A5041229089- Rheumatoid Arthritis Research and Therapies
- Ultrasound Imaging and Elastography
- Cytokine Signaling Pathways and Interactions
- Fatty Acid Research and Health
- IgG4-Related and Inflammatory Diseases
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine Tumor Research Advances
- Bone health and treatments
- Bone Metabolism and Diseases
- Cardiovascular Health and Disease Prevention
- NF-κB Signaling Pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune Response and Inflammation
- Sarcoidosis and Beryllium Toxicity Research
- Soft tissue tumor case studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Photoacoustic and Ultrasonic Imaging
- Vasculitis and related conditions
- Ultrasound and Hyperthermia Applications
- Toxin Mechanisms and Immunotoxins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- HER2/EGFR in Cancer Research
- Inflammatory Myopathies and Dermatomyositis
The University of Tokyo
2023
University of Toyama
2009-2021
Tohoku University
2015-2020
Hosei University
2017
Hiroshima University
2015
Hiroshima University Hospital
2015
Dana-Farber Cancer Institute
2015
Kyoto University
2010-2014
Kyoto College of Graduate Studies for Informatics
2012-2013
Tohoku Medical and Pharmaceutical University
1993-2005
Objective— Left ventricular (LV) remodeling after acute myocardial infarction still remains an important issue in cardiovascular medicine. We have recently demonstrated that low-intensity pulsed ultrasound (LIPUS) therapy improves ischemia a pig model of chronic through enhanced angiogenesis. In the present study, we aimed to demonstrate whether LIPUS also ameliorates LV and if so, elucidate underlying molecular mechanisms involved beneficial effects LIPUS. Approach Results— examined on...
Objective Acute-onset diffuse interstitial lung disease (AoDILD) in patients with rheumatoid arthritis (RA) has been a serious concern, especially for those under treatment biological agents which may affect the presentation and outcome of AoDILD, including Pneumocystis pneumonia (PCP). Therefore, we conducted retrospective, multi-center study AoDILD RA receiving agents. Methods Patients who developed while (infliximab, etanercept, adalimumab tocilizumab) were enrolled study. Definite PCP...
Abstract n‐3 Polyunsaturated fatty acids abundant in marine lipids suppress certain inflammatory and immune reactions, dietary lipid supplements have antiinflammatory effects experimental human autoimmune disease. Previous work by other investigators demonstrated that suppressed production of cytokines from stimulated peripheral blood mononuclear cells ex vivo . The present study further documents the ability to inhibit cytokine formation, part defines mechanism inhibition interleukin‐1β...
'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being phenotype IgG4-related disease. To clarify the characteristics respiratory involvement associated MD, we retrospectively assessed 25 patients 11 (44%) whom had allergic symptoms, and 7 (28%) complained problems. Thirteen (52%) presented pulmonary and/or mediastinal lesions (P-MD) on chest computed tomography (CT), limited to lacrimal salivary glands (L-MD). Mean...
Objective Interleukin-11 (IL-11), an IL-6-type cytokine, is thought to be involved in bone resorption via osteoclast differentiation. Here, we characterized the combined effect of IL-1α and tumor necrosis factor α (TNFα), major cytokines rheumatoid synovium, on production IL-11 by cultured synovial fibroblasts (RSFs). Methods The amounts IL-11, IL-6, prostaglandin E2 (PGE2) were measured enzyme-linked immunosorbent assay. messenger RNA (mRNA) levels determined Northern blotting. Protein...
'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being phenotype IgG4-related disease. To clarify the characteristics respiratory involvement associated MD, we retrospectively assessed 25 patients 11 (44%) whom had allergic symptoms, and 7 (28%) complained problems. Thirteen (52%) presented pulmonary and/or mediastinal lesions (P-MD) on chest computed tomography (CT), limited to lacrimal salivary glands (L-MD). Mean...
Objective To investigate the reactivity of monoclonal anti–citrullinated protein antibody (ACPA) obtained from peripheral blood B cells rheumatoid arthritis (RA) patients with human autoantigens as well environmental proteins by determining essential epitope for ACPA. Methods A ACPA (cyclic citrullinated peptide 1 [CCP‐Ab1]) was screening lymphocytes 31 RA using a novel antibody–secreting cell (ASC) system, immunospot‐array assay on chip. The CCP‐Ab1 determined mapping. Then, human,...
Abstract We propose a method for assessment of the degree red blood cell (RBC) aggregation using backscattering property high-frequency ultrasound. In this method, scattering RBCs is extracted from power spectrum RBC echoes normalized by that posterior wall vein. an experimental study phantom, employing proposed sizes microspheres 5 and 20 µm in diameter were estimated to have mean values 4.7 17.3 standard deviations 1.9 1.4 µm, respectively. vivo study, we compared results between three...
Non-invasive identification of ischemic regions is important for diagnosis and treatment myocardial infarction. In the present study, ultrasound measurement was applied to interventricular septum three open-chest swine hearts. The properties contraction response were compared between normal acute conditions, where condition originated from direct avascularization left anterior descending (LAD) coronary artery. result showed that propagated basal side apical along septum. estimated...
To characterise the effect of interleukin-4 (IL-4) on biosynthesis cyclo-oxygenases I (COX I) and II II), rate limiting enzymes synthesis prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells.Adherent cells were obtained from synovium by collagenase digestion. The concentrations PGE2 culture supernatants determined enzyme linked immunosorbent assay. protein mRNA COX Western blotting reverse transcription polymerase chain reaction, respectively.Freshly produced large amounts...
A 54-year-old woman with suspected low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type the eyelids underwent rituximab-containing chemotherapy. She initially responded to rituximab therapy, but later experienced two recurrences over a 3-year period. Biopsy specimens and review her previous histology revealed that she had immunoglobulin G4-related disease at initial presentation. Although IgG4-related seems respond well long-term follow up, including monitoring, is needed...
A 54-year-old woman with suspected low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type the eyelids underwent rituximab-containing chemotherapy. She initially responded to rituximab therapy, but later experienced two recurrences over a 3-year period. Biopsy specimens and review her previous histology revealed that she had immunoglobulin G4-related disease at initial presentation. Although IgG4-related seems respond well long-term follow up, including monitoring, is needed...
Whether tumor progression locus 2 (Tpl2)/cancer Osaka thyroid (Cot) protein kinase participates in osteoclastogenesis from receptor activator of nuclear factor-kappaB ligand (RANKL)-stimulated monocytes/macrophages remains elusive. To clarify this, a selective and potent inhibitor Tpl2, 1,7-naphtyridine-3-carbonitrile, was used. When RAW264.7 cells were stimulated with RANKL, Tpl2 found to be activated. Under this condition, the suppressed dose-dependent manner. This due blockade...
The murine peptidylarginine deiminase (PAD) has five isoforms encoded by different genes and participates in a variety of cellular functions through the citrullination target proteins. crystal structure human PAD4 with dimeric form was previously solved because enzyme's relevance to rheumatoid arthritis. PAD6, abundant mouse oocytes eggs, is believed take part early events embryogenesis, but its biochemical properties are little understood. Here we have purified characterized recombinant...