A5051700235- Bladder and Urothelial Cancer Treatments
- Sphingolipid Metabolism and Signaling
- Urinary and Genital Oncology Studies
- Anesthesia and Sedative Agents
- Dental Anxiety and Anesthesia Techniques
- Transportation Planning and Optimization
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Diverse Aspects of Tourism Research
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Urban and spatial planning
- Traffic Prediction and Management Techniques
- Colorectal Cancer Screening and Detection
- Caveolin-1 and cellular processes
- Advanced Proteomics Techniques and Applications
- Smart Parking Systems Research
- Endoplasmic Reticulum Stress and Disease
- Airway Management and Intubation Techniques
- Urban and Freight Transport Logistics
- Eicosanoids and Hypertension Pharmacology
- Immune cells in cancer
Cedars-Sinai Medical Center
2019-2025
National Cancer Center Hospital East
2022-2025
University of Hawaii System
2012-2023
Cancer Center of Hawaii
2012-2023
University of Hawaiʻi at Mānoa
2012-2023
University of Hawaii Cancer Center
2012-2023
Toyo University
2008-2022
Medical University of South Carolina
2010-2012
Ralph H. Johnson VA Medical Center
2011
MUSC Hollings Cancer Center
2011
Abstract Neoadjuvant chemotherapy (NAC) prior to surgery and immune checkpoint therapy (ICT) have revolutionized bladder cancer management. However, stratification of patients that would benefit most from these modalities remains a major clinical challenge. Here, we combine single nuclei RNA sequencing with spatial transcriptomics single-cell resolution proteomic analysis human identify an epithelial subpopulation therapeutic response prediction ability. These cells express Cadherin 12 (...
Current knowledge of the molecular mechanism driving tumor budding is limited. Here, we focused on elucidating detailed underlying in urothelial cancer bladder. Invasive was pathologically classified into three groups as follows: nodular, trabecular, and infiltrative (tumor budding). Pathohistological analysis orthotopic model revealed that human cell lines MGH-U3, UM-UC-14, UM-UC-3 displayed typical patterns, respectively. Based results comprehensive gene expression using microarray (25 K...
Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1-phosphate, have been linked to colon cancer, suggesting that enzymes of metabolism may emerge as novel regulators targets cancer. Neutral ceramidase (nCDase), a key enzyme hydrolyzes into sphingosine, is highly expressed the intestine; however, its role cancer has not defined. Here we show molecular pharmacological inhibition nCDase cells increases ceramide, this accompanied by decreased cell survival increased...
The evidence of association between sexually transmitted infection and prostatic inflammation in human prostate cancer (PCa) is limited. Here, we sought to examine the potential with inflammatory environment carcinogenesis. We screened surgical biopsy specimens from 45 patients PCa against a panel infection-related organisms using polymerase chain reaction examined severity intraprostatic by pathologic examination. Among tested organisms, rate Mycoplasma genitalium (Mg) was significantly...
Abstract Chemoimmunotherapy has recently failed to demonstrate significant clinical benefit in advanced bladder cancer patients; and the mechanism(s) underlying such suboptimal response remain elusive. To date, most studies have focused on tumor-intrinsic properties that render them “immune-excluded”. Here, we explore an alternative, drug-induced mechanism impedes therapeutic via disrupting onset of immunogenic cell death. Using two immune-excluded syngeneic mouse models muscle-invasive...
It is important to identify novel and effective targets for cancer prevention therapy against head neck squamous cell carcinoma (HNSCC), one of the most lethal cancers. Accumulating evidence suggests that bioactive sphingolipids, such as sphingosine-1-phosphate (S1P) its generating enzyme, sphingosine kinase 1 (SphK1) play pivotal roles in several biological functions including promoting tumor growth carcinogenesis. However, SphK1/S1P HNSCC development and/or progression have not been...
Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification multiplex molecular signatures associated disease has potential address this deficiency and assist accurate, non-invasive diagnosis monitoring.To evaluate performance Oncuria™, immunoassay for detection voided urine samples. test was evaluated multi-institutional cohort 362 prospectively collected subjects presenting cancer evaluation. parallel...
8509 Background: Neoadjuvant treatments for resectable non-small cell lung cancer (NSCLC) using novel combination therapies are being developed. Angiogenesis inhibitors have been reported to modify tumor immunity, and the efficacy safety of added immune checkpoint (ICIs) investigated in advanced NSCLC. In this multi-institutional phase II study, we evaluated feasibility neoadjuvant therapy with pembrolizumab ramucirumab, a direct vascular endothelial growth factor (VEGF) receptor-2...
Background/Objectives: Urinalysis accuracy requires reliable sample stability that is dependent on the chosen collection and storage conditions. The multiplex Oncuria bladder cancer immunoassay currently needs urine samples stored at 4 °C until analysis, which more effort, equipment, workflow than storing room temperature. Thus, successful temperature (20 °C) may reduce laboratory handling time expenses. This study evaluated whether different voided parameters affected subsequent biomarker...
TPS504 Background: Zolbetuximab, a monoclonal antibody targeting CLDN18.2, was recently approved in Japan for patients with HER2-negative/CLDN18.2-positive metastatic gastric or gastroesophageal junction cancer (mGC/GEJC). On-target GI toxicities such as nausea and vomiting are commonly observed during first infusion, occasionally leading to early treatment discontinuation. Effective management of these is essential the successful use zolbetuximab clinical practice. This study aims assess...
To validate the expression of a urine-based bladder cancer associated diagnostic signature comprised 10 targets; ANG, CA9, MMP9, MMP10, SERPINA1, APOE, SDC1, VEGFA, SERPINE1 and IL8 in tumor tissues.Immunohistochemical analyses were performed on specimens from 213 patients (transitional cell carcinoma only) 74 controls. Staining patterns digitally captured quantitated (Aperio, Vista, CA), was correlated with stage, grade outcome measures.We revealed positive association 9 proteins (excluding...
Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was develop a multiplex immunoassay accurately simultaneously monitor ten diagnostic urinary protein biomarkers for application as non-invasive test BCa detection. A custom electrochemiluminescent assay constructed (Meso Scale Diagnostics, LLC, Rockville, MD, USA) following proteins; IL8, MMP9, MMP10, ANG, APOE, SDC1, A1AT, PAI1,...
Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) a divalent ion channel involved cellular systemic Mg2+ homeostasis. Abnormal expression of TRPM7 found numerous cancers, including colon, implicating this process. To establish possible link between magnesium status, the conducting colon epithelial cells, vitro whole-cell patch clamp electrophysiology, qPCR,...
Rationale:The expression of the chemokine (C-X-C motif) ligand 1 (CXCL1), an inflammatory protein, has been reported to be up-regulated in many human cancers.The mechanisms through which aberrant cellular CXCL1 levels promote specific steps tumor growth and progression are unknown.Methods: We described anticancer effects mechanism action HL2401, a monoclonal antibody directed at with vitro vivo data on bladder prostate cancers.Results: HL2401 inhibited proliferation invasion cells along...
Combining an immune checkpoint inhibitor with a tumor vaccine may modulate the system to leverage complementary mechanisms of action that lead sustained T-cell activation and potent prolonged immunotherapeutic response in metastatic castration resistant prostate cancer (mCRPC).Subjects asymptomatic or minimally symptomatic mCRPC were randomly assigned 1:1 ratio receive either atezolizumab followed by sipuleucel-T (Arm 1) 2). The primary endpoint was safety, while secondary endpoints included...
Abstract Background No single marker of bladder cancer (BC) exists in urine samples with sufficient accuracy for disease diagnosis and treatment monitoring. The multiplex Oncuria BC assay noninvasively quantifies the concentration 10 protein analytes voided to quickly generate a unique molecular profile proven diagnostic treatment-tracking utility. Test adoption by research laboratories mandates reliably reproducible performance across variety instrumentation platforms used different...
// David Paladino 1, 2 , Peibin Yue Hideki Furuya 3 Jared Acoba Charles J. Rosser James Turkson 1 Natural Products and Experimental Therapeutics Program, University of Hawaii Cancer Center, Hawaii, Manoa, Honolulu, HI 96813, USA Biology Clinical Translational Research Correspondence to: Turkson, e-mail: jturkson@cc.hawaii.edu Keywords: Src, p300, pancreatic cancer, migration, invasion Received: November 12, 2015 Accepted: 23, Published: December 17, ABSTRACT The presence Src in the nuclear...
The early detection of gastric neoplasms (GNs) leads to favorable treatment outcomes. latest endoscopic system, EVIS X1, includes third-generation narrow-band imaging (3G-NBI), texture and color enhancement (TXI), high-definition white-light (WLI). Therefore, this randomized phase II trial aimed identify the most promising modality for GN using 3G-NBI TXI.
Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive loco-regional invasion. Sphingosine kinase1 (SphK1), an enzyme in sphingolipid metabolism, emerging as a key player HNSCC pathology. The observation that SphK1 overexpressed all stages associated with depth of tumor invasion, metastasis clinical failure underscores the importance Still, mechanisms underlying regulation invasion have not been delineated. Therefore, we sought to mechanistically describe how regulates...
Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate an extremely low survival rate. There is limited availability of effective therapies to reduce the recurrence, resulting in morbidity mortality advanced cases. Late presentation, delay detection lesions, metastasis make HNSCC devastating disease. This review offers insight into role sphingosine kinase-1 (SphK1), key enzyme sphingolipid metabolism, HNSCC. Sphingolipids not only play structural cellular membranes, but...
Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due high rate of post-operative disease recurrence, it one prevalent in many countries. The development non-invasive molecular assays that can accurately detect monitor BCa would be a major advance, benefiting both patients healthcare systems. We have previously identified urinary protein biomarker panel being developed for application at-risk patient cohorts. Here, we investigated potential utility...