A5003444525- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Mycobacterium research and diagnosis
- Eosinophilic Esophagitis
- Metabolism, Diabetes, and Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Rate Variability and Autonomic Control
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Eicosanoids and Hypertension Pharmacology
- Cancer Immunotherapy and Biomarkers
- Digestive system and related health
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
Sapporo Medical University
2019-2025
Sapporo Kosei General Hospital
2025
Kyoto Prefectural University of Medicine
2015-2024
Matsushita Memorial Hospital
2022-2024
Matsuyama Red Cross Hospital
2012-2024
Waseda University
2023
The Japanese Society of Gastroenterological Surgery
2022
Kyushu University
2017-2020
Kyushu University Hospital
2019
National Institute of Diabetes and Digestive and Kidney Diseases
2018
Linked color imaging (LCI) is a new image-enhanced endoscopy technique using laser light source to enhance slight differences in mucosal color. The aim of this study was compare the usefulness LCI and conventional white (WLI) for diagnosing Helicobacter pylori (H. pylori).We retrospectively analyzed images from 60 patients examined with WLI between October 2013 May 2014. Thirty had H. infections, other thirty tested negative after eradication therapy. Four endoscopists evaluated 2 types...
Background A new endoscope system with a laser light source, blue imaging ( BLI ), has been developed by F ujifilm that allows for narrow‐band observation. The aim of the present study was to evaluate utility diagnosis colorectal polyps. Methods We retrospectively analyzed 314 polyps were examined observation at K yoto P refectural U niversity M edicine between S eptember 2011 and J anuary 2013. surface vascular patterns detected published magnification: H iroshima classification used....
Proton pump inhibitors (PPIs) are widely used to treat gastro-esophageal reflux and prevent gastric ulcers, have been considered as low risk. However, recent studies identified possible associations between PPI use gut microbiota, suggesting that PPIs increases the risk of enteric infections, including Clostridium difficile infection. To investigate microbiota in Japanese users, we conducted 16S metagenomics analysis fecal samples collected from users healthy adults. In total, 36 non-users...
Natural killer (NK) cells exhibit strong cytotoxic activity against tumor without prior sensitization, and have the potential to exert antibody‐dependent cellular cytotoxicity (ADCC). In this clinical trial, we examined safety efficacy of use NK cells, generated using a novel expansion system, in combination with IgG1 antibodies for treatment advanced gastric or colorectal cancers. Treatment consisted trastuzumab‐ cetuximab‐based chemotherapy, plus adoptive cell therapy. For administration...
Irritable bowel syndrome (IBS) causes chronic abdominal pain and abnormal movements. The etiology involves complicated interactions among visceral hypersensitivity, disorders related to movements, stress. Changes in the microbiota affect IBS pathophysiology. We investigated changes colorectal motility, structure, response stress due maternal separation (MS) corticotropin-releasing hormone (CRH) administration rats.Neonatal rats were separated from their mothers for 3 h daily postnatal day...
Background and Aim With the aging of society, comorbidities or nutritional status are assessed prior to endoscopic submucosal dissection ( ESD ) for early gastric cancer EGC ). However, it is uncertain which factors important predicting prognosis in patients after . Thus, we aimed evaluate clinical outcomes , with respect status. Methods We carried out a retrospective study involving 708 585 who were enrolled between April 2007 March 2012. They classified into two groups; an elderly (≥80...
The human gut microbiota is involved in host health and disease development. Therefore, lifestyle-related diseases such as hypertension (HT), hyperlipidemia (HL), type 2 diabetes mellitus (T2D) may alter the composition of microbiota. Here, we investigated changes related to these their coexistence. This study 239 Japanese subjects, including healthy controls (HC). fecal was analyzed through isolation bacterial genomic DNA obtained from samples. Although there were no significant differences...
Functional dyspepsia (FD) is associated with poor health-related quality of life. Recent evidence suggests that the main pathogenesis suspect gut mucosa-associated microbiota (MAM). However, little known about MAM in FD subjects. The aim this study was to clarify relationship between upper gastrointestinal symptoms and characteristics MAM.Five mucosa samples from (intraoral, mid-esophagus, gastric body, antrum, descending portion duodenum) were collected a brush under endoscopic examination...
Abstract Background and Aims Free D-amino acids, which have different functions from L-amino recently been discovered in various tissues. However, studies on the potential interactions between intestinal inflammation acids are limited. We examined inhibitory effects of D-alanine pathogenesis inflammation. Methods investigated serum acid levels 40 patients with ulcerative colitis 34 healthy volunteers. For 7 days [d], acute was induced using dextran sulphate sodium C57BL/6J mice. Plasma were...
Abstract Background and Aim: Adequate mucosal elevation by submucosal injection is important for definitive en bloc resection prevention of perforation during endoscopic (EMR). The objective this study to determine the efficacy 0.13% hyaluronic acid (HA) solution high sustained colorectal EMR. Methods: was a prospective randomized controlled trial; total 196 patients with colon polyps < 20 mm diameter were enrolled in 1:1 ratio undergo EMR using either HA or normal saline (NS). primary...
Partially hydrolysed guar gum (PHGG), a water-soluble dietary fibre produced by the controlled partial enzymatic hydrolysis of beans, has various physiological roles. This study aimed to elucidate beneficial effects PHGG on colonic mucosal damage in murine 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Acute was induced male C57BL/6 mice with TNBS after 2 weeks pre-feeding (5 %). The inflammation evaluated using macroscopic scores, and neutrophil infiltration assessed...
Cold snare polypectomy (CSP) is commonly used for treating colorectal polyps <10 mm in diameter. We evaluated the analysis and safety of CSP larger polyps.We retrospectively analyzed 1006 resected with CSP. Indication was 2-14 that were diagnosed as benign neoplastic polyp by magnifying endoscopy. Various clinicopathological characteristics analyzed. Multivariate analyses to determine independent risk factors failure complete resection. With respect size, we compared therapeutic outcomes...
Mucosal healing and control of intestinal mucosal inflammation are important treatment goals for maintaining clinical remission in ulcerative colitis [UC] patients. Here, we investigated the efficacy linked colour imaging [LCI], a novel endoscopic enhancement system, diagnosing UC patients.All examinations were carried out with LASEREO system [FUJIFILM Co., Tokyo, Japan]. Fifty-two patients enrolled, 193 areas assessed by LCI examined. patterns classified as; A, no redness; B, redness...
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In pathophysiological study, VNS significantly restored autonomic balance, decreased mean pressure, attenuated vascular remodeling, and preserved right ventricular function. survival improved rate both prevention (VNS from 0 5 weeks after SU5416 injection) treatment 10 weeks) protocols. Thus, may serve as novel strategy for hypertension.
Background and study aim This aimed to assess the safety feasibility of endoscopic submucosal dissection (ESD) using a scissors‐type knife with prophylactic closure over‐the‐scope clip (OTSC) for superficial non‐ampullary duodenal epithelial tumors (SNADETs). Patients methods Consecutive patients who underwent ESD SNADETs >10 mm between January 2009 July 2019 were retrospectively enrolled. We performed either needle‐type (Flush Knife‐ESD) or (Clutch Cutter‐ESD). Mucosal defects...
AIMTo assess the safety and feasibility of laparoscopic endoscopic co-operative surgery (LECS) for early nonampullary duodenal tumors. METHODSTwelve patients with a non-ampullary tumor underwent LECS at our hospital.One patient had two mucosal lesions in duodenum.The indication this procedure was presence tumors low risk lymph node metastasis.In particular, included small (less than 10 mm) submucosal (SMT) epithelial tumors, such as cancers or large adenomas malignant suspicion.The...