A5079207845- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Cell Adhesion Molecules Research
- Workplace Health and Well-being
- Sleep and Work-Related Fatigue
- Monoclonal and Polyclonal Antibodies Research
- Gastrointestinal disorders and treatments
- Sleep and related disorders
- CNS Lymphoma Diagnosis and Treatment
- Digital Mental Health Interventions
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Spinal Dysraphism and Malformations
- Immunotherapy and Immune Responses
- Induction Heating and Inverter Technology
- Electric Motor Design and Analysis
- Telemedicine and Telehealth Implementation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemophilia Treatment and Research
- Nerve Injury and Rehabilitation
Mie University Hospital
2012-2025
Mie University
2015-2025
NEC (Japan)
1996-2012
Kinan Hospital
2011
Tokyo Institute of Technology
2002
National Cancer Research Institute
2002
Ajinomoto (United States)
1995
Nagoya Institute of Technology
1989
The prognostic value of negative regulators ferroptosis in patients with colorectal cancer (CRC) has not yet been fully elucidated. present study performed a systematic silico identification and selection candidate using Cancer Genome Atlas data cohort (n=367), followed by clinical validation through immunohistochemistry samples from CRC (n=166) further vitro evaluation. In analysis identified specific light-chain subunit the cystine/glutamate antiporter, AIFM2, NFE2L2, FTH1, GLS2,...
Abstract Purpose: We developed a complex of tumor antigen protein with novel nanoparticle delivery system cholesteryl pullulan (CHP). To target HER2 antigen, we prepared truncated 1-146 (146HER2) complexed CHP, the CHP-HER2 vaccine. designed clinical study to assess safety vaccine and HER2-specific T-cell immune responses measured by newly enzyme-linked immunospot assay mRNA-transduced phytohemagglutinin-stimulated CD4+ T cells in HLA-A2402-positive patients therapy-refractory...
Abstract Attenuation of the secondary injury spinal cord (SCI) can suppress spread tissue damage, possibly resulting in sparing that improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown G-CSF promotes recovery rodent models SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines evidence...
Integrins are the foremost family of cell adhesion molecules that regulate immune trafficking in health and diseases. Integrin alpha4 mediates organ-specific migration cells to inflamed brain, thereby playing critical role pathogenesis multiple sclerosis. Anti-alpha4 integrin therapy aiming block infiltration autoreactive lymphocytes brain has been validated several clinical trials for treatment This paper provides readers with an overview molecular structural bases activation as well...
Extracellular vesicles (EVs) in the plasma mediate important intercellular communications pathogenesis of cancer and inflammatory diseases. EVs express integrins that regulate target specificities programmed cell death ligand 1 2 (PD-L1 2) suppress lymphocyte activation. However, roles these molecules on systemic response syndrome (SIRS) sepsis remain little understood. This study aimed to investigate how EV expression PD-1 ligands might differ SIRS sepsis, compared with healthy controls,...
The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants.The APTT was examined patients suspected having disseminated intravascular coagulation (DIC) to analyze its diagnosis DIC or prediction outcome bleeding risk.DIC with fibrinogen < 2 g/L frequently associated infectious diseases (43.3%). heights first derivative peak (1stDP) second DP (2ndDP) were extremely low DIC, especially...
We have encountered five cases of intravascular large B‐cell lymphoma (IVL) presenting with central nervous system (CNS) mass lesions during their clinical course. The age the patients ranged from 50 to 74 years and three were male. All these histopathologically showed typical localization neoplastic cells in initial biopsy specimens obtained sites other than CNS. Despite multiagent chemotherapy, suffered single or multiple CNS 5–44 months after diagnosis IVL, except for one case which IVL...
The activated partial thromboplastin time (APTT) waveform includes several parameters that are related to various underlying diseases. APTT was examined in Regarding the pattern of waveform, a biphasic first or second derivative curve (DC) observed patients with hemophilia and positive for antiphospholipid (aPL) antibodies coagulation factor VIII (FVIII) inhibitors. DC fibrin formation at 1/2 height were prolonged hemophilia, inhibitors, aPL, treated anti-Xa agents, disseminated...
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by progressive fibrofatty replacement of the myocardium. In Japanese population, variants desmoglein-2 (DSG2) gene are a major cause ACM, typically following autosomal recessive inheritance pattern. Myosin-binding protein C (MYBPC3) primarily associated with hypertrophic (HCM). Here, we report severe pediatric case ACM compound heterozygous DSG2 and MYBPC3 variants. A 6-year-old asymptomatic girl was diagnosed...
The assessment of human epidermal growth factor receptor 2 ( HER 2) status is crucial for selecting patients with gastric cancer who may benefit from 2‐targeted therapy. Accurate using biopsy specimens important advanced‐stage cancer. Intratumoral heterogeneity 2, however, a major challenge in testing. Here, we aimed to examine whether could be accurately carried out currently used methods, namely, immunohistochemistry IHC ), FISH , and dual‐color situ hybridization DISH ). Human was...
2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) is the most abundant heterocyclic amine contained in cooked meat and fish. Although PhIP has been demonstrated to induce various types of tumors rats, lymphomas predominated mice using CDF1 strain. To investigate carcinogenic activity on other organs with a different genetic background, was administered C57BL/6N mice. After 40‐week administration 300 ppm high‐fat diet followed by continuous feeding high fat diet, developed adenomas...
In the present study we have established novel intermittent protocols featuring a high fat (HF) diet for efficient induction of large intestinal tumors with relatively small amount 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP). protocol 1, F344 male rats were first fed containing 400 p.p.m. PhIP 2 weeks, followed by continuous administration HF without 108 weeks. 2, week treatments repeated three times 4 intervals on alone, feeding 42 At termination experiments, 16 (3 19) and 45%...
Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a I/IIa trial, no adverse events were observed. conducted non-randomised, non-blinded, comparative which suggested the efficacy promoting recovery. Based on those results, are now performing III trial.The objective this study evaluate acute SCI....
A case of malignant phyllodes tumor the prostate in a 67‐year‐old man is reported. The patient was referred to hospital for urinary retention. From material taken at three transurethral resections (TURP), histological diagnosis benign prostatic hyperplasia made. However, fourth TURP, diagnosed due presence elongated epithelial ducts and proliferating cellular stroma with mitosis nuclear atypia. Two months later, total cystoprostatectomy performed. Histologically, composed dysplastic stromal...
Use of wearable sensor technology for studying human teamwork behavior is expected to generate a better understanding the interprofessional interactions between health care professionals.We used sociometric badges study how intensive unit (ICU) professionals interact and are socially connected.We studied face-to-face interaction data 76 healthcare in ICU at Mie University Hospital collected over 4 weeks via sensors.We detail spatiotemporal distributions staff members' inter-...
We evaluated the diagnostic criteria for disseminated intravascular coagulation (DIC), which was published by Japanese Society of Thrombosis and Hemostasis (JSTH), in 232 patients with suspected DIC without hematopoietic injury or infection. The diagnoses were as follows: (n = 116), pre-DIC 54), non-DIC 63). efficacy using a receiver operating characteristic analysis. area under curve odds ratio global test (GCT) scores diagnosis “DIC” high, whereas those “DIC pre-DIC” low, suggesting that...