A5103188472- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fuel Cells and Related Materials
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Coronary Artery Anomalies
- CRISPR and Genetic Engineering
- Infective Endocarditis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Cardiac and Coronary Surgery Techniques
- Nutrition and Health in Aging
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Diaphragmatic Hernia Studies
University of Tokyo Hospital
2011-2025
The University of Tokyo
2015-2025
Nagoya University
2003-2025
Nagoya University Hospital
2022-2024
Columbia University Irving Medical Center
2017-2020
National Cerebral and Cardiovascular Center
2011-2019
Columbia University
2018
NewYork–Presbyterian Hospital
2018
Toyo University
2015
Kyoto University
2009
We recently developed a novel minimally invasive surgical approach that combines extracorporeal membrane oxygenation and CentriMag ventricular assist device (Ec-VAD) for the treatment of cardiogenic shock as short-term circulatory support. compared outcomes this new to conventional biventricular (BiVAD) support through median sternotomy. Between July 2015 August 2016, 22 patients were implanted with Ec-VAD 90 BiVAD. The circuit was configured left apical cannulation via mini-thoracotomy...
Abstract Background Identifying patients on dialysis among those with an estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m 2 remains challenging. To facilitate clinical research in advanced chronic kidney disease (CKD) using electronic health records, we aimed to develop algorithms identify laboratory data obtained routine practice. Methods We collected of eGFR from six core hospitals across Japan: four for the derivation cohort and two validation cohort. The candidate...
BACKGROUND: Marfan syndrome (MFS) is an inherited disorder caused by mutations in the FBN1 gene encoding fibrillin-1, a matrix component of extracellular microfibrils. The main cause morbidity and mortality MFS thoracic aortic aneurysm dissection, but underlying mechanisms remain undetermined. METHODS: To elucidate role endothelial XOR (xanthine oxidoreductase)–derived reactive oxygen species progression, we inhibited vivo function either cell (EC)–specific disruption Xdh or systemic...
Continuous-flow left ventricular assist devices (LVADs) have greatly improved the prognosis of patients with end-stage heart failure, even if continuous flow is different from physiological in that it has less pulsatility. A novel pump controller continuous-flow LVADs been developed, which can change its rotational speed (RS) synchronization native cardiac cycle, and we speculated pulsatile mode, increases RS just systolic phase, create more pulsatility than current system constant does. The...
Background: When left ventricular assist device (LVAD) therapy no longer is able to achieve patients' desired quality of life, withdrawal LVAD (WLVAD) may be requested. Objectives: To evaluate factors associated with WLVAD, including the time taken before WLVAD. Setting/Subjects: Sixty-two patients who newly underwent initial during January 1, 2010 and October 30, 2018 subsequently WLVAD by December 31, were divided into those participated in decision (defined as PT+, n = 14), could not...
BACKGROUND: Genetic variation of CYP2A6 is shown to alter nicotine metabolism. This study was developed investigate the genetic influence whole deletion-allele on active and passive smoking behavior. METHODS: Two hundred forty Japanese adults, who visited Aichi Cancer Center as outpatients, were genotyped for wild-type (CYP2A6∗ 1A, CYP2A6∗ 1B) deletion-type (CYP2A6∗4C) polymorphism CYP2A6. Information about status obtained by a self-administered questionnaire. behavior evaluated using Mantel...
BackgroundThe use of percutaneous mechanical circulatory support (MCS) in the treatment cardiogenic shock has increased. However, limitations flow capability, ventricular unloading effect, durability, and mobility remain. We reviewed our single-center experience with continuous-flow external assist devices (VADs) to determine role temporary VADs for contemporary MCS era.MethodsWe retrospectively 252 patients who underwent VAD insertion between January 2007 December 2016. To investigate...
Continuous-flow left ventricular assist devices (CF-LVADs) are widely used to treat patients with end-stage heart failure. Although continuous flow is different from physiological flow, show improved outcomes after CF-LVAD implantation. A novel rotational speed (RS) modulation system (EVAHEART) has been developed, which can change RS in synchronization the native cardiac cycle. We conducted present study investigate influence of on pulsatility peripheral perfusion.We implanted EVAHEART at...
Desminopathy is a cardiac and skeletal myopathy caused by disease-causing variants in the desmin (DES) gene represents subgroup of myofibrillar myopathies, where cytoplasmic desmin-postive immunoreactivity pathological hallmark. We herein report 28-year-old Japanese man who was initially diagnosed with sporadic hypertrophic cardiomyopathy atrioventricular block at 9 years old developed weakness soft palate extremities. The myocardial tissue dissected during implantation ventricular-assisted...
A novel control system for the EVAHEART left ventricular assist device (LVAD), known as Native Heart Load Control System (NHLCS), can change device's rotational speed (RS) in synchrony with heartbeat. The enhanced coronary flow (CoF) counter-pulse mode normal goats' hearts, so we examined CoF goats acute ischemic heart failure (HF).We studied 14 (56.1±6.9kg) HF induced by microsphere embolization. We installed and ran 4 modes [continuous support, circuit-clamp, (raise RS diastole), co-pulse...
ObjectiveWe previously developed a native heart load control system for continuous-flow left ventricular assist device and demonstrated that the rotational speed synchronized with cardiac cycle can alter preload myocardial oxygen consumption. In present study, we assessed this in conscious goat model of chronic failure.MethodsChronic failure was induced by coronary microsphere embolization ascending artery subsequent rapid pacing 6 goats. After 4 to weeks pacing, goats showed decreased...
Abstract We have developed a rotational speed ( RS ) modulation system for continuous‐flow left ventricular assist device EVAHEART that can change in synchronization with patient's electrocardiogram. Although is considered not to cause significant acquired von Willebrand syndrome, there remains concern the repeated acceleration and deceleration of impeller may degrade factor vWF multimers. Accordingly, we evaluated influence our on dynamics. A simple mock circulation was used. The filled...