A5088260569- Parkinson's Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Alcoholism and Thiamine Deficiency
- Neurological and metabolic disorders
- Trace Elements in Health
- RNA regulation and disease
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Autoimmune Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Research and Splicing
- Glycogen Storage Diseases and Myoclonus
- Neurogenetic and Muscular Disorders Research
- Barrier Structure and Function Studies
- Neurological Complications and Syndromes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Carbon and Quantum Dots Applications
Aichi Medical University
2013-2024
Mie University Hospital
2007-2024
Mie University
2018
Kobe University
2018
Chiba University
2018
Kyoto Prefectural University of Medicine
2018
National Center for Geriatrics and Gerontology
2018
Nara Medical University
2018
Nagoya University
2016-2017
Interleukin (IL)-25, a member of the IL-17 family cytokines, is expressed in brains normal mice. However, cellular source IL-25 and its function brain remain to be elucidated. Here, we show that plays an important role preventing infiltration inflammatory cells into central nervous system. Brain capillary endothelial (BCECs) express IL-25. it down-regulated by including tumor necrosis factor (TNF)-α, IL-17, interferon-γ, IL-1β, IL-6 vitro, also reduced active multiple sclerosis (MS) lesions...
Objective Progressive muscular atrophy (PMA) is a clinical diagnosis characterised by progressive lower motor neuron (LMN) symptoms/signs with sporadic adult onset. It unclear whether PMA simply phenotype of amyotrophic lateral sclerosis (ALS) in which upper (UMN) signs are undetectable. To elucidate the clinicopathological features patients clinically diagnosed PMA, we studied consecutive autopsied cases. Design Retrospective, observational. Setting Autopsied patients. Participants We...
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with eosinophilic bodies. The variable symptoms of NIID increase the difficulty in an antemortem diagnosis. shows leukoencephalopathy on brain magnetic resonance imaging MRI, but significance radiological findings have not been clarified.We examined autopsied case subcortical linear hyperintensities diffusion weighted (DWI) and fluid attenuation inversion recovery (FLAIR) imaging. Semiquantitative analysis...
The high incidence of amyotrophic lateral sclerosis ( ALS ) and parkinsonism‐dementia complex PDC has been previously known in the K ii P eninsula J apan G uam. Recently, accumulation various proteins, such as tau, trans‐activation response DNA binding protein 43 kDa (T DP ‐43), alpha‐synuclein (α S yn), was reported brains patients with / To confirm whether similar findings are present , we neuropathologically examined spinal cords 18 (clinical diagnoses: eight 10 H ohara V illage, which is...
A Japanese male patient presented with gait disturbance at the age of 69 years. His principal symptom was cerebellar ataxia for several He initially diagnosed as having olivopontocerebellar atrophy because dysarthria and gradually developed, head CT scan showed apparent cerebellum brainstem dilatation fourth ventricle. Later, he vertical gaze palsy, dysphagia, retrocollis, parkinsonism, axial dominant rigidity grasp reflex, therefore, diagnosis modified to progressive supranuclear palsy (...
Abstract Background Infantile neuroaxonal dystrophy (INAD) is a rare autosomal-recessive neurodegenerative disorder. Patients with INAD usually show neurological symptoms infant onset and die in childhood. Recently, it was reported that mutations the PLA2G6 gene cause INAD, but neuropathological analysis of genetically confirmed individuals has been limited. Results Here, we report Japanese individual associated compound heterozygous gene. A novel splice-site mutation resulting skipping...
Abstract The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, alpha‐synuclein‐immunoreactive inclusions. MSA patients who displayed abundant cytoplasmic inclusions (NCIs) the regions other than or have occasionally been diagnosed with variants of MSA. In this study, we report clinical pathologic findings characterized by prominent involvement hippocampus. We assessed 146 consecutively autopsied...
TAR DNA-binding protein of 43 kDa (TDP-43) plays a major role in the pathogenesis frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Although pathological continuity between FTLD ALS has been suggested, neuropathological changes lower motor neuron (LMN) systems have not assessed TDP-43-associated (FTLD-TDP), to our knowledge.To investigate FTLD-TDP by comparing their respective system.A retrospective clinical medical record review semiquantitative evaluation...
Argyrophilic grains are discrete punctate structures that bind to silver stains; they can be observed within the neuropil of limbic system, particularly in elderly. It has been reported argyrophilic more frequent patients with corticobasal degeneration (CBD) compared elderly population general. To determine frequency and significance CBD, we examined temporal lobes from 35 autopsy-proven CBD (mean age, 69.1 years) 28 grain disease 95.7 years). Grain distributions densities were evaluated...
Elderly human brains are vulnerable to multiple proteinopathies, although each protein has a different transmission pathway. Tau-immunoreactive astrocytes well-known in elderly brains. In contrast, astrocytic plaques, hallmark corticobasal degeneration (CBD), rarely occur aging and neurodegenerative disease other than CBD. To elucidate the clinicopathological correlation of aging-related pathology CBD, we examined 21 pathologically proven CBD cases our institute (12 males 9 females, with...
Pretangles are defined under the light microscope as diffuse and granular tau immunoreactivity in neurons tissue from patients with Alzheimer disease (AD) or corticobasal degeneration (CBD) considered to be a premature stage before neurofibrillary tangle formation. However, ultrastructure of pretangles remains described. To clarify similarities differences between AD CBD (AD-pretangles CBD-pretangles, respectively), we examined cortical each diseases. For direct electron microscopic (LM/EM)...
To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on Kii Peninsula (Kii ALS/PDC) by PET using [11C]PBB3 as ligand.This is a cross-sectional study 5 ALS/PDC and one asymptomatic participant dense family history from who took part this study. All were men, their age was 76 ± 8 (mean SD) years. Thirteen healthy men (69 6 years) participated controls (HCs). Dynamic scans performed following injection [11C]PBB3,...
A 78-year-old Japanese man presented with rapidly progressive dementia and gait disturbances. Eight months before the onset of clinical symptoms, diffusion-weighted magnetic resonance imaging (DWI) demonstrated hyperintensities in right temporal, parietal left medial occipital cortices. Two weeks after symptom onset, DWI showed extensive hyperintensity bilateral cerebral cortex, regions higher brightness that existed prior to still present. Four periodic sharp wave complexes were identified...
Recent pathological studies indicate that neuronal loss and/or TAR DNA-binding protein-43 kDa (TDP-43) inclusions are frequent in the striatum of patients with TDP-43-related frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS-TDP). However, no investigations have clarified impact such changes on striatal outputs these diseases. We analyzed efferent system 59 consecutively autopsied sporadic FTLD-TDP or ALS-TDP. The axon terminals neurons were...
We report an autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion (RT-QUIC) assay. A 61-year-old Japanese man presented acute onset consciousness disturbance, convulsions, but without past medical or family history progressive dementia, epilepsy, prion disease. Brain diffusion fluid-attenuated inverted recovery MR images revealed edematous cortical hyper-intensity, which diminished after phase....