A5004508919- Inflammatory Bowel Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Polyamine Metabolism and Applications
- Microscopic Colitis
- Adipose Tissue and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Protein Hydrolysis and Bioactive Peptides
- Hormonal Regulation and Hypertension
- Autoimmune and Inflammatory Disorders
- Microbial Community Ecology and Physiology
- Diet and metabolism studies
- Microbial Metabolic Engineering and Bioproduction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Protease and Inhibitor Mechanisms
- Chronic Kidney Disease and Diabetes
- Vibrio bacteria research studies
- Helicobacter pylori-related gastroenterology studies
Mie University
2014-2024
Japan Fisheries Research and Education Agency
2010-2024
Mie University Hospital
2015-2023
Fukuoka University
2006-2021
Diabetes Australia
2005-2015
University Gastroenterology
2008-2013
Osaka City University
2013
Osaka Hospital
2013
Kyushu University
2013
Japan Agency for Marine-Earth Science and Technology
2012
OBJECTIVE— To investigate the usefulness of homeostasis model assessment as an index insulin resistance (HOMA-IR) for evaluating clinical course patients with type 2 diabetes. RESEARCH DESIGN AND METHODS— The HOMA-IR and its relationship assessed by hyperinsulinemic-euglycemic clamp study (clamp IR) were evaluated in 55 Japanese diabetes before after treatment. subjected to diet (∼1,440-1,720 kcal/day) exercise therapy (walking 10,000 steps daily) 6 weeks during their hospitalization....
To investigate the direct relationship of oxidative stress with obesity and insulin resistance in men, we measured plasma levels 8-epi-prostaglandin F2alpha (PGF2alpha) 14 obese 17 nonobese men evaluated their body mass index; fat weight; visceral, sc, total areas, by computed tomography; glucose infusion rate during a euglycemic hyperinsulinemic clamp study. Obese had significantly higher concentrations 8-epi-PGF2alpha than (P < 0.05). The were correlated index (r = 0.408; P 0.05), weight...
To clarify the significance of serum levels tumor necrosis factor-α (TNF-α) in mechanism insulin resistance, we studied 12 obese patients with noninsulin-dependent diabetes mellitus (NIDDM). We evaluated relationship TNF-α visceral, subcutaneous, and total fat areas measured by computed tomography (CT), resistance glucose infusion rate (GIR) observed during an euglycemic hyperinsulinemic clamp study. Controls consisted normal subjects nonobese NIDDM. were using a high sensitivity...
The purpose of this study was to investigate the association between visceral adiposity or triglyceride (TG) metabolism and insulin resistance in metabolically obese, normal weight (MONW) Japanese individuals with glucose tolerance.We evaluated body fat areas, lipid profiles, infusion rate (GIR) during a euglycemic-hyperinsulinemic clamp 20 MONW subjects (BMI <25 kg/m(2)and areas 100 cm(2)) tolerance. Body were measured by computed tomography scans. Control data obtained from kg/m(2) <100...
Abstract Vibrio vulnificus is an estuarine bacterium which the causative agent of both food‐borne disease and wound infection. Although V. commonly found in molluscan shellfish at high numbers, incidence relatively low, leading to hypothesis that not all strains are equally virulent. Unfortunately, there currently no easy test identify virulent this species. We have previously identified a 200 bp randomly amplified polymorphic DNA (RAPD) PCR amplicon associated with clinical isolates....
Abstract Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation idiopathic associated with high mortality. Excessive apoptosis lung epithelial cells occurs in acute exacerbation. We recently identified corisin, a proapoptotic peptide that triggers fibrosis. Here, we provide insights into the mechanism underlying processing and release corisin. Furthermore, demonstrate anticorisin monoclonal antibody ameliorates by significantly inhibiting human...
OBJECTIVE: To investigate the relationship between circulating level of active ghrelin and abdominal adiposity, serum levels insulin or resistance in patients with type 2 diabetes mellitus. DESIGN: We measured plasma form 18 obese nonobese mellitus using a radioimmunoassay (RIA) kit. Body fat accumulation was by computed tomography (CT) glucose infusion rate (GIR) during an euglycemic hyperinsulinemic clamp study. RESULTS: Plasma were significantly decreased compared patients. There...
ABSTRACT The lipid compositions of barophilic bacterial strains which contained docosahexaenoic acid (DHA [22:6n-3]) were examined, and the adaptive changes these analyzed in response to growth pressure. In facultatively strain 16C1, phosphatidylethanolamine (PE) phosphatidylglycerol (PG) major components had same fatty chains. However, PE, monounsaturated acids such as hexadecenoic components, DHA accounted for only 3.7% total acids, while PG, 29.6% acids. an increase pressure amounts...
Background and Aim Endoscopic balloon dilation ( EBD ) is an alternative to surgery for small bowel strictures of patients with C rohn's disease CD ). However, little known about the long‐term efficacy . The aim present study was clarify outcome in Methods Subjects comprised 65 who underwent intestinal were followed up at least 6 months. All subjects had obstructive symptoms as a result strictures. Short‐term success defined technical disappearance symptoms. short‐term rate , its safety...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis lung alveolar epithelial cells plays role in progression. This intractable associated with increased abundance Staphylococcus Streptococcus the lungs, yet their roles pathogenesis remain elusive. Here, we report that nepalensis releases corisin, peptide conserved diverse staphylococci, to induce cells. The mice exhibits acute exacerbation after intrapulmonary instillation...
Three novel Shewanella species are described on the basis of phenotypic, chemotaxonomic and phylogenetic studies. A total six halophilic, aerobic organisms with ability to produce eicosapentaenoic acid (EPA) were isolated from various sea animals in Japan. Cells all isolates Gram-negative, rod-shaped motile by means polar flagella. They able large amounts EPA (about 20% fatty acids) had isoprenoid quinones Q-7 Q-8 as major components. Analysis nearly complete 16S rRNA gene sequences showed...
The lipid and fatty acid compositions in nine obligate facultative barophilic bacteria isolated from the intestinal contents of seven deep-sea fish were determined. Phospholipid simple, with phosphatidylethanolamine phosphatidylglycerol predominating all strains. Docosahexaenoic (DHA; 22:6n-3), which has not been reported procaryotes except for bacteria, was found to be present eight strains at a level 8.1 21.5% total acids. In other strain, eicosapentaenoic (EPA; 20:5n-3) 31.5% Other acids...
In fish sauce production, microorganisms are associated with the fermentation process; however, sequential changes in bacterial communities have never been examined throughout period of fermentation. this study, we determined floras a mash over 8 months, using three different culture media and 16S rRNA gene clone library analysis. During first 4 weeks, viable counts non-halophilic halophilic bacteria decreased were dominated by Staphylococcus species. Between 6 highly markedly increased from...
To investigate the relationship between peripheral blood levels of agouti-related protein (AGRP) and various parameters obesity, we measured plasma level AGRP in 15 obese nonobese men evaluated its with body mass index (BMI), fat weight, visceral, sc, total areas by computed tomography, fasting insulin levels, glucose infusion rate during an euglycemic hyperinsulinemic clamp study, serum leptin, alpha-MSH. Obese had significantly higher concentrations than (P < 0.01). Univariate analysis...
OBJECTIVE: It is well known that nitric oxide synthase (NOS) expressed and it modulates glucose transport in skeletal muscles. Recent studies have shown adipose tIssues also express inducible endothelial (eNOS). In the present study, we investigated whether (NO) induces uptake adipocytes, signaling pathway involved NO-stimulated 3T3-L1 adipocytes. METHODS: First, determined expression of eNOS then these cells were treated with NO donor sodium nitroprusside (SNP) and/or insulin,...
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy currently available. A growing body evidence supports the role transforming growth factor (TGF)-β1 as major player in pathogenesis disease. However, attempts to control its expression and improve outcome have been disappointing. We tested hypothesis that TGF-β1 dominant acute phases developed short interfering (si)RNAs directed toward molecules implicated This study novel sequences siRNAs targeting...
There have been very few reported investigations on the standardized incidence ratio (SIR) of intestinal cancer and all cancers other than with Crohn's disease (CD) by organ in Japan. This study examined risk developing (i.e. SIR) that occurs association CD.The subjects were 770 CD patients managed at our hospital department, which specializes inflammatory bowel disease, during approximately 25 years from July 1985 to August 2010. The number expected a healthy population matched for sex age...
The purpose of this study was to clarify the clinicopathological characteristics autoimmune pancreatitis (AIP) in Japanese patients with inflammatory bowel disease (IBD).The findings 7 IBD whose definite AIP diagnosed our hospital according International Consensus Diagnostic Criteria were reviewed.Five (0.5%) 961 ulcerative colitis (UC) and 2 (0.3%) 790 Crohn had AIP. All type 2. rate elevated values serum immunoglobulin G4 0%. Most diagnosis preceded that AIP, activity active. Granulocyte...
Three Gram-negative, non-motile, strictly aerobic strains, designated LNM-20 T , LCM-1 and LAM-13, were isolated from thalli of the marine red alga Porphyra yezoensis . Phylogenetic analysis based on 16S rRNA gene sequences revealed that isolates associated with genus Polaribacter in family Flavobacteriaceae most closely related to dokdonensis DSW-5 (96.2 % sequence similarity) gangjinensis K17-16 (95.0 %). The DNA G+C content was 28.6–29.2 mol%. DNA–DNA hybridization showed belonged a...
Abstract Five bacterial strains isolated from the intestine of deep sea fish were shown to produce docosahexaenoic acid (22∶6n−3; DHA) at a level 6.4 11.6% total fatty acids when incubated in DHA‐free medium. In all examined, other polyunsaturated barely detectable, except for eicosapentaenoic (20∶5n−3). A typical strain, such as T3615, produced DHA concentration about 0.8 mg/L within six days aerobic incubation 5°C and under atmospheric pressure. The T3615 belonging genus Vibrio , is...