A5044657759- Analytical Chemistry and Sensors
- Growth Hormone and Insulin-like Growth Factors
- Electrochemical sensors and biosensors
- Pituitary Gland Disorders and Treatments
- Electrochemical Analysis and Applications
- Cardiovascular Function and Risk Factors
- Electron Spin Resonance Studies
- Helicobacter pylori-related gastroenterology studies
- Connective tissue disorders research
- Conducting polymers and applications
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 diagnosis using AI
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Virology and Viral Diseases
- Ovarian function and disorders
- Asthma and respiratory diseases
- Uterine Myomas and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- ECG Monitoring and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Issues in Pregnancy
The University of Tokyo
1994-2025
The University of Kitakyushu
2022-2025
Nippon Medical School
2025
University of Tokyo Hospital
2021-2024
Tokushima Red Cross Hospital
2024
Fujieda Municipal General Hospital
2021-2024
Jikei University School of Medicine
2020-2024
Tokyo Metropolitan Komagome Hospital
2023-2024
National Center For Child Health and Development
2022-2023
Fujisawa City Hospital
2023
Vascular endothelial growth factor (VEGF or vascular permeability factor), a direct-acting, cell-specific mitogen, has been suggested to be involved in development and maintenance of vasculatures tumor neovascularization normal tissues. To investigate possible roles VEGF ischemic hearts, we studied induction mRNA by ischemia hypoxia using coronary artery-ligated hearts vivo perfused cultured myocardial cells vitro. was potently induced the heart vivo. In maximum expression rapidly (within 30...
Epidemiological studies demonstrated that cleaning work and frequent use of products are risk factors for asthma. Laundry detergents have been reported to epithelial barrier-opening effects. However, whether laundry directly induce airway inflammation its mechanisms in vivo remain be elucidated.Two commercial two commonly used surfactants cosmetics (sodium lauryl sulfate sodium dodecyl benzene sulfonate) were intranasally administered mice. Lungs analyzed using flow cytometry, histology,...
Pembrolizumab is an immune checkpoint inhibitor (ICI) of programmed cell death-1 category, used for treating various types cancer. ICIs can sometimes result in immune-related adverse events. Allergic bronchopulmonary mycosis (ABPM) induced by ICI has rarely been reported. We hereby report the case 83-year-old woman who experienced non-Aspergillus ABPM with eosinophilia pembrolizumab that had prescribed bladder Steroid monotherapy prednisone was successful and could be resumed. Through...
Abstract Background In recent years, there has been considerable research on the use of artificial intelligence to estimate age and disease status from medical images. However, estimation chest X-ray (CXR) images not well studied clinical significance estimated fully determined. Methods To address this, we trained a deep neural network (DNN) model using more than 100,000 CXRs patients’ solely CXRs. We applied our DNN 1562 consecutive hospitalized heart failure patients, 3586 patients...
BACKGROUND: Marfan syndrome (MFS) is an inherited disorder caused by mutations in the FBN1 gene encoding fibrillin-1, a matrix component of extracellular microfibrils. The main cause morbidity and mortality MFS thoracic aortic aneurysm dissection, but underlying mechanisms remain undetermined. METHODS: To elucidate role endothelial XOR (xanthine oxidoreductase)–derived reactive oxygen species progression, we inhibited vivo function either cell (EC)–specific disruption Xdh or systemic...
Because the early diagnosis of subclinical cardiac sarcoidosis (CS) remains difficult, we developed a deep learning algorithm to distinguish CS patients from healthy subjects using echocardiographic movies.
Left ventricular dilatation (LVD) and left hypertrophy (LVH) are risk factors for heart failure, their detection improves failure screening. This study aimed to investigate the ability of deep learning detect LVD LVH from a 12-lead electrocardiogram (ECG). Using ECG echocardiographic data, we developed machine models LVH. We also examined conventional criteria diagnosis calculated area under receiver operating characteristic (AUROC) curve, sensitivity, specificity, accuracy each model...
To clarify the molecular mechanism underlying lysophosphatidylcholine (LPC) signaling, we studied effect of LPC on intracellular free calcium concentration ([Ca2+]i) in murine peritoneal macrophages. when added alone induced biphasic elevation [Ca2+]i, which consisted a rapid increase followed by sustained elevation. LPC, with equimolar cholesterol, only was blocked WEB-2086, selective platelet-activating factor (PAF) receptor antagonist. These results suggest exerts specific Ca2+ signaling....
Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS), and insulin-sensitizing drugs are used to induce ovulation. Recently, it was reported that an extract from Maitake mushroom (Grifola frondosa) improves insulin resistance.The objective explore the effects (SX-fraction: MSX) ovulation in patients with PCOS comparison combination clomiphene citrate (CC).We conducted open trial 80 at three clinics Japan. Seventy-two (72) new were randomly assigned receive MSX or CC...
Deep learning models can be applied to electrocardiograms (ECGs) detect left ventricular (LV) dysfunction. We hypothesized that applying a deep model may improve the diagnostic accuracy of cardiologists in predicting LV dysfunction from ECGs. acquired 37,103 paired ECG and echocardiography data records patients who underwent between January 2015 December 2019. trained convolutional neural network identify with (ejection fraction < 40%) using dataset 23,801 When tested on an independent set...
We retrospectively determined the safety and efficacy of endoscopic delivery (ED) capsule endoscopes.We enrolled 10,156 patients who underwent small bowel endoscopy (SBCE), 3182 patency (PC), 1367 colon (CCE), at 11 gastroenterological nine pediatric centers.Small endoscopies, PCs, CCEs were endoscopically delivered to 546 (5.4%), 214 (6.7%), 14 (1.0%) patients, respectively. Only mild complications occurred for 21.6% (167/774), including uneventful mucosal damage, bleeding, abdominal pain....
Phagocytic cells, such as neutrophils and monocytes, consume oxygen generate reactive species (ROS) in response to external stimuli. Among the various ROS, superoxide anion radical is known be primarily produced by nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase. In current study, we attempt evaluate respiratory burst monitoring rapid consumption of using scanning electrochemical microscopy (SECM) imaging. The was measured a human monocytic cell line (THP-1 cells)...
Objectives: We aimed to evaluate the surgical results for ectopic pregnancy (EP) treated at Fukushima Red Cross Hospital over a 20-year period from 2002 2021. Materials and Methods: evaluated incidence, procedures, site of implantation, amount hemoperitoneum, proportion cases with risk factors EP. Results: Two hundred fifty-nine EP were surgically. The incidence seemed be gradually decreasing in recent years. By site, 235 (90.7%) EPs tubal pregnancies (TPs), 13 interstitial (IPs), 7 ovarian...
An antithrombogenic electrochemical superoxide anion radical (O2•−) sensor was developed based on the concept of biomimetics. The fabricated by modification a carbon microelectrode surface with polymerized iron 5,10,15,20-tetra(3-thienyl)porphyrin (FePor), followed coating polyethylenedioxythiophene (PEDOT)/heparin or PEDOT/carboxymethyl dextran sulfate (CMDS) layer. sensors exhibited an amperometric oxidation current for O2•−, even after immersion in bovine blood 2 weeks, while without...
Abstract Trichobezoars (hair bezoars) are primarily observed in adolescent girls who pull their hair followed by its ingestion. Endoscopic removal of trichobezoars is challenging, and these masses often require surgical removal. Recently, although it has been reported that Coca‐Cola could effectively dissolve persimmon phytobezoars, was ineffective dissolving trichobezoars. We report a case which directly injected into trichobezoar successful endoscopic the mass. A 9‐year‐old girl visited...
We have developed an electrochemical reactive oxygen/nitrogen species sensor that can detect superoxide anion radicals (O2-•) and nitric oxide (NO). The was fabricated by surface modification of electrode with polymerized iron tetrakis(3-thienyl)porphyrin (FeT3ThP), it either O2-• or NO switching the applied potential. Furthermore, we a improved selectivity coating Nafion® film onto poly(FeT3ThP)-modified electrode. An interference current caused NO2- seen for electrode, while significantly...
Abstract Prostaglandin E-major urinary metabolite (PGE-MUM) is a biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic (HR) pediatric UC (6–16 years) comparison with fecal calprotectin (FCP). ER HR were defined as Mayo score (MES) 0 Matts’ histological grades (Matts) 1 or 2, respectively. A total 104 39...
The growth and development of plants is deleteriously affected by various biotic abiotic stress factors. Wounding in caused exposure to environmental stress, mechanical via herbivory. Typically, oxidative burst response wounding associated with the formation reactive oxygen species, such as superoxide anion radical (O2•-), hydrogen peroxide (H2O2) singlet oxygen; however, few experimental studies have provided direct evidence their detection plants. Detection O2•- plant tissues been...
A 73-year-old man presented with right lower back pain and dysuria. Right hydronephrosis a large pelvic mass were seen on computed tomography (CT). Although his prostate-specific antigen (PSA) was 0.5 ng/mL, an irregularly enlarged, stony, hard prostate palpable digital rectal examination. tumor suspected, transrectal biopsy transurethral ureteral stent placement performed. Histological immunohistochemical studies revealed diffuse B-cell lymphoma. Positron emission tomography-computed showed...