A5070737875- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Protein Kinase Regulation and GTPase Signaling
- Diabetes and associated disorders
- Peroxisome Proliferator-Activated Receptors
- Diabetes Management and Research
- Lung Cancer Treatments and Mutations
- Sirtuins and Resveratrol in Medicine
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Growth Hormone and Insulin-like Growth Factors
- Lung Cancer Research Studies
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Gut microbiota and health
- IgG4-Related and Inflammatory Diseases
University of Toyama
2016-2025
Toyama University Hospital
2015-2024
Toyama College
2021-2024
Takatsuki General Hospital
2024
Health First
2009-2017
Hiroshima University
2015
Hiroshima University Hospital
2015
Dana-Farber Cancer Institute
2015
The University of Tokyo
2000-2009
Japan Science and Technology Agency
2002-2007
The serine/threonine kinase Akt has been implicated in the control of cell survival and metabolism. Here we report disruption most ubiquitously expressed member akt family genes, akt1 , mouse. Akt1 −/− mice are viable but smaller when compared to wild-type littermates. In addition, life span mice, upon exposure genotoxic stress, is shorter. However, do not display a diabetic phenotype. Increased spontaneous apoptosis testes, attenuation spermatogenesis observed male mice. also thymi...
Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles MCP-1 overexpression in adipose, we generated transgenic mice by utilizing adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These had higher plasma increased macrophage accumulation adipose tissues, as confirmed immunochemical, flow cytometric, gene analyses. Tumor necrosis factor-α interleukin-6 mRNA levels white non-esterified fatty...
An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the gene (APM1) located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 (P = 0.003 P 0.002, respectively). Subjects G/G genotype position or had significantly increased risk (odds ratio 1.70 [95% CI 1.09-2.65] 2.16...
OBJECTIVE To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions insulin sensitivity. RESEARCH DESIGN AND METHODS The number and expressions marker genes for M1 M2 from mouse epididymal fat were analyzed using flow cytometry after mice had been subjected to a high-fat diet (HFD) pioglitazone treatment. RESULTS Most CD11c-positive CD206-positive in clearly separated cytometry. exhibited completely gene expression patterns. Not only numbers ATMs...
Peroxisome proliferator-activated receptor (PPAR) γ is a ligand-activated transcription factor and member of the nuclear hormone superfamily that thought to be master regulator fat storage; however, relationship between PPARγ insulin sensitivity highly controversial. We show here supraphysiological activation by agonist thiazolidinediones (TZD) markedly increases triglyceride (TG) content white adipose tissue (WAT), thereby decreasing TG liver muscle, leading amelioration resistance at...
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 -R2 serve receptors for adiponectin mediate increased fatty acid oxidation glucose uptake adiponectin. In the present study, we examined expression levels roles of AdipoR1/R2 in several physiological pathophysiological states such fasting/refeeding, obesity, insulin resistance. Here show target organs, skeletal muscle liver, significantly...
To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. IRS-2-/- showed resistance and defect insulin-stimulated signaling pathway liver but not skeletal muscle. Despite resistance, amount beta-cells was reduced 83% that which marked contrast 85% increase IRS-1-deficient (IRS-1-/-...
The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy adipocytes. However, little is known about how adipocytes, adipocyte precursors, blood vessels, stromal cells interact with one another to achieve adipogenesis.We have developed a confocal microscopy-based method three-dimensional visualization intact living that enabled us simultaneously evaluate angiogenesis adipogenesis db/db mice.We found differentiation takes place within cell clusters (which...
Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of β cell–specific Gck (Gck+/–) causes impaired secretion to glucose, although the animals have normal cell mass. When high-fat (HF) diet, wild-type showed marked hyperplasia, whereas Gck+/– demonstrated decreased replication insufficient hyperplasia despite showing similar degree resistance. DNA chip analysis revealed receptor substrate 2 (Irs2) expression HF diet–fed...
Thiazolidinediones have been shown to up-regulate adiponectin expression in white adipose tissue and plasma levels, these up-regulations proposed be a major mechanism of the thiazolidinedione-induced amelioration insulin resistance linked obesity. To test this hypothesis, we generated knock-out (adipo-/-) ob/ob mice with C57B/6 background. After 14 days 10 mg/kg pioglitazone, diabetes were significantly improved association significant up-regulation serum levels. Amelioration was attributed...
The current guideline represents the 6th edition of 'Japanese Clinical Practice Guideline for Diabetes' which has been revised every three years since its first appearance in 2004 to promote evidence-based, rational, efficient and consistent clinical practice diabetes. Of note, dramatic progress made recent diabetes research practice, includes approval antidiabetic agents with novel mechanisms action along publication trial results these drugs, diagnostic therapeutic devices, such as...