A5102876427- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes Management and Research
- Renal Diseases and Glomerulopathies
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dialysis and Renal Disease Management
- Renin-Angiotensin System Studies
- Pharmacology and Obesity Treatment
- Neurological and metabolic disorders
- Aldose Reductase and Taurine
- Clinical practice guidelines implementation
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Peptidase Inhibition and Analysis
- Diet, Metabolism, and Disease
- Heart Failure Treatment and Management
- Neurological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Asahikawa Medical University
2013-2023
University of Oxford
2023
Asahikawa University
2011-2021
Kishokai Medical Corporation
2017-2020
Osaka Nishi Clinic
2019
Shiga University of Medical Science
1997-2016
Kanazawa Medical Center
2016
Asahikawa Medical College Hospital
2005-2015
Bipar
2013
Kanazawa Medical University
2006
Concept of Diabetes Mellitus: mellitus is a group diseases associated with various metabolic disorders, the main feature which chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long-term persistence disorders can cause susceptibility specific complications also foster arteriosclerosis. broad range clinical presentations, from being asymptomatic ketoacidosis or coma, depending on degree disorder. Classification...
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process attenuated by calorie restriction (CR). However, the molecular underlies beneficial effect CR on mitochondrial dysfunction unclear. Here, we investigated in mice mechanisms underlying CR-mediated protection against hypoxia aged kidney, with special focus role NAD-dependent deacetylase sirtuin 1 (Sirt1), which linked to CR-related longevity model organisms, autophagy. Adult-onset...
The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH). Seven both NASH and hypertension were treated losartan (50 mg/d) for 48 weeks. Treatment resulted a significant decrease blood markers hepatic fibrosis, plasma TGF-β1 serum ferritin concentration concurrently an improvement aminotransferase levels. Histological assessment showed necroinflammation five patients, reduction fibrosis four disappearance iron...
Activation of protein kinase C (PKC) is implicated as an important mechanism by which diabetes causes vascular complications. We have recently shown that a PKC β inhibitor ameliorates not only early diabetes-induced glomerular dysfunction such hyperfiltration and albuminuria, but also overexpression mRNA for transforming growth factor β1 (TGF-βΙ) extracellular matrix (ECM) proteins in streptozoto-cin-induced diabetic rats, model type 1 diabetes. In this study, we examined the long-term...
Overcoming refractory massive proteinuria remains a clinical and research issue in diabetic nephropathy. This study was designed to investigate the pathogenesis of nephropathy, with special focus on podocyte autophagy, system intracellular degradation that maintains cell organelle homeostasis, using human tissue samples animal models. Insufficient autophagy observed histologically patients rats diabetes accompanied by loss, but not those no or minimal proteinuria. Podocyte-specific...
Inflammation signaled by Janus kinases (JAKs) promotes progression of diabetic kidney disease (DKD). Baricitinib is an oral, reversible, selective inhibitor JAK1 and JAK2. This study tested the efficacy baricitinib versus placebo on albuminuria in adults with Type 2 diabetes at high risk for progressive DKD.In this Phase 2, double-blind, dose-ranging study, participants were randomized 1:1:1:1:1 to receive or (0.75 mg daily; 0.75 twice 1.5 4 daily), 24 weeks followed 4-8 washout.Participants...
The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an converting enzyme inhibitor (ACEI). We examined the olmesartan, ARB, on primary composite outcome doubling serum creatinine, endstage disease death overt nephropathy. Secondary included outcomes, changes function proteinuria. Randomisation allocation to trial group were carried out by central computer system....
Obesity is an independent risk factor for renal dysfunction in patients with CKDs, including diabetic nephropathy, but the mechanism underlying this connection remains unclear. Autophagy intracellular degradation system that maintains homeostasis by removing damaged proteins and organelles, autophagy insufficiency associated pathogenesis of obesity-related diseases. We therefore examined role obesity-mediated exacerbation proteinuria-induced proximal tubular epithelial cell damage mice human...
Since its inception in 2004, the 'Clinical Practice Guidelines for Treatment of Diabetes' has attempted to promote evidence-based, rational, efficient and standardized clinical practice diabetes Japan undergone revisions every 3 years. Thus, current edition represents fifth revision. Of note, recent years, breakthroughs have been made management complications, which include approval glucose-lowering agents with novel mechanisms action use introduction adoption diagnostic therapeutic...
Numerous reports have demonstrated that oxidative stress induced by diabetes plays an important role in the development and progression of diabetic vascular complications including nephropathy. Indeed, there is emerging evidence formation reactive oxygen species (ROS) a direct consequence hyperglycemia. Biomarkers for damage to DNA, lipids, proteins are also supporting concept increased However, unanswered question: When does as pathogenetic event occur process nephropathy? To answer this...
Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal injury in patients metabolic may be a result altered lipid metabolism. We fed wild-type or insulin-sensitive heterozygous peroxisome proliferator-activated receptor gamma-deficient (PPARgamma(+/-)) mice high-fat diet for 16 weeks. In mice, this induced core features syndrome, subsequent accumulation, including glomerulosclerosis, interstitial fibrosis, albuminuria. Renal lipogenesis accelerated,...
Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) C57BL/6 mice is induce systemic metabolic abnormalities and subsequent renal injuries, such as albuminuria, similar human syndrome, alterations in HFD-induced injuries have not fully elucidated detail. We therefore investigated structural functional changes kidneys on HFD. Six-week-old were fed low-fat (LFD; 10% total calories from...
The activation of protein kinase C (PKC) found in diabetic glomeruli and glomerular mesangial cells cultured under high glucose conditions has been proposed to contribute the development nephropathy. However, abnormalities distal PKC have not fully elucidated yet. Herein, we provide evidence that mitogen-activated (MAPK) cascade, an important cascade downstream activator cytosolic phospholipase A2 (cPLA2) by direct phosphorylation, is activated isolated from streptozotocin-induced rats. MAPK...
SIRT1, a class III histone deacetylase, is considered key regulator of cell survival and apoptosis through its interaction with nuclear proteins. In this study, we have examined the likelihood role between SIRT1 Smad7, which mediates transforming growth factor β (TGFβ)-induced in renal glomerular mesangial cells. Immunoprecipitation analysis revealed that directly interacts N terminus Smad7. Furthermore, reversed acetyl-transferase (p300)-mediated acetylation two lysine residues (Lys-64 -70)...
To date, evidence for long-term renoprotection with angiotensin receptor blockers (ARBs) has come almost exclusively from Caucasian patients (1–3), despite Japanese people being at high risk of diabetic nephropathy and very susceptible to end-stage renal disease (4–6). We conducted the INNOVATION Study (Incipient Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy) evaluate efficacy an ARB in preventing transition microalbuminuria overt (7). This study is...
To estimate the frequency of remission/regression microalbuminuria and to identify factors affecting such outcomes in Japanese patients with type 2 diabetes, we observed 216 diabetes enrolled during an initial 2-year evaluation period for next 6 years. Remission was defined as shift normoalbuminuria regression a 50% reduction urinary albumin excretion rate (AER) from one next. Reduction AER frequent, 6-year cumulative incidence 51% (95% CI 42–60) remission 54% (45–63) regression, whereas...
Oxidative stress is implicated to play an important role in the development of diabetic vascular complications, including nephropathy. It unclear whether oxidative primarily enhanced glomeruli or it merely a consequence diabetes-induced glomerular injury. To address this issue, we examined determine enhanced, as well protein kinase C (PKC)-β activation modulating NADPH oxidase activity. Urinary 8-hydroxydeoxyguanosine excretion and its intense immune-reactive staining were markedly higher...
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are released during meals from endocrine cells located in the gut mucosa stimulate insulin secretion pancreatic beta-cells a glucose-dependent manner. Although epithelium senses luminal sugars, mechanism of sugar sensing its downstream events coupled to release incretin hormones not clearly elucidated. Recently, it was reported that sucralose, sweetener activates sweet receptors taste buds, triggers murine...
Diabetic retinopathy is the leading cause of blindness in Western world (1) and characterized by abnormal angiogenesis driven several factors, including tissue ischemia hyperglycemia. This results new vessels that are often immature play a pathological role retinopathy, contributing to both vitreous hemorrhage fibrosis (2). In addition, increased vascular permeability plasma leakage accounts for development macula edema, disrupting visual function These evidences have led therapeutic...
The Joint Committee on Diabetic Nephropathy has revised its Classification of (Classification 2014) in line with the widespread use key concepts, such as estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). In revising Classification, carefully evaluated, relevant to current revision, report a study conducted by Research Group Nephropathy, Ministry Health, Labor Welfare Japan. Major revisions are summarized follows: (i) eGFR is substituted for GFR Classification;...