developed hydrosalpinx following intravaginal inoculation with plasmid-competent, but not plasmid-free, muridarum. The lack induction by correlated significantly...
We investigated antimicrobial resistance trends and characteristics of ESBL-producing Escherichia coli isolates from pets whether this correlates with antibiotic usage in the clinic. Clinical samples containing E. diseased cats dogs were screened for sensitivity associated genotypic features. identified 127 1886 (n = 1565) 321) majority urinary tract infections 108, 85%). High rates observed β-lactams fluoroquinolones to > 3 classes (MDR) increased 67% 2012 75% 2017 (P < 0.0001). This was...
Purpose: Keratin 17 (KRT17) is a 48 KDa type I intermediate filament, which mainly expressed in epithelial basal cells. KRT17 has been shown to be overexpressed many malignant tumors and play an important role the occurrence development of tumors. Therefore, this study explored underlying mechanism non-small cell lung cancers (NSCLC). Methods: expression its correlations with clinicopathological factors were examined cancer tissues by immunohistochemistry. The prognosis value NSCLCs was...
The wide dissemination of New Delhi metallo-β-lactamase genes (blaNDM) has resulted in the treatment failure most available β-lactam antibiotics, with IncX3-type blaNDM-5-carrying plasmids recognised as having spread worldwide. In China, bacteria carrying these are increasingly being detected from diverse samples, including hospitals, communities, livestock and poultry, environment, suggesting that IncX3 becoming a vital vehicle for blaNDM dissemination. To elucidate fitness cost on...
ABSTRACT Human antibody recognition of Chlamydia trachomatis plasmid-encoded Pgp3 protein is dependent on the native conformation Pgp3. The structural basis for dependence and function remain unknown. Here, we report that trimerization required by human antibodies. In a polyacrylamide gel, purified from bacterial expression system migrated as stable trimers were dissociated into monomers only treatment with urea or sodium dodecyl sulfate (SDS) but not nonionic detergents. antibodies...
Despite the abundance of phosphorus in soil, very little is available as phosphate (Pi) for plants. Plants often experience low Pi (LP) stress. Intensive studies have been conducted to reveal mechanism used by plants deal with LP; however, sensing and signal transduction pathways are not fully understood. Using in-gel kinase assays, we determined activities MPK3 MPK6 Arabidopsis thaliana seedlings under both LP Pi-sufficient (Murashige Skoog, MS) conditions. MKK9 mutant transgenic crossed...
ABSTRACT The recent emergence of a transferable colistin resistance mechanism, MCR-1, has gained global attention because its threat to clinical treatment infections caused by multidrug-resistant Gram-negative bacteria. However, the possible transmission route mcr-1 among Enterobacteriaceae species in settings is largely unknown. Here, we present comprehensive genomic analysis Escherichia coli isolates collected hospital Hangzhou, China. We found that -carrying from and feces inpatients...
Abstract To investigate the prevalence of recently emerging colistin resistance gene mcr-1 in Enterobacteriaceae among companion animals, we examined 566 isolates collected from cats and dogs Beijing, China, during 2012–2016. Of these isolates, 49 (8.7%) were mcr-1–positive.