A5029747116- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Diabetes Management and Research
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Protein Kinase Regulation and GTPase Signaling
- Cardiovascular Disease and Adiposity
- Health Promotion and Cardiovascular Prevention
- Chronic Disease Management Strategies
- Lipid metabolism and disorders
- Cardiovascular Health and Risk Factors
- Pharmacology and Obesity Treatment
- Obesity and Health Practices
- Epigenetics and DNA Methylation
The University of Tokyo
2016-2025
Diabetes Australia
2010-2024
Japan Agency for Medical Research and Development
2018-2023
University of Oxford
2023
Osaka University
2023
University of Tokyo Hospital
2006-2021
Aso Iizuka Hospital
2019
Juntendo University
2012-2016
Japan Science and Technology Agency
2002-2015
Tokyo Medical University
2004-2006
The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, it reported exhibit putative antiatherogenic properties <i>in vitro</i>. In this study we generated adiponectin-deficient mice directly investigate whether a physiological protective role against diabetes atherosclerosis vivo</i>. Heterozygous (<i>adipo</i> <sup>+/−</sup>) showed mild resistance, while homozygous <sup>−/−</sup>) moderate...
Adiponectin is an adipocyte-derived hormone, which has been shown to play important roles in the regulation of glucose and lipid metabolism. Eight mutations human adiponectin have reported, some were significantly related diabetes hypoadiponectinemia, but molecular mechanisms decreased plasma levels impaired action mutants not clarified. structurally belongs complement 1q family known form a characteristic homomultimer. Herein, we demonstrated that simple SDS-PAGE under non-reducing...
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain (gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. Interestingly, despite an unexpected similar body weight, gAd Tg showed amelioration resistance β-cell degranulation as well diabetes, indicating that leptin appeared have both distinct overlapping functions....
Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles MCP-1 overexpression in adipose, we generated transgenic mice by utilizing adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These had higher plasma increased macrophage accumulation adipose tissues, as confirmed immunochemical, flow cytometric, gene analyses. Tumor necrosis factor-α interleukin-6 mRNA levels white non-esterified fatty...
An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the gene (APM1) located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 (P = 0.003 P 0.002, respectively). Subjects G/G genotype position or had significantly increased risk (odds ratio 1.70 [95% CI 1.09-2.65] 2.16...
Peroxisome proliferator-activated receptor (PPAR) γ is a ligand-activated transcription factor and member of the nuclear hormone superfamily that thought to be master regulator fat storage; however, relationship between PPARγ insulin sensitivity highly controversial. We show here supraphysiological activation by agonist thiazolidinediones (TZD) markedly increases triglyceride (TG) content white adipose tissue (WAT), thereby decreasing TG liver muscle, leading amelioration resistance at...
The high-molecular weight (HMW) form of adiponectin, an adipocyte-derived insulin-sensitizing hormone, has been reported to be the most active this hormone. We investigated whether measurement plasma HMW adiponectin levels, using our newly developed enzyme-linked immunosorbent assay system for selective human level, may useful prediction insulin resistance and metabolic syndrome.A total 298 patients admitted diabetes treatment or coronary angiography served as study subjects. Receiver...
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 -R2 serve receptors for adiponectin mediate increased fatty acid oxidation glucose uptake adiponectin. In the present study, we examined expression levels roles of AdipoR1/R2 in several physiological pathophysiological states such fasting/refeeding, obesity, insulin resistance. Here show target organs, skeletal muscle liver, significantly...
To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. IRS-2-/- showed resistance and defect insulin-stimulated signaling pathway liver but not skeletal muscle. Despite resistance, amount beta-cells was reduced 83% that which marked contrast 85% increase IRS-1-deficient (IRS-1-/-...
We examined the effects of activation peroxisome proliferator–activated receptor (PPAR)α, PPARγ, and both them in combination obese diabetic KKAy mice investigated mechanisms by which they improve insulin sensitivity. PPARα its agonist, Wy-14,643, as well PPARγ rosiglitazone, markedly improved Interestingly, dual -γ a Wy-14,643 rosiglitazone showed increased efficacy. Adipocyte size Wy-14,643–treated was much smaller than that vehicle- or rosiglitazone-treated mice, suggesting prevents...