A5091110999- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Laser-Plasma Interactions and Diagnostics
- Acute Myocardial Infarction Research
- Nitric Oxide and Endothelin Effects
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Computational Fluid Dynamics and Aerodynamics
- Cardiac Ischemia and Reperfusion
- Ultrasound and Hyperthermia Applications
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Pain Management and Treatment
- Cardiac Arrhythmias and Treatments
- Magnetic confinement fusion research
- Laser-Matter Interactions and Applications
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
- Gas Dynamics and Kinetic Theory
Tohoku University Hospital
2013-2025
Nagoya University
2023-2025
Tohoku University
2015-2024
National Institutes for Quantum Science and Technology
2020-2023
Osaka University
2016-2019
Imperial College London
2017
Suzuki (Japan)
2017
Massachusetts General Hospital
2017
National Cerebral and Cardiovascular Center
2017
Japan Radioisotope Association
2017
Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and patients with severe angina pectoris. Methods Results: To further confirm the effectiveness safety of SW therapy, 8 pectoris were treated double-blind, placebo-controlled cross-over manner. but not placebo, significantly chest pain symptoms cardiac function without any complications or adverse effects. Conclusions: Extracorporeal is an effective, safe non-invasive therapeutic option...
Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1null mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood. We found redox stress plasma biomarker 8-isoprostane was elevated in caveolin-1null mice, and discovered siRNA-mediated caveolin-1 knockdown endothelial cells promoted significant increases intracellular H2O2. Mitochondrial ROS production increased after knockdown;...
The quest for the inertial confinement fusion (ICF) ignition is a grand challenge, as exemplified by extraordinary large laser facilities. Fast isochoric heating of pre-compressed plasma core with high-intensity short-pulse an attractive and alternative approach to create ultra-high-energy-density states like those found in ICF sparks. This avoids quench caused hot spark mixing surrounding cold fuel, which crucial problem currently pursued scheme. High-intensity lasers efficiently produce...
Objective— Left ventricular (LV) remodeling after acute myocardial infarction still remains an important issue in cardiovascular medicine. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) therapy improves ischemia a pig model of chronic through enhanced angiogenesis. In the present study, we aimed to demonstrate whether LIPUS also ameliorates LV and if so, elucidate underlying molecular mechanisms involved beneficial effects LIPUS. Approach Results— examined on...
Background— Erythropoietin (Epo) receptors (EpoRs) are expressed in the heart. We have recently demonstrated that endogenous Epo-EpoR system plays an important protective role myocardial ischemia mice and humans. In present study, we tested our hypothesis nonhematopoietic cells also a against pressure overload–induced cardiac dysfunction vivo. Methods Results— Transgene-rescued EpoR-null mutant ( EpoR −/− rescued ) express exclusively hematopoietic were subjected to transverse aortic...
Objectives Left ventricular (LV) remodeling after acute myocardial infarction (AMI) is associated with a poor prognosis and an impaired quality of life. We have shown earlier that low-energy extracorporeal cardiac shock wave (SW) therapy improves chronic ischemia in pigs humans also ameliorates LV pig model AMI induced by permanent coronary ligation. However, the current clinical setting, most patients receive reperfusion therapy. Thus, this study we examined whether our SW...
A petawatt laser for fast ignition experiments (LFEX) system [N. Miyanaga et al., J. Phys. IV France 133, 81 (2006)], which is currently capable of delivering 2 kJ in a 1.5 ps pulse using 4 beams, has been constructed beside the GEKKO-XII facility demonstrating efficient heating dense plasma up to temperature under auspices Fast Ignition Realization EXperiment (FIREX) project [H. Azechi Nucl. Fusion 49, 104024 (2009)]. In FIREX experiment, cone attached spherical target containing fuel...
Whether there are prognostic links between coronary morphologies and functional abnormalities was examined in ischemia nonobstructive artery disease (INOCA) patients. Although INOCA has attracted much attention, little is known about the impact of this disorder. A total 329 consecutive patients were enrolled underwent spasm provocation testing combined with lactate sampling for diagnosis epicardial microvascular (MVS). On basis tests, classified into 4 groups: a control group without or MVS...
The prevalence of Alzheimer's disease (AD) has been rapidly increasing worldwide. We have developed a novel angiogenic therapy with low-intensity pulsed ultrasound (LIPUS), which is effective and safe in animal models AD vascular dementia. performed two trials LIPUS for (mild cognitive impairment due to mild AD); roll-in open trial safety, randomized, double-blind, placebo-controlled (RCT) efficacy safety. was whole brain through the bilateral temporal bones one hour 3 times week as session...
Abstract Aims This study aimed to elucidate age‐stratified clinical profiles and outcomes in patients with heart failure (HF) preserved left ventricular ejection fraction (LVEF) (HFpEF). Methods results The Chronic Heart Failure Registry Analysis the Tohoku District‐2 (CHART‐2) Study included 2824 consecutive HFpEF LVEF ≥ 50% (mean age 69.0 ± 12.3 years; 67.7% male) a median follow‐up of 9.8 years. We stratified them into five groups: ≤54 ( N = 349, 12.4%), 55–64 529, 18.7%), 65–74 891,...
In this paper, a kinetic energy and entropy preserving (KEEP) scheme, originally designed for compressible fluid dynamics, is extended to encompass magnetohydrodynamics (MHD), where the magnetic included in total equation consistent with that derived from induction equation. The spatial derivative discretized by central finite difference, resulting preservation of solenoidal constraint field. Numerical fluxes momentum related field can be Lorentz force constraint, even discrete form. results...
Although sudden cardiac death (SCD) generally occurs more frequently in men than women, there are limited data on sex differences SCD patients with chronic heart failure (HF) across a range of left ventricular ejection fraction (LVEF). We examined incidence, timing, and risk factors 4,683 HF (3,186 men, 1,497 women) from multicenter prospective observational cohort study (CHART-2). Over median follow-up 8.8 years after enrollment, were 215 SCDs (160 55 women). The incidence rates women 6.1...
Background:The importance of adventitial inflammation has been implicated for the pathogenesis coronary artery disease. However, roles changes in drug-eluting stent (DES)-induced hyperconstriction remain largely unknown. In present study, this issue pigs vivo with a special reference to vasa vasorum (VV) formation and Rho-kinase activation, central mechanism vasospasm, was examined.Methods Results:Each animal received sirolimus-eluting (SES) biolimus A9-eluting (BES), one left anterior...
Abstract Aims Current approaches to classify chronic heart failure (HF) subpopulations may be limited due the diversity of pathophysiology and co‐morbidities in HF. We aimed elucidate clusters patients with HF by data‐driven machine learning a hospital‐based registry. Methods results A total 4649 broad spectrum left ventricular ejection fraction (LVEF) CHART‐2 (Chronic Heart Failure Analysis Registry Tohoku District‐2) study were enrolled this study. Chronic classified using random forest...
Elevated levels of serum retinol-binding protein 4 (RBP4) contribute to insulin resistance and correlate with increased prevalence hypertension myocardial infarction. We sought determine whether lowering RBP4 would improve blood pressure (BP) protect against obesity- or angiotensin (Ang)-II-induced hypertension. Systolic diastolic BP were lower in the RBP4-knockout (RBP4-KO) mice higher RBP4-overexpressing (RBP4-Tg) compared wild-type (WT) littermates. Carbachol-induced vasodilatation was...
Objective- Secondary prevention for recurrent myocardial infarction (MI) is one of the most important therapeutic goals in patients with old MI (OMI). Although statins are widely used this purpose, there remains considerable residual risk even after LDL (low-density lipoprotein cholesterol) well controlled by statins. Approach and Results- We examined clinical impacts nHDL (nonhigh-density its major components triglyceride as risks acute recurrence, using database our CHART (Chronic Heart...
In 2008, the Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina) [[1]JCS Joint Working Group (JCS 2008): digest version.Circ J. 2010; 74: 1745-1762Crossref PubMed Scopus (231) Google Scholar] were developed by Japanese Circulation Society, revised version was published in 2013 [[2]JCS 2013): 2014; 78: 2779-2801Crossref Scholar]. Since then, new findings from various fields such as coronary microvascular dysfunction (CMD), biomarkers, imaging,...
Background: Vasospastic angina (VSA) is known to exhibit circadian variation with an early morning peak. We examined whether Rho-kinase activity in circulating leukocytes, which a useful biomarker for disease assessment of VSA, exhibits patients VSA. Methods and Results: In consecutive 31 VSA (M/F 23/8, 57±13 [SD] years) 18 non-VSA 8/10, 57±14 years), we measured leukocytes at 6:00, 12:00 21:00. also the relationship between coronary vasomotor responses during provocation test. was...
Time-resolved compression of a laser-driven solid deuterated plastic sphere with cone was measured flash Kα x-ray radiography. A spherically converging shockwave launched by nanosecond GEKKO XII beams used for while 4.51 keV Ti backlighter produced high-intensity, picosecond laser LFEX (Laser Fast ignition EXperiment) near peak Areal densities the compressed core were inferred from two-dimensional backlit images recorded narrow-band spherical crystal imager. The maximum areal density in...