A5048928107- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Metastasis and carcinoma case studies
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Retinal and Optic Conditions
- 3D Shape Modeling and Analysis
- Testicular diseases and treatments
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Genital Health and Disease
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Neutropenia and Cancer Infections
- Intraocular Surgery and Lenses
- Autoimmune Bullous Skin Diseases
- Muscle and Compartmental Disorders
University of Tsukuba
2011-2025
Nippon Medical School Hospital
2017-2024
Nippon Medical School
2010-2024
Tohoku University Hospital
2024
Kyoto Prefectural University of Medicine
2019-2023
Gunma University
2022
Keio University
2019-2021
Tama Art University
2020
Yamaguchi Red Cross Hospital
2013
Seiwa Hospital
2010
three isoenzymes which belong to family A have molecular weights of approximately 63,000.The other two isoenzymes, B, 59,000.The enzymes both families appear be single polypeptide chains.That the contain asparagine-' Addition NaCl buffer stabilizes amylases during gel -_____ fiitration procedure.
Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that pathogenesis of loss may involve dysbiosis gut microbiota accompanying chronic inflammation or altered metabolism. In this study, we evaluated possible effects modifying microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related its mechanism using colon-26...
This study presents the enfortumab vedotin (EV) treatment analysis at our institution. We retrospectively analyzed patients with metastatic urothelial cancer (mUC) treated EV between January 2021 and October 2023. was administered 1.25 mg/kg on days 1, 8, 15 in a 28-day cycle. Whole-body computed tomography scans were performed to assess response. Patient characteristics, histories, response rates, progression-free survival, adverse events evaluated. Response rates determined, recorded....
Background. In haemodialysis (HD) patients, abdominal visceral fat is accumulated while lean body mass decreased irrespective of their indexes (BMI). However, it poorly understood which changes and muscle masses are more associated with arteriosclerosis. We aimed at examining the associations thigh markers arteriosclerosis in chronic HD patients a cross-sectional fashion. Patients Methods. measured area (AVFA), subcutaneous (ASFA), (TMA) TMA standardized for femoral shaft (TMA/FSA) by...
Abstract Background Enfortumab vedotin (EV) was approved for patients with metastatic urothelial carcinoma (mUC) who progressed after anticancer therapy on September 2021 in Japan. The association between the occurrence of EV-related side effects and clinical outcome remains to be elucidated. Methods We identified 97 mUC treated EV at our five institutions from date approval March 2023. median follow-up period 7.0 months. retrospectively analyzed efficacy safety EV. Results age 71 years old,...
Deep learning algorithms have achieved great success in cancer image classification. However, it is imperative to understand the differences between deep and human approaches. Using an explainable model, we aimed compare learning-focused regions of magnetic resonance (MR) images with cancerous locations identified by radiologists pathologists. First, 307 prostate MR were classified using a well-established neural network without locational information cancers. Subsequently, assessed whether...
Background: Vacuolar ATPase (V-ATPase) is involved in cancer development. The use of proton pump inhibitors (PPIs) as V-ATPase has been reported to enhance the effectiveness chemotherapy certain cancers. This study aimed evaluate effect PPIs on for esophageal cancer. Methods: To investigate effects cells, human KYSE50 and 70 cells were plated 3 (lansoprazole, esomeprazole, vonoprazan) added at various concentrations with 5-Fluorouracil (5-FU) corresponding a cell viability assay. PPI...
Abstract Accurate prostate cancer screening is imperative for reducing the risk of death. Ultrasound imaging, although easy, tends to have low resolution and high inter-observer variability. Here, we show that our integrated machine learning approach enabled detection pathological high-grade by ultrasound procedure. Our study included 772 consecutive patients 2899 images obtained at Nippon Medical School Hospital. We applied analyses using imaging data clinical detect cancer. The area under...
Abstract Background Prolonged laparoscopic nephroureterectomy (LNU) for upper tract urothelial cancer (UTUC) can increase the frequency of intravesical recurrence after surgery. Therefore, it is important urological surgeons to have knowledge on preoperative risk factors prolonged LNU. However, few studies investigated We hypothesized that quantity perirenal fat affects pneumoretroperitoneum time (PRT) retroperitoneal LNU (rLNU). This study aimed investigate PRT during rLNU. Methods reviewed...
Several effective treatment modalities against metastatic castration-resistant prostate cancer (mCRPC) are available; however, an unmet clinical need persists for mCRPC because resistance to these therapies is inevitable. This study aimed evaluate the status of comprehensive genomic profiling (CGP) and its impact on subsequent treatments patients with at our hospital.
The optimal treatment modality for locally advanced prostate cancer has not been established. Radiotherapy, hormonal therapy, and combination treatments are the main strategies, although feasibility of radical prostatectomy as a first-line therapy needs to be considered. This retrospective analysis pathological results extracted specimens evaluated long-term oncological outcomes high-risk treated surgically. association number risk factors with outcome was specifically analyzed.We identified...
High body mass index (BMI) and visceral obesity were reported to be associated with prolonged transperitoneal laparoscopic radical nephrectomy (LRN); however, factors that prolong retroperitoneal LRN remain unknown. We therefore investigated performed by non-expert surgeons.We defined non-experts surgeons as not certified perform surgery the Japanese Society of Endourology. retrospectively reviewed medical records 59 consecutive patients renal cell carcinoma treated at our hospital between...
Robot-assisted laparoscopic prostatectomy (RALP) for prostate cancer was introduced in 2000 and rapidly gained popularity. The Da Vinci Surgical System? can ensure improved local control of fewer perioperative complications. However, RALP is performed the steep-Trendelenburg position (a combination lithotomy head-down tilt position/Lloyd-Davies position) to obtain a good surgical view, as result, well leg compartment syndrome (WLCS) become serious complication RALP. Here, we report case WLCS...
Various devices for isolating and detecting circulating tumor cells (CTCs) have been developed, whereas the CellSearch® system has clinically used in numerous prostate CTC studies. CTCs might become more useful surrogate markers of cancer, they should be measured all settings, but a smaller, low-cost capture is required.An inexpensive highly sensitive microfluidic CTC-capture polymeric chip, developed by Toyama Industrial Technology Center, as described following text, was to assess number...
<b><i>Purpose:</i></b> Bladder endometriosis (BE) is rare. Deep invasive difficult to control with medications alone; such cases need surgical treatment. Good results of laparoscopic partial cystectomy a transurethral (TU) resectoscope by the see-through technique for patients BE are reported. <b><i>Materials and Methods:</i></b> From January 2008 February 2016, 12 symptomatic were seen in our institution. The chief complaints 9 micturition...
A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis a large pelvic mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate palpable digital rectal examination. tumor suspected, transrectal biopsy transurethral ureteral stent placement performed. Histological immunohistochemical studies revealed diffuse B-cell lymphoma. Positron emission tomography-computed showed...