A5043550992- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Cardiovascular and exercise physiology
- Obstructive Sleep Apnea Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Neuroscience of respiration and sleep
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
Fukui-ken Saiseikai Hospital
2015-2024
Saiseikai Fukuoka General Hospital
2020-2022
Japanese Circulation Society
2015-2019
Kyushu Hospital
2016-2017
Kyushu University Hospital
2016
St Mary's Hospital
2016
Japanese Red Cross Fukuoka Hospital
2016
Kyushu University
1995-2010
Jefferson College
2005
University of Pittsburgh
2000-2003
Studies in vitro have suggested that inflammatory cytokines may play an important role the pathogenesis of atherosclerosis. However, little is known about their effects vivo. Thus, present study was designed to determine vivo what histological and functional changes be induced by chronic treatment with IL-1 beta, one major cytokines, also clarify mechanisms are involved those changes. Under aseptic conditions, proximal segments left porcine coronary arteries were gently wrapped cotton mesh...
Abstract The aim of the present study was to investigate effects long-term blockade nitric oxide synthesis with l -arginine analogue N ω −nitro- methyl ester (L-NAME) for 8 weeks on coronary vascular and myocardial structural changes. Four groups Wistar-Kyoto rats were studied: those no treatment, treated L-NAME 1 g/L (3.7 mmol/L in drinking water), 0.1 (0.37 1.0 hydralazine 120 mg/L (0.6 water). After weeks, heart excised, degrees changes arteries (wall-to-lumen ratio perivascular...
Background —Transgenic mice with cardiac-specific overexpression of tumor necrosis factor (TNF)-α develop dilated cardiomyopathy. The present study was designed to evaluate therapeutic effects adenovirus-mediated neutralization TNF-α on this model. Methods and Results —An adenovirus encoding the 55-kDa TNF receptor–IgG fusion protein (AdTNFRI) injected intravenously into 6-week-old transgenic mice, which resulted in high levels TNFRI both plasma myocardium. AdTNFRI did not reverse...
Epidemiological evidence suggests that the prognosis of heart failure in women is better than men. In our murine model dilated cardiomyopathy arising from cardiac-specific overexpression TNF-α, 6-month survival rate was significantly females males. Young female transgenic mice exhibited left ventricular wall thickening without dilatation, whereas age-matched male hearts were markedly dilated. Basal and isoproterenol-stimulated fractional shortening preserved mice, but not mice. Myocardial...
Abstract Objectives Coronary microvascular functional and structural obstructions (CMVO) after percutaneous coronary intervention (PCI) are a major cause of poor clinical outcomes in patients with acute syndrome. This study aimed to noninvasively diagnose the presence CMVO using non-contrast multiparametric cardiac magnetic resonance (CMR) myocardial infarction (AMI) who underwent PCI. Methods We retrospectively enrolled consecutive AMI PCI subsequent acute-phase CMR at our hospital. The...
Background — Tumor necrosis factor (TNF)-α has been implicated in the pathophysiology of congestive heart failure. A strain transgenic mice (TNF1.6) with cardiac-specific overexpression TNF-α develop Methods and Results To determine effect anti-TNF-α therapy this model, we studied 3 groups: TNF1.6 treated saline, wild-type neutralizing antibody (cV1q) from 6 to 12 weeks age. We used echocardiography compare cardiac hypertrophy, function, catecholamine response at age versus baseline (6...
Background Endothelium-derived nitric oxide (NO) is believed to regulate myocardial perfusion and structural changes in the vascular wall. Our objective was determine whether chronic inhibition of NO synthesis causes functional coronary arteries. Methods Results Coronary vasomotor response studied pigs before after oral administration antagonist N ω -nitro- l -arginine methyl ester (L-NAME) 30 mg · kg −1 d for 2 weeks. Chronic L-NAME treatment increased ( P <.01) arterial pressure but did...
We sought to investigate whether treatment with ezetimibe in combination statins improves coronary endothelial function target vessels artery disease patients after stenting.We conducted a multicenter, prospective, randomized, open-label, blinded-end point trial among 11 cardiovascular centers. From 2011 2013, 260 who underwent stenting were randomly allocated 2 arms (statin monotherapy, S versus [10 mg/d]+statin combinational therapy, E+S). defined vessel dysfunction as the primary...
Abstract Aims To examine the effects of a 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. Methods and results In this multicenter, prospective, randomized, open-label, blinded-endpoint investigator-initiated clinical trial, adults haemoglobin A1C (HbA1c) 6.0–10.0% (42–86 mmol/mol) were randomized equally to (50 mg daily) non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use standard-care (control group) for followed-up 24 months....
We recently developed a porcine model in which chronic, local treatment with interleukin-1β (IL-1β) causes coronary arteriosclerosis-like changes and hyperconstrictive responses. This study was designed to examine whether or not other major inflammatory cytokines [tumor necrosis factor-α (TNF-α) interleukin-1α (IL-1α)] might also cause similar responses those are associated alterations the smooth-muscle phenotypes. A segment of artery aseptically wrapped cotton mesh, absorbing IL-1β, TNF-α,...
Myocardial extracellular matrix remodeling regulated by metalloproteinases (MMPs) is implicated in the progression of heart failure. We hypothesized that MMP inhibition may modulate and prevent The effects inhibitor BB-94 (also known as batimastat) on expression, collagen deposition, denaturation, left ventricular structure function transgenic mice with cardiac-restricted overexpression tumor necrosis factor-α (TNF-α) (TNF1.6) were assessed. results showed reduced expression collagens,...
Transgenic (TG) TNF1.6 mice, which cardiac specifically overexpress tumor necrosis factor-alpha (TNF-alpha), exhibit heart failure (HF) and increased mortality, is markedly higher in young (<20 wk) males (TG-M) than females (TG-F). HF this model may be partly caused by remodeling of the extracellular matrix and/or structure/function alterations at single myocyte level. We studied left ventricular (LV) structure function using echocardiography LV morphometry, contractile function,...
Abstract Introduction Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary excretion. Currently, little known about clinical efficacies of dotinurad patients with hyperuricemia hypertension. The aim this study was to assess effects selective reabsorption inhibitor on serum uric acid (SUA) levels relevant vascular markers treated Methods This investigator-initiated, multicenter, prospective, single-arm,...
Tumor necrosis factor (TNF)-alpha plays a key role in the pathogenesis of septic shock syndrome, and myocardial TNF-alpha expression may contribute to this pathophysiology. We examined TNF-alpha-related cytokines chemokines mice exposed lipopolysaccharide (LPS) tested effects anti-TNF therapy on cytokine expression. Cytokine mRNA levels were measured by RNase protection assay, protein plasma myocardium assessed enzyme-linked immunosorbent assays. LPS (4 microg/g body wt ip) induced marked...
Background The intracellular mechanism for coronary artery spasm is still unknown. Since the protein kinase C (PKC)–mediated pathway and Ca 2+ release from sarcoplasmic reticulum (SR) are important mechanisms of vascular smooth muscle contraction, we examined possible role these two in pathogenesis our swine model vivo. Methods Results In 25 pigs, interleukin-1β (IL-1β) was applied chronically to arteries adventitia induce an inflammatory/proliferative lesion. Two weeks after operation,...
Background: We have previously demonstrated that the prevalence of metabolic syndrome in chronic heart failure (CHF) is more than double compared with general population Japan. However, impact physical activity on cardiovascular events CHF patients remains to be fully elucidated. Methods and Results: performed a prospective, nationwide large-scale multicenter study 9,178 stage A/B/C/D obtained baseline data for 7,292 yearly changes during 3-year follow-up period 4,353 patients. divided into...
Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality life shortened expectancy. In addition appropriate glycemic control, multi-factorial intervention for a wide range factors, such as hypertension dyslipidemia, crucial management diabetes. A recent cardiovascular outcome trial in patients higher demonstrated that SGLT2 inhibitor markedly reduced mortality, but not events. However, date there no...
Background We recently developed a porcine model in which chronic, local treatment with interleukin-1β (IL-1β) causes coronary arteriosclerotic changes and hyperconstrictive responses. Inflammatory cytokines are known to induce inducible NO synthase (iNOS) the vascular smooth muscle. This study was designed examine whether or not production of by iNOS has protective deleterious effect on artery vivo. Methods Results A segment aseptically wrapped cotton mesh absorbing IL-1β suspension....
The aim of this study was to validate a four-parameter risk model including 123I-meta-iodobenzylguanidine (MIBG) imaging, which previously developed for predicting cardiac mortality, in new cohort patients with chronic heart failure (CHF). Clinical and outcome data were retrospectively obtained from 546 (age 66 ± 14 years) who had undergone 123I-MIBG imaging heart-to-mediastinum ratio (HMR). mean follow-up time 30 20 months, the endpoint death. mortality predicted by compared actual 2-year...
We recently demonstrated that chronic treatment with IL-1 beta induces coronary arteriosclerotic changes and vasospastic responses to autacoids in pigs vivo those are importantly mediated by PDGF. The receptors for PDGF other major growth factors known have tyrosine kinase activity. therefore investigated the effects of a selective inhibitor, ST 638, on induced our swine model. Intimal thickening serotonin histamine were at site artery where was chronically locally applied. These...