A5052966356- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Diabetes Management and Research
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Pancreatic function and diabetes
- Eicosanoids and Hypertension Pharmacology
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Adipokines, Inflammation, and Metabolic Diseases
- Receptor Mechanisms and Signaling
Saga University
2016-2025
Japanese Society of Hypertension
2021-2025
Japanese Circulation Society
2019-2024
Ureshino Medical Center
2021-2023
The University of Tokyo
2001-2022
National Hospital Organization
2021
University of Miyazaki Hospital
2020
Saiseikai Fukuoka General Hospital
2019
Otsuka Pharmaceutical (Spain)
2019
Electronic Product Services (Czechia)
2019
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to endothelium-derived hyperpolarizing factor. isoform CYP2J2 was cloned and identified as a potential source EETs in human endothelial cells. Physiological concentrations or overexpression decreased cytokine-induced cell adhesion molecule expression, prevented leukocyte the vascular wall by mechanism involving inhibition transcription factor NF-κB IκB kinase....
Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. The hypertrophic process mediated, in part, by small G proteins the Rho family. We hypothesized that statins, inhibitors 3-hydroxy-3-methylglutaryl-CoA reductase, inhibit cardiac blocking isoprenylation. treated neonatal rat myocytes with angiotensin II (AngII) without simvastatin (Sim) found Sim decreased AngII-induced protein content, [3H] leucine uptake, atrial natriuretic factor (ANF) promoter activity. These...
Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients nonischemic failure.Sixty-three symptomatic, nonischemic, dilated cardiomyopathy were randomly divided into 2 groups. One group received simvastatin (n=24), the other placebo (n=27). initial...
The mechanism by which platelet-derived growth factor (PDGF) regulates vascular smooth muscle cell (SMC) DNA synthesis is unknown, but may involve isoprenoid intermediates of the cholesterol biosynthetic pathway. Inhibition with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, simvastatin (Sim, 1–10 μm), inhibited PDGF-induced SMC >95%, retinoblastoma gene product hyperphosphorylation 90%, and cyclin-dependent kinases (cdk)-2, -4, -6 activity 80 ± 5, 50 3, 48 3%, respectively. This...
Background Small caliber vascular prostheses are not clinically available because synthetic lack endothelial cells which modulate platelet activation, leukocyte adhesion, thrombosis, and the regulation of vasomotor tone by production vasoactive substances. We developed a novel method to create scaffold-free tubular tissue from multicellular spheroids (MCS) using "Bio-3D printer"-based system. This system enables creation pre-designed three-dimensional structures computer controlled robotics...
Heart failure (HF) and atrial fibrillation (AF) are growing in prevalence worldwide. Few studies have assessed to what extent stage 1 hypertension the 2017 American College of Cardiology/American Association blood pressure (BP) guidelines is associated with incident HF AF.Analyses were conducted a nationwide health claims database collected JMDC Claims Database between 2005 2018 (n=2 196 437; mean age, 44.0±10.9 years; 58.4% men). No participants taking antihypertensive medication or had...
Abstract The SELECT trial previously reported a 20% reduction in major adverse cardiovascular events with semaglutide ( n = 8,803) versus placebo 8,801) patients overweight/obesity and established disease, without diabetes. In the present study, we examined effect of once-weekly 2.4 mg on kidney outcomes trial. incidence pre-specified main composite endpoint (death from initiation chronic replacement therapy, onset persistent estimated glomerular filtration rate (eGFR) < 15 ml min −1 1.73...
This study aimed to histologically validate atrial structural remodelling associated with fibrillation.
Patients with overweight and obesity are at increased risk of death from multiple causes, including cardiovascular (CV) death, few therapies proven to reduce the risk.
Adiponectin (Acrp30), an adipocyte-derived protein, exists in serum as a trimer, hexamer, and high-molecular weight (HMW) form, including 12-18 subunits. Because HMW adiponectin may be biologically active, we measured it using novel enzyme-linked immunosorbent assay (ELISA) confirmed by gel filtration chromatography that the ELISA detected mainly with subunits, compared total concentration patients type 2 diabetes. We next investigated relationship between coronary artery disease (CAD) 280...
Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators inhibitors of inflammation. However, it not known whether genetic polymorphisms CYP2J2 associated with increased cardiovascular risks.All 9 exons gene its proximal promoter were sequenced 132 patients identify potential variants. Functional consequence a single nucleotide polymorphism (SNP) was...
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 (CYP) epoxygenases that have vasodilatory and anti-inflammatory properties. Here we report EETs additional fibrinolytic In vascular endothelial cells, physiological concentrations EETs, particularly 11,12-EET, or overexpression the epoxygenase, CYP2J2, increased tissue plasminogen activator (t-PA) expression by 2.5-fold without affecting inhibitor-1 expression. This increase in t-PA correlated with a 4-fold induction gene...
Adenosine is believed to be cardioprotective; however, it has not been elucidated whether the plasma adenosine level increased in chronic heart failure.Seventy-one patients attending a specialized failure clinic during 6-month period were grouped according cause of and New York Heart Association function class. There 40 with due ischemic diseases 31 valvular dilated cardiomyopathy. Control subjects consisted 64 healthy laboratory staff members without failure. We found that levels...