A5025981434- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular and exercise physiology
- Cardiovascular Issues in Pregnancy
- Intensive Care Unit Cognitive Disorders
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Heart rate and cardiovascular health
- Protease and Inhibitor Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Memory and Neural Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
Kyushu University Hospital
2017-2025
Kyushu University
2004-2023
Amyloidosis Foundation
2021
Research Network (United States)
2021
Weatherford College
2021
Tokyo University of Science
2012
Shanghai Sixth People's Hospital
2007
Shanghai Jiao Tong University
2007
Osaka University
2006
The University of Tokyo
2006
Background:With aging population, the prevalence and incidence of heart failure (HF) have been increasing worldwide. However, characteristics outcomes patients with HF in an era are not well established Japan.
Abstract Aims Individual risk stratification is a fundamental strategy in managing patients with heart failure (HF). Artificial intelligence, particularly machine learning (ML), can develop superior models for predicting the prognosis of HF patients, and administrative claim data (ACD) are suitable ML analysis because ACD structured database. The objective this study was to analyse using an algorithm, predict 1 year mortality HF, finally easy‐to‐use prediction model high accuracy top...
Abstract Background Identifying patients on dialysis among those with an estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m 2 remains challenging. To facilitate clinical research in advanced chronic kidney disease (CKD) using electronic health records, we aimed to develop algorithms identify laboratory data obtained routine practice. Methods We collected of eGFR from six core hospitals across Japan: four for the derivation cohort and two validation cohort. The candidate...
Objective— We have previously shown that the intramuscular transfer of anti–monocyte chemoattractant protein-1 (MCP-1) gene (called 7ND) is able to prevent experimental restenosis. The aim this study was determine in vivo efficacy and safety local delivery 7ND via gene-eluting stent reducing in-stent neointima formation rabbits cynomolgus monkeys. Methods Results— here found vitro, effectively inhibited chemotaxis mononuclear leukocytes also proliferation/migration vascular smooth muscle...
Aim: The use of currently marketed drug-eluting stents (DES) presents safety concerns, including an increased risk for late thrombosis in the range 0.6% per year patients, acute coronary syndrome, which is thought to result from delayed endothelial healing effects. A new DES system targeting vascular smooth muscle cells without adverse effects on therefore needed. Platelet-derived growth factor (PDGF) plays a central role pathogenesis restenosis; therefore, we hypothesized that imatinib...
The contemporary outcome of balloon pulmonary angioplasty (BPA) and endarterectomy (PEA) in patients with chronic thromboembolic hypertension (CTEPH) are unclear.
Nuclear factor-kappaB (NF-kappaB) plays a critical role in the vascular response to injury. However, of NF-kappaB mechanism in-stent restenosis remains unclear. We therefore tested hypothesis that blockade by stent-based delivery cis-element "decoy" reduces neointimal formation.Stents were coated with polymer containing or not decoy, which represented fast-release formulation (<7 days). Bare, polymer-coated, and decoy-eluting stents implanted iliac arteries hypercholesterolemic rabbits....
Background Withdrawal of optimal medical therapy has been reported to relapse cardiac dysfunction in patients with dilated cardiomyopathy (DCM) whose function had improved. However, it is unknown whether beta‐blockers can prevent deterioration those patients. We examined the effect on left ventricular ejection fraction (LVEF) recovered DCM. Methods and Results analyzed clinical personal record DCM, a national database Japanese Ministry Health, Labor Welfare, between 2003 2014. Recovered DCM...
The precise mechanism by which angiotensin II type 1 receptor blocker reduces in-stent restenosis in clinical trials is unclear. We, therefore, investigated the of neointima formation. Male cynomolgus monkeys and rabbits were fed a high-cholesterol diet allocated to untreated control groups. Five days after grouping, multilink stents implanted iliac artery. reduced development formation approximately 30% monkeys. To investigate potential mechanisms, we examined expression renin-angiotensin...
Abstract Purpose Remimazolam, a newly developed ultra-short-acting benzodiazepine, provides early recovery of consciousness but its effects on memory are unclear. This study examined after emergence from general anesthesia using remimazolam. Methods Seventy-four patients undergoing breast surgery between October 2021 and March 2022 were enrolled randomly assigned to receive propofol (control group) or remimazolam as anesthetic during surgery. The primary endpoint was the number posters...
Abstract Purpose To compare the efficacy of twin‐block (i.e., allows mouth opening) and fixed maintains closure) mandibular advancement splints (MASs) for treatment obstructive sleep apnea–hypopnea syndrome (OSA). Materials Methods From 2011 to 2013, 23 patients with OSA in group, from 2013 2015, 29 MAS group were included. All underwent polysomnography before after 3 months treatment. The two sets polysomnographic cephalometric variables compared. Results A significant difference ( p <...
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) have been shown to prevent left ventricular remodeling improve outcomes of patients with heart failure (HF). This study aimed investigate whether the use ACEi/ARB could be associated HF recovered ejection fraction (HFrecEF) in dilated cardiomyopathy (DCM).
The management of chronic thromboembolic pulmonary hypertension (CTEPH) has advanced significantly in recent years, thereby improving patient prognosis. However, the impact cancer on outcomes patients with CTEPH under current treatment remains unclear. This study aimed to investigate prevalence and determine how comorbid affects their prognosis clinical course.
An inverse relationship exists between hospital case volume and mortality in patients with heart failure (HF). However, performance factors associated HF have not been examined. We aimed to identify these using exploratory factor analysis assess the 7-day, 30-day, in-hospital among Japan.
Angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) have been shown to be associated with recovery of cardiac function in patients dilated cardiomyopathy (DCM). The aim this study was assess comparative effectiveness ACEis vs. ARBs on left ventricular ejection fraction (LVEF) among DCM.We analysed the clinical personal records DCM, a national database Japanese Ministry Health, Labour and Welfare, from 2003 2014. Patients LVEF < 40% either were...