A5028447558- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Optical Coherence Tomography Applications
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Retinal Imaging and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Protease and Inhibitor Mechanisms
- Coronary Artery Anomalies
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Thrombus and Embolism
- Cardiac Health and Mental Health
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Central Venous Catheters and Hemodialysis
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Cardiac Fibrosis and Remodeling
Wakayama Medical University
2015-2024
Wakayama Rosai Hospital
2022
Christie's
2015
Creative Commons
2015
Kinan Hospital
2013
Akita University Hospital
2004
Spontaneous coronary artery dissection (SCAD) found typically in young females without classical risk factors is thought to be a very rare cause of acute syndrome (ACS). The prevalence SCAD ACS subjects has been unclear, probably due the nature angiography. aim this study was use optical coherence tomography (OCT) investigate ACS.This consisted 326 patients with (with or ST-segment elevation) who underwent OCT explore entire culprit artery. According findings, were divided into SCAD, plaque...
Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation.We retrospectively analyzed 319 patients who underwent OCT immediately implantation and scheduled 9- 12-month follow-up angiography. binary rate 10% (32/319) in the patients, 8.4% (32/382) lesions, 4.4% (33/744) segments. In segments at post stenting,...
Abstract Inflammatory mediators such as cytokines and chemokines are crucially involved in the development of abdominal aortic aneurysm (AAA). Here we report that CaCl 2 application into aorta induces AAA with intra-aortic infiltration macrophages well enhanced expression chemokine (C-C motif) ligand 3 (CCL3) MMP-9. Moreover, infiltrating express C-C receptor 5 (CCR5, a specific for CCL3) Both Ccl3 −/− mice Ccr5 but not Ccr1 exhibit exaggerated -inducced augmented macrophage MMP-9...
Background: Circulating monocytes can be divided into 2 subsets typically identified by the expression of CD14 and CD16. Although previous studies have shown that circulating contribute to progression coronary atherosclerotic lesions, relationship between severity artery disease (CAD) distinct monocyte has not previously been evaluated. We investigated CAD assessed angiography (CAG) in patients with stable angina pectoris (SAP). Methods Results: enrolled 125 who underwent diagnostic CAG....
A novel index of the functional severity coronary stenosis, quantitative flow ratio (QFR), may not consider amount viable myocardium in prior myocardial infarction (MI) because QFR is calculated from 3D angiography.Methods and Results:We analyzed (fixed-flow [fQFR] contrast-flow [cQFR]) fractional reserve (FFR) prior-MI-related arteries (n=75) non-prior-MI-related (n=75). Both fQFR cQFR directly correlated with FFR (fQFR: r=0.84, P<0.001; cQFR: r=0.88, P<0.001) r=0.91, r=0.94, P<0.001). was...
Quantitative flow ratio (QFR) is a novel physiological index of the severity coronary stenosis. The aim present study was to investigate relationship between QFR and instantaneous wave-free (iFR).We analyzed contrast-flow QFR, iFR, fractional reserve (FFR) in 100 arteries with intermediate stenosis.There high correlation (r=0.71, P<0.001) good agreement (mean difference: -0.09±0.11) iFR. Both iFR were correlated significantly FFR (r=0.89, P<0.001 r=0.76, P<0.001, respectively). mean absolute...
After the ligation of inferior vena cava (IVC) wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days resolved thereafter. Concomitantly, intrathrombotic gene expression Il6 was enhanced later than after IVC ligation. IL-6 protein detected mainly in F4/80-positive macrophages thrombus. When Il6-deficient (Il6-/-) mice were treated same manner, thrombus mass significantly larger WT mice. Moreover, recovery thrombosed blood flow markedly delayed Il6-/- compared with...
Objective- Deep vein thrombosis results from a combination of risk factors including genetic conditions, obesity, drugs, pregnancy, aging, and malignancy. We examined pathophysiological roles the TNF-α (tumor necrosis factor-α)-TNF-Rp55 factor receptor p55) axis in thrombus resolution using Tnfrp55-/- (TNF-Rp55-deficient) mice. Approach Results- On ligating inferior vena cava wild-type (WT) mice, venous thrombi formed grew progressively until 5 days but shrunk to <50% weight at day 14....
A clear understanding of the molecular mechanisms underlying hemodynamic stress-initiated cardiac hypertrophy is important for preventing heart failure. Interferon-γ (IFN-γ) has been suggested to play crucial roles in various diseases other than immunological disorders by modulating expression myriad genes. However, involvement IFN-γ pathogenesis still remains unclear.
Cholesterol crystals (CCs) are frequently found at the site of acute myocardial infarctions (AMIs), but role CCs in onset AMI remains unclear due to lack validated vivo imaging tools. The aim this study was validate ability optical coherence tomography (OCT) detect and compare prevalence distribution patients with AMIs stable angina pectoris. Approach Results: CC assessment using OCT were compared histopathology results 45 coronary samples. We investigated 152 consecutive 41 single...
In 2008, the Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina) [[1]JCS Joint Working Group (JCS 2008): digest version.Circ J. 2010; 74: 1745-1762Crossref PubMed Scopus (231) Google Scholar] were developed by Japanese Circulation Society, revised version was published in 2013 [[2]JCS 2013): 2014; 78: 2779-2801Crossref Scholar]. Since then, new findings from various fields such as coronary microvascular dysfunction (CMD), biomarkers, imaging,...
While patients with acute coronary syndrome (ACS) presenting non-obstructive artery disease (CAD) are at high risk for cardiovascular mortality and morbidity, detailed lesion characteristics unclear. The aim of this study was to investigate the prognosis ACS CAD. This consisted 82 consecutive without obstructive CAD who underwent optical coherence tomography (OCT). Based on presence high-risk lesions (HL) in culprit artery, we classified into two groups: HL group non-high-risk (NHL) group. A...
Background:Coronary adventitia harbors a wide variety of components, such as inflammatory cells and vasa vasorum (VV). Adventitial VV initiates the development coronary artery diseases an outside-in supply route inflammation. We have recently demonstrated that drug-eluting stent implantation causes enhancement formation, with extending to edges in porcine arteries, also optical frequency domain imaging (OFDI) is capable visualizing humans vivo. However, it remains be fully validated whether...
Early clinical presentation of ST-segment-elevation myocardial infarction (STEMI) and non-ST-segment-elevation affects patient management. Although local inflammatory activities are involved in the onset MI, little is known about their impact on early presentation. This study aimed to investigate whether affect presentation.This comprised 94 17 patients with MI (STEMI, 69; non-STEMI, 25) stable angina pectoris, respectively. We simultaneously investigated culprit lesion morphologies using...
The aim of the present study was to evaluate feasibility optical coherence tomography (OCT) for measurement vessel area in coronary arteries with lipid-rich plaque as compared intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 80 artery segments on OCT and non-attenuated IVUS. According lipid arc OCT, plaques were classified into 4 groups: group 1, ≤90°; 2, 90°<lipid arc≤180°; 3, 180°<lipid arc≤270°; 4, >270°. Vessel circular arcs that could not be identified due signal...