A5046070131- Gut microbiota and health
- Diet and metabolism studies
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Food composition and properties
- Cancer, Hypoxia, and Metabolism
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Prostate Cancer Treatment and Research
- Thermal Regulation in Medicine
- Digestive system and related health
- Diet, Metabolism, and Disease
- Muscle Physiology and Disorders
- Viral gastroenteritis research and epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Sexual Differentiation and Disorders
- Advanced Glycation End Products research
Ishikawa Prefectural University
2016-2025
Kyoto Prefectural University of Medicine
2012-2021
National Institute Of Technology, Ishikawa College
2020
National Institute of Diabetes and Digestive and Kidney Diseases
2018
ProQuest (United States)
2018
Osaka Prefecture University
2007-2011
Gut microbiota have profound effects on bile acid metabolism by promoting deconjugation, dehydrogenation, and dehydroxylation of primary acids in the distal small intestine colon. High-fat diet-induced dysbiosis gut dysregulation may be involved pathology steatosis patients with non-alcoholic fatty liver disease. Epigallocatechin-3-gallate (EGCG), most abundant polyphenolic catechin green tea, has been widely investigated for its inhibitory or preventive against liver. The aim present study...
High-fat diet (HFD)-induced alteration in the gut microbial composition, known as dysbiosis, is increasingly recognized a major risk factor for various diseases, including colon cancer. This report describes comprehensive investigation of effect agaro-oligosaccharides (AGO) on HFD-induced alterations short-chain fatty acid contents and bile metabolism mice. C57BL/6N mice were fed control or HFD, with without AGO. Terminal restriction fragment-length polymorphism (T-RFLP) analysis produced...
Androgen receptor (AR) functions as a transcriptional factor for genes involved in proliferation and differentiation of normal cancerous prostate cells. Coactivators that bind to AR are required maximal androgen action. Here we report increasing the expression glyceraldehyde-3-phosphate dehydrogenase (GAPDH) cancer cell line by little 1.8-fold enhances activity (but not glucocorticoid or estrogen alpha) ligand-dependent manner results an increased prostate-specific antigen. Small...
Irritable bowel syndrome (IBS) causes chronic abdominal pain and abnormal movements. The etiology involves complicated interactions among visceral hypersensitivity, disorders related to movements, stress. Changes in the microbiota affect IBS pathophysiology. We investigated changes colorectal motility, structure, response stress due maternal separation (MS) corticotropin-releasing hormone (CRH) administration rats.Neonatal rats were separated from their mothers for 3 h daily postnatal day...
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that pathogenesis of loss may involve dysbiosis gut microbiota accompanying chronic inflammation or altered metabolism. In this study, we evaluated possible effects modifying microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related its mechanism using colon-26...
Abstract Background and Aims Free D-amino acids, which have different functions from L-amino recently been discovered in various tissues. However, studies on the potential interactions between intestinal inflammation acids are limited. We examined inhibitory effects of D-alanine pathogenesis inflammation. Methods investigated serum acid levels 40 patients with ulcerative colitis 34 healthy volunteers. For 7 days [d], acute was induced using dextran sulphate sodium C57BL/6J mice. Plasma were...
BTB and CNC homolog 1 (Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1), which plays an important role in the protection cells tissues against acute chronic inflammation. However, Bach1 gastrointestinal mucosal defense system remains little understood. HO-1 supports suppression experimental colitis localizes mainly macrophages colonic mucosa. This study was undertaken to elucidate Bach1/HO-1 system's effects on pathogenesis colitis. used C57BL/6 (wild-type) homozygous...
Partially hydrolysed guar gum (PHGG), a water-soluble dietary fibre produced by the controlled partial enzymatic hydrolysis of beans, has various physiological roles. This study aimed to elucidate beneficial effects PHGG on colonic mucosal damage in murine 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Acute was induced male C57BL/6 mice with TNBS after 2 weeks pre-feeding (5 %). The inflammation evaluated using macroscopic scores, and neutrophil infiltration assessed...
Abstract Background and Aims Patients with inflammatory bowel disease [IBD], especially Crohn’s disease, often develop zinc deficiency. However, the precise mechanisms by which deficiency affects IBD pathology, particularly intestinal macrophage function, remain unclear. We studied effects of on development progression colitis in mice. Methods To induce colitis, mice were treated 2,4,6-trinitrobenzene sulphonic acid. Rag1−/− then given injections naïve CD4+CD62L+ T cells. The respective...
The petals of flowering plants should retain unique antioxidants that have not been found in the fruits, as need to stay open attract pollinators against photooxidation and devise a solution avoid eating attacks. We reported yellow freesia cultivars (Freesia x hybrida) accumulated original apocarotenoids, mono- di-neapolitanosyl crocetin. Here, petals, we discovered eight novel flavonoids by their structural determination, including four 3′-caffeoylquercetin 3,7-glycosides, one 3-glycoside,...
<title>Abstract</title> Water-soluble cellulose acetate (WSCA), derived from natural and acetate, can be used as a food additive deliver to the large intestine. In this study, we investigated effects of dietary WSCA supplementation on impaired glucose metabolism in db/db mice, model type 2 diabetes mellitus. db/m mice were fed either control diet or WSCA-supplemented for eight weeks. The group exhibited improved intolerance lipid without any loss skeletal muscle mass grip strength....
Abstract The amyloid β (Aβ) aggregation inhibitory activity of compounds isolated from eelgrass (Zostera marina) was evaluated, and it found that in the flavonoid compounds, when hydroxy substituent replaced by methoxy or sulfate, weakened order. efficacy rosmarinic acid treatment against mutant nematodes also evaluated.
Acetyl salicylic acid (ASA) is one of the most frequently prescribed medications for secondary prevention cardiovascular and cerebrovascular events. It has recently been reported to cause small intestinal mucosal injury at a considerably higher rate than previously believed. The aim this study investigate mechanism by which occurs using an in vitro intestine model focusing on role oxidative stress cell permeability. Differentiated Caco-2 exhibits phenotype similar human epithelium. We...