A5045934626- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Nutrition and Health in Aging
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Frailty in Older Adults
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Cardiac pacing and defibrillation studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- COVID-19 Clinical Research Studies
- Cardiac electrophysiology and arrhythmias
Kumamoto University
2008-2025
Yokohama City University
2015-2024
Kumamoto University Hospital
2023-2024
Yokohama City University Medical Center
2015-2024
Hokkaido University
2023
Matsumoto University
2023
Mayo Clinic in Arizona
2014-2021
Hospital Universitario Virgen Macarena
2017
Mayo Clinic
2014-2016
Vanderbilt University Medical Center
2016
Adipose tissue secretes a variety of proteins into the bloodstream. We have previously reported novel cDNA, apM1 (adipose most abundant gene transcript 1), which is specifically and abundantly expressed in adipose [1]. Primary structure analysis predicted that product possesses significant homology to collagens VIII, X complement factor C1q, we named it adiponectin. In current study, analyzed characteristics adiponectin vitro vivo. Adiponectin protein was proved be secreted medium when cDNA...
Cannabinoid 1 (CB1) receptor blockade with rimonabant represents a clinical therapeutic strategy for obesity. Recently, the role of endocannabinoid system has been described in peripheral organs. We sought to determine whether could be involved human atherosclerosis and CB1 modulate proinflammatory activity macrophages.mRNA expression levels coronary atherectomy samples were significantly higher patients unstable angina than those stable (3.62+/-2.96-fold; n=7; P<0.05). Immunoreactive area...
Background Endothelial dysfunction is a key component of vascular vulnerability. Reactive hyperemia index ( RHI ), as assessed by the peripheral arterial tonometry, can noninvasively evaluate endothelial function. This study was designed to determine additional prognostic value function Synergy Between PCI With Taxus and Cardiac Surgery Score SYNTAX sc) Framingham Risk FRS ) in predicting cardiovascular events high‐risk patients. Methods Results We undertook two‐center prospective 528 stable...
Blood glucose variability is receiving considerable attention as a new risk factor for coronary artery disease. This study aimed to investigate the association between blood and plaque tissue characteristics.In 57 patients with acute syndrome, integrated backscatter intravascular ultrasound (IB-IVUS) gray-scale IVUS were performed before balloon dilatation or stent implantation in culprit vessels. Standard indices evaluated volume index (volume/length), components measured by IB-IVUS percent...
Cachexia, characterized by loss of muscle with or without fat mass, is a poor prognostic factor in patients heart failure (HF). However, there limited investigation on the impact and mass separately HF. We hypothesized that have different effects prognosis
Angina without significant stenosis, or nonobstructive coronary artery disease, attracts clinical attention. Microvascular spasm (microvascular CAS) can cause disease. We investigated the features of microvascular CAS and therapeutic efficacy calcium channel blockers.Three hundred seventy consecutive, stable patients with suspected angina presenting arteries (<50% diameter) in angiography were intracoronary acetylcholine provocation test, simultaneous measurements transcardiac lactate...
Impaired glucose metabolism is an established risk factor for coronary artery disease. Previous studies revealed that glycemic variability (GV) also important in patients with acute syndrome (ACS). We explored the association between GV and prognosis ACS. A total of 417 ACS who received reperfusion wore a continuous monitoring system (CGMS) stable phase after admission were monitored at least 24 consecutive h. The mean amplitude excursion (MAGE) was calculated as marker GV. divided into two...
Background and Objective MicroRNAs (miRNAs) have been shown to be associated with various physiological pathological conditions, including inflammation cardiovascular disease, but little is known about their relationship the presence of coronary artery disease (CAD) severity. Methods A total 195 consecutive subjects who underwent angiography for chest pain evaluation were enrolled in this study. In CAD patients severity lesions was assessed by number diseased vessels Synergy between PCI...
The aim of this study was to investigate the association between hypothyroidism and major adverse cardiovascular cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI).Two thousand four hundred thirty who underwent PCI were included. Subjects divided into two groups: (n = 686) defined either as a history or thyroid-stimulating hormone (TSH) ≥5.0 mU/mL, euthyroidism 1744) no and/or 0.3 mU/mL ≤ TSH < 5.0 mU/mL. Patients with further categorized untreated 193),...
Negative T waves in precordial leads often occur patients with acute coronary syndrome (ACS), but are also found pulmonary embolism (APE) and Takotsubo cardiomyopathy (TC). Because the clinical features of these two diseases mimic those ACS, differential diagnosis is essential to select an appropriate treatment strategy improve outcomes. This study aimed clarify differences negative among APE TC. We studied admission ECGs 300 (198 ACS caused by left anterior descending artery disease, 81 21...