A5037662951- Spinal Fractures and Fixation Techniques
- Photodynamic Therapy Research Studies
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Rheumatoid Arthritis Research and Therapies
- Hip disorders and treatments
- Bone and Joint Diseases
- Bone Tumor Diagnosis and Treatments
- Nanoplatforms for cancer theranostics
- Bone health and treatments
- Cervical and Thoracic Myelopathy
- Systemic Lupus Erythematosus Research
- Pelvic and Acetabular Injuries
- Intermetallics and Advanced Alloy Properties
- Management of metastatic bone disease
- Topic Modeling
- Porphyrin and Phthalocyanine Chemistry
- Orthopaedic implants and arthroplasty
- Natural Language Processing Techniques
- Biosimilars and Bioanalytical Methods
- Bone health and osteoporosis research
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Cancer, Hypoxia, and Metabolism
Niigata University Medical and Dental Hospital
2016-2025
Nishinomiya Municipal Central Hospital
2021-2025
Ohkawara Neurosurgical Hospital
2024
Toshiba (Japan)
2024
Osaka University
2014-2023
Sapporo Medical University Hospital
2004-2022
Hamamatsu University School of Medicine
2005-2021
Niigata University
2012-2021
Denso (United States)
2020-2021
Iwate University
2020
It has been hypothesized that suppression of bone remodeling allows microdamage to accumulate, leading increased fragility. This study evaluated the effects reduced turnover produced by bisphosphonates on accumulation and biomechanical properties cortical in dog rib. Thirty-six female beagles, 1-2 years old, were divided into three groups. The control group (CNT) was treated daily for 12 months with saline vehicle. remaining two groups risedronate (RIS) at a dose 0.5 mg/kg per day or...
Despite the importance of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) pathogenesis, mechanisms IFN-I production have not been fully elucidated. Recognition nucleic acids by DNA sensors induces and interferon-stimulated genes (ISGs), but involvement cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) stimulator (STING) SLE remains unclear. We studied role cGAS-STING pathway IFN-I-producing cascade driven serum.We collected sera from patients with (n=64), other...
The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role RA pathology by a comprehensive metagenome-wide association (MWAS).We conducted MWAS the Japanese population (ncase=82, ncontrol=42) using whole-genome shotgun sequencing high depth (average 13 Gb per sample). Our consisted three major bioinformatic analytic pipelines...
Cortical porosity in patients with hyperparathyroidism has raised the concern that intermittent parathyroid hormone (PTH) given to treat osteoporotic may weaken cortical bone by increasing its porosity. We hypothesized treatment of ovariectomized (OVX) cynomolgus monkeys for up 18 months recombinant human PTH(1-34) [hPTH(1-34)] LY333334 would significantly increase midshaft humerus but not have a significant effect on strength or stiffness humerus. also withdrawal PTH 6 after 12-month period...
Study Design. Cross-sectional regional bone mineral density of the pedicle was measured by peripheral quantitative computed tomography. Biomechanical tests were performed to clarify role in screw stability. Objectives. To identify structural characteristics that supports stability and differences these between normal osteoporotic vertebrae. Summary Background Data. The is an essential component many systems used align spine. contribution stability, however, has not been fully investigated....
Objective. SSc is an autoimmune disease characterized by fibrosis of the skin and internal organs. Although aetiology remains uncertain, many reports have suggested that IL-6 involved in pathogenesis. Tocilizumab, anti-IL-6 receptor antibody, anti-arthritis medicine works through blockade functions. To examine effect tocilizumab on SSc, we administered to two patients. Methods. Two dcSSc patients were at 8 mg/kg once a month for 6 months. One patient had pulmonary assessed CT spirometry,...
A retrospective multicenter study.To identify risk factors for postoperative complications associated with growing-rod (GR) surgery early-onset scoliosis (EOS).Results and of GR EOS have not been adequately studied.We evaluated clinical radiographical results from 88 patients who underwent in 12 spine centers Japan. The mean age at the time initial was 6.5 ± 2.2 years (range, 1.5-9.8 yr) follow-up period 3.9 2.6 2.0-12.0 yr). Risk were analyzed using binomial multiple logistic regression...
The purpose of this study was to evaluate the retention and discontinuation reasons seven biological disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting patients with rheumatoid arthritis (RA). 1,037 treatment courses bDMARDs from 2009 2016 [female, 81.8%; baseline age, 59.6 y; disease duration 7.8 factor positivity 81.5%; Disease Activity Score 28 joints using erythrocyte sedimentation rate (DAS28-ESR), 4.4; concomitant prednisolone 43.5% methotrexate 68.6%; Bio-naïve,...
Abstract Objectives: This study aims investigates real-world data on the demographics, prescribing practices, and healthcare costs of juvenile idiopathic arthritis (JIA) with polyarthritis or oligoarthritis compared to rheumatoid (RA) patients in adolescents young adults. Methods: Data from Japan Medical Center (JMDC) claims database for fiscal years (FY) 2016–2020 were analyzed. JIA RA defined as having at least 2 months disease-modifying antirheumatic drug (DMARD) prescriptions...
Intermittent administration of parathyroid hormone (PTH) has an anabolic effect in cancellous bone osteoporotic humans. However, the PTH on cortical with Haversian remodeling remains controversial. The aim this study was to determine effects biosynthetic human PTH(1-34) histology and mechanical properties rabbits, which exhibit remodeling. Mature New Zealand white rabbits were treated once daily injections vehicle, or PTH(1-34), LY333334, at 10 micrograms/kg/day 40 for 140 days. Body weight...
In Brief Study Design. Retrospective multi-institutional study Objective. To describe the surgical outcomes in patients with ossification of posterior longitudinal ligament thoracic spine (T-OPLL) and to clarify factors related outcomes. Summary Background Data. Detailed analyses T-OPLL have been difficult because rarity this disease. Methods. The subjects were 154 who surgically treated at 34 institutions between 1998 2002. procedures laminectomy 36, laminoplasty 51, anterior decompression...
<i>Background:</i> We have previously shown that fisetin, a flavonol, inhibits IL-4 and IL-13 synthesis by allergen- or anti-IgE-antibody-stimulated basophils. This time, we investigated the inhibition of production basophils other flavonoids attempted to determine fundamental structure related inhibition. additionally whether suppress leukotriene C4 T cells in response anti-CD3 antibody. <i>Methods:</i> Highly purified peripheral were stimulated for 12 h with...
Two water-soluble porphyrin self-assemblies consisting of bisacetylene- and monoacetylene-linked conjugated bis(imidazolylporphyrin) have been synthesized. Two-photon absorption (2PA) cross section values in water were determined as 7500 GM for 7900 bisporphyrin by femtosecond open-aperture Z-scan measurement. These almost the same those similar structure reported previously CHCl(3). Therefore, is suggested to be CHCl(3) aqueous solutions. Both compounds found efficiently generate singlet...
A 47-year-old female patient with Behçet's disease had been treated colchicine, prednisolone, cyclosporine A, and infliximab. Because she relapsed, however, treatment tocilizumab, a humanized anti-interleukin 6 receptor antibody, was started. This suppressed the patient's clinical manifestations, including ocular attacks, for 1 year improved her visual acuity. experience indicates that tocilizumab may constitute therapeutic option refractory disease.