A5100429739- Neuroblastoma Research and Treatments
- Antibiotic Resistance in Bacteria
- Plant Pathogens and Fungal Diseases
- Protein Degradation and Inhibitors
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Metabolism and Applications
- Food Quality and Safety Studies
- Insect Utilization and Effects
- Phytase and its Applications
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Enzyme Production and Characterization
- Epigenetics and DNA Methylation
- GABA and Rice Research
- Cancer Research and Treatments
- Dietary Effects on Health
- Animal Nutrition and Physiology
- melanin and skin pigmentation
- Antimicrobial agents and applications
- Vitamin C and Antioxidants Research
- Economics of Agriculture and Food Markets
- Genetics and Neurodevelopmental Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
- Plant and Biological Electrophysiology Studies
Jiangxi University of Traditional Chinese Medicine
2016-2025
Central University of Finance and Economics
2024
Wuhan University
2014-2023
Wuhan Botanical Garden
2022-2023
Heilongjiang University of Chinese Medicine
2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2023
Heilongjiang Academy of Sciences
2023
Jiangxi Academy of Agricultural Sciences
2023
Animal Science Research Institute
2023
Gansu Agricultural University
2023
Abstract Efforts to therapeutically target EZH2 have generally focused on inhibition of its methyltransferase activity, although it remains less clear whether this is the central mechanism whereby promotes cancer. In current study, we show that directly interacts with both MYC family oncoproteins, and MYCN, their stabilization in a methyltransferase-independent manner. By competing against SCF FBW7 ubiquitin ligase bind counteracts FBW7-mediated MYC(N) polyubiquitination proteasomal...
Abstract Macrophages play an important role in the development of life-threatening sepsis, which is characterized by multiorgan dysfunction, through their ability to produce inflammatory cytokines. Carvacrol a phenolic compound that has been confirmed possess strong anti‑inflammatory activity. In this study, we mainly investigated effect carvacrol on lipopolysaccharide (LPS)-induced macrophage proinflammatory responses and endotoxic shock. The results showed significantly reduced mouse body...
MYCN amplification in neuroblastoma leads to aberrant expression of oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how coordinates transcription elongation meet productive and machinery represents MYCN-driven vulnerability remain be identified. We conducted a targeted screen factors identified the super complex (SEC) as unique MYCN-amplified neuroblastomas. directly EAF1 recruits SEC enhance processive elongation. Depletion or AFF1/AFF4, another core...
T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of progenitors. The major challenges in treatments T-ALL dose-limiting toxicities chemotherapeutics drug resistance. Despite important progress deciphering genomic landscape T-ALL, translation these findings into effective targeted therapies remains largely unsuccessful. New agents with significant antileukemic efficacy less toxicity urgent need. We...
Previous studies found that rutin can improve production performance of sheep and dairy cows. However, it is not clear whether has similar effects in goats. Hence, the aim this experiment was to study supplementation on growth performance, slaughter serum parameters, meat quality Nubian A total 36 healthy ewes were randomly divided into three groups. Goats fed basal diet supplemented with 0 (R0), 25 (R25), 50 (R50) mg per kg diet. The goats had no significant difference among pH45min...
Allergic airway inflammation is a universal disease induced by inhaling allergens. Published data show that RNF128, an E3 ligase, promotes Th2 activation in the OVA-induced asthma model. Recent advances have shown group 2 innate lymphoid cells (ILC2s) produce cytokines IL-5 and IL-13 to mediate type immune response. However, whether RNF128 regulates ILC2-dependent allergic lung remains unclear. In this study, we observed greater expression of ligase ILC2s than other cells. deficiency caused...
During the outbreak of novel coronavirus disease (COVID-19), Chinese government took a series public health measures to tackle and recommended six traditional medicine (TCM) evolved formulas, collectively referred as “3-drugs-3-formulas”, for treatment. In this prospective article, we will discuss how these formulas from TCM what their underlying mechanisms actions may be by evaluating historical usage component potential targeted pathways individual herbs used STAR (signal transduction...
Background Diabetic retinopathy (DR) is one of the most common complications diabetes and has become a major global cause blindness. Curcumin, an extract Curcuma longa (turmeric), effective in preventing treating diabetes. Recent studies have shown that curcumin can delay DR development. However, there been no systematic review its treatment DR. This study will conduct meta-analysis currently published randomized controlled trials (RCT) for patients to evaluate efficacy safety. Methods We...
Nonalcoholic fatty liver disease (NAFLD) is highly correlated with obesity, and lifestyle changes to reduce weight remain the main therapeutic approach. The noncoding RNA miR‐22 has previously been reported be abundant in sera of NAFLD patients. In addition, directly targets peroxisome proliferative‐activated receptor, Pgc‐1α, proliferator‐activated receptor α, sirtuin 1 (Sirt1), which are important factors involved acid metabolism. Given that genes control metabolism we investigated whether...
Carbon and nitrogen metabolism are basic, but pivotal metabolic pathways in plants tightly coupled. Maintaining the balance of carbon is critical for plant survival. Comprehensively revealing carbon-nitrogen interactions important helpful understanding adaptation freshwater to CO2 limited aqueous environment. A comprehensive metabolomics analysis combined with physiological measurement was performed Ottelia alismoides acclimated high low CO2, respectively, a better how adjustment respond...
Feeding habits were the primary factor affecting gut bacterial communities in Ensifera. However, interaction mechanism between microbiota and feeding characteristics is not precisely understood. Here, of Ensifera with diverse was analyzed by shotgun metagenomic sequencing to further clarify composition function its relationship characteristics. Our results indicate that under influence habits, microbial showed specific Firstly, different differed significantly, among which diversity...
Abstract Deregulation of v-myc avian myelocytomatosis viral oncogene homolog (MYC) occurs in a broad range human cancers and often predicts poor prognosis resistance to therapy. However, directly targeting oncogenic MYC remains unsuccessful, indirectly inhibiting emerges as promising approach. Checkpoint kinase 1 (CHK1) is protein that coordinates the G2/M cell cycle checkpoint protects cancer cells from excessive replicative stress. Using c-MYC-mediated T-cell acute lymphoblastic leukemia...
To evaluate the prevalence of clinical mcr-1-positive Escherichia coli and Klebsiella pneumoniae characterize antimicrobial resistance profiles E. mcr-1-negative in China.A total 6264 (n = 3854) K. 2410) were collected from hospitalized patients 18 to 20 hospitals as part China Antimicrobial Resistance Surveillance Trial (CARST) between January 2007 June 2016. PCR was used screen for mcr-1 gene among all isolates. Antibiotic susceptibility testing performed using broth microdilution method....
We have shown previously, using confocal imaging and transport assays, that the N-terminus of sodium-dependent vitamin C transporter 2 (SVCT2) can redirect apical SVCT1 to basolateral membrane. Here, SVCT model was used further characterize targeting peptide signal. Both length (31 amino acids) sequence accuracy SVCT2 were found be important in activity, suggesting a structural requirement. However, N-terminal did not appear act alone, based on analyses heterologous chimeras. Although...
Elsinochrome (ESC), light-activated, nonhost-selective phytotoxin, is produced by many members of the genus Elsinoë and required for full virulence fungus.It appears that approaches disrupting ESC production will likely reduce disease severity caused pathogens.In this study, influence nutritional environmental factors on biosynthesis citrus scab pathogen E. fawcettii was investigated.Light critical initiation biosynthesis.E. highest amounts when grown potato dextrose agar (PDA) in light...
Abstract Citrus scab caused by Elsinoë fawcettii is cosmopolitan in humid citrus‐growing areas. We have previously demonstrated that production of non‐host selective elsinochrome phytotoxin a prerequisite for fungal full virulence and lesion formation. In this study we evaluated 71 field‐collected isolates from Florida pathogenicity toxin found most the to be pathogenic rough lemon, grapefruit sour orange able produce elsinochromes axenic culture. Elsinochromes were recovered, first time,...