A5004740539- Antibiotic Resistance in Bacteria
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Enterobacteriaceae and Cronobacter Research
- Growth Hormone and Insulin-like Growth Factors
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Pharmaceutical and Antibiotic Environmental Impacts
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- TGF-β signaling in diseases
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Streptococcal Infections and Treatments
- Ovarian cancer diagnosis and treatment
- Viral gastroenteritis research and epidemiology
- Infections and bacterial resistance
- Kruppel-like factors research
- Biosensors and Analytical Detection
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Pituitary Gland Disorders and Treatments
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
Nara Medical University
2015-2024
Nara Medical University Hospital
2022
Osaka Minami Medical Center
2020
Shandong Academy of Agricultural Sciences
2018
Osaka Ekisaikai Hospital
2018
Teikyo University
2012-2017
Kanagawa Academy of Science and Technology
2011-2016
Shinshu University
2013-2014
Kyushu Hospital
2011-2013
Kitasato University
2003-2012
To investigate the role of insulin receptor substrate (IRS)-2 in vivo, we generated IRS-2-deficient mice by gene targeting. Although homozygous (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. IRS-2-/- showed resistance and defect insulin-stimulated signaling pathway liver but not skeletal muscle. Despite resistance, amount beta-cells was reduced 83% that which marked contrast 85% increase IRS-1-deficient (IRS-1-/-...
Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (CuxO/TiO2) inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) virus, including its Delta variant, even under dark condition, and further it illumination a white fluorescent bulb. To investigate inactivation mechanism, denaturation spike proteins SARS-CoV-2...
To investigate apoptotic changes, we studied the cleavage of DNA in uterine endometrium obtained from regularly cycling women by a quantitative end labeling gel fractionation and situ analysis. The ladder pattern characteristic into fragments low mol wt was identified at three different phases cycle, namely early proliferative, late secretory, menstrual phases. However, high predominant during midsecretory Our analysis revealed that cells undergoing apoptosis were scattered functional layer...
To elucidate the role of apoptotic cell death in human corpus luteum (CL) regression, CL during menstrual cycle and early pregnancy were isolated processed for biochemical (radio-labeling) analysis DNA integrity. Total extracted from luteal phase contained predominantly high mol wt DNA, whereas midluteal exhibited appearance cleavage into low ladders characteristic apoptosis. Although significantly increased to late (P < 0.05), did not exhibit fragmentation by analysis. In situ revealed that...
Photocatalytically active titanium dioxide (TiO2) is widely used as a self-cleaning and self-disinfecting material in many applications to keep environments biologically clean. Several studies on the inactivation of bacteria viruses by photocatalytic reactions have also been reported; however, only few evaluated spectrum microbicidal activity with photocatalysis for various species. There need confirm expected effectiveness disinfection against multidrug-resistant viruses. In this study, was...
The evidence of association between sexually transmitted infection and prostatic inflammation in human prostate cancer (PCa) is limited. Here, we sought to examine the potential with inflammatory environment carcinogenesis. We screened surgical biopsy specimens from 45 patients PCa against a panel infection-related organisms using polymerase chain reaction examined severity intraprostatic by pathologic examination. Among tested organisms, rate Mycoplasma genitalium (Mg) was significantly...
The immunohistochemical localization of the alpha-, beta A-, and B-subunits inhibin was examined in human follicles during follicular growth. Immunoreactive staining with antisera against observed granulosa cells, whereas no for each subunit thecal or interstitial cells. In preantral small antral follicles, cells exhibited positive immunoreactive A- negative immunostaining antiserum alpha-subunit. medium-sized healthy obtained midfollicular phase, detected contrast, not similarly sized...
The family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) is responsible for the altered glycosylation in cancer. purpose our study was to investigate clinical significance two isoforms, GalNAc-T6 and -T3, their correlation with prognosis pancreatic cancer.Immunohistochemistry used analyse -T3 expressions 70 clinicopathologically characterised cancer cases.Positive were immunohistochemically identified 51% (36 70) 77% (54 patients, respectively. A close relationship noted...
The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps mucin-type O-glycosylation. might show novel patterns GalNAc-T glycosylation on tumour-derived proteins, which could influence cancer biology, but its mechanisms are unclear. We investigated association GalNAc-T3 and -T6 expressions with clinicopathological features prognoses patients renal cell carcinomas (RCCs). Expressions GalNAc-T3/6 cell-adhesion molecules were analysed...
This study aimed to evaluate the prevalence and genetic characteristics of carbapenemase-producing Enterobacteriaceae (CPE) in hospital sewage river water Philippines, which has a typical tropical maritime climate. We collected 83 samples from 7 10 sites. CPE were identified using CHROMagar mSuperCARBA, Gram-negative strains matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) or 16S rRNA gene sequencing. Resistance genes PCR DNA sequencing,...
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the world. Inactivating virus in saliva and oral cavity represents a reasonable approach to prevent human-to-human transmission because is easily transmitted through routes dispersed saliva. Persimmon-derived tannin condensed type of that strong antioxidant antimicrobial activity. In this study, we investigated antiviral effects persimmon-derived...
The distribution of the extracellular matrix, including type I, III, IV and VI collagens laminin, prolyl hydroxylase was investigated in human endometrium by an indirect immunofluorescence method with specific monoclonal antibodies. Collagens were also extracted from endometrial tissues proliferative secretory phases decidual first trimester pregnancy. Immunohistochemical studies demonstrated that interstitial collagens, such as localized diffusely stroma throughout menstrual cycle, well...
The maintenance of infectivity influenza viruses on the surfaces personal protective equipment and clothing is an important factor in terms controlling viral cross-infection environment preventing contact infection. aim this study was to determine if laboratory-grown A (H1N1) virus maintained used healthcare settings.Influenza (0.5 mL) deposited surface a rubber glove, N95 particulate respirator, surgical mask made non-woven fabric, gown Dupont Tyvek, coated wooden desk, stainless steel....
Carbapenems serve as a last resort for the clinical treatment of multidrug-resistant infections. Therefore, rapid spread carbapenemase-producing strains represents serious public health threat, further limiting antibiotic choices. The current findings hypervirulent Klebsiella pneumoniae isolates in Japan demonstrate potential broad and transfer these genes, necessitating close surveillance.