A5069682012- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
- Myasthenia Gravis and Thymoma
- Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Congenital Diaphragmatic Hernia Studies
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Pneumothorax, Barotrauma, Emphysema
- Trauma Management and Diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
National Cancer Center Hospital East
2021-2025
Fukuoka Higashi Medical Center
2023
Kanagawa Cancer Center
2017-2021
Kanagawa Prefectural Hospital Organization
2017-2021
Japanese Foundation For Cancer Research
2015-2019
Yokohama City University
2007-2017
Kanazawa University
2017
The Cancer Institute Hospital
2015-2016
Kanagawa Cardiovascular and Respiratory Center
2010-2014
International University Of Health And Welfare Atami Hospital
2009
8509 Background: Neoadjuvant treatments for resectable non-small cell lung cancer (NSCLC) using novel combination therapies are being developed. Angiogenesis inhibitors have been reported to modify tumor immunity, and the efficacy safety of added immune checkpoint (ICIs) investigated in advanced NSCLC. In this multi-institutional phase II study, we evaluated feasibility neoadjuvant therapy with pembrolizumab ramucirumab, a direct vascular endothelial growth factor (VEGF) receptor-2...
This is a preliminary analysis of one the secondary endpoints in prospective study cohort. The aim this to assess image quality and diagnostic confidence for lung cancer CT images generated by using cadmium-zinc-telluride (CZT)-based photon-counting-detector-CT (PCD-CT) comparing these super-high-resolution (SHR) with conventional normal-resolution (NR) images. Twenty-five patients (median age 75 years, interquartile range 66-78 18 men 7 women) 29 nodules overall (including two 4 2 nodules,...
Abstract Background The JCOG0804/WJOG4507L single-arm confirmatory trial indicated a satisfactory 10-year prognosis for patients who underwent limited resection radiologically less-invasive lung cancer. However, only one prospective has reported prognosis. Methods We conducted multicenter study coordinated by the National Cancer Center Hospital East and Kanagawa Center. analyzed long-term of 100 cancer in peripheral field. defined as adenocarcinoma with maximum tumor diameter ≤2 cm,...
Background Surgical lung biopsy is generally considered the most appropriate method for diagnosing diffuse disease. However, there are few reports focusing on only one thoracoscopic technique. This study was designed to determine morbidity and mortality related video-assisted in a single center, thereby providing data severity of clarifying risk factors. Methods We analyzed 285 patients with undiagnosed disease who underwent at Kanagawa Cardiovascular Respiratory Center from February 2007...
Abstract Background We quantified the pathological spatial intratumor heterogeneity of programmed death-ligand 1 (PD-L1) expression and investigated its relevance to patient outcomes in surgically resected non–small cell lung carcinoma (NSCLC). Methods This study enrolled 239 consecutive NSCLC specimens stage IIA-IIIB. To characterize PD-L1 tissues, we developed a mathematical model based on texture image analysis determined index for each tumor. The correlation between values...
Abstract Background The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification neoplasms pancreas. Pancreatic NET G3 shows a carcinoid-like morphology with high proliferative activity and prognosis is intermediate between G2 carcinoma. There no corresponding to current WHO 2015 lung tumors. Herein, we report two cases carcinoma carcinoid that correspond G3. Case presentation 1: An abnormal chest shadow detected...
The Oncomine Dx Target Test (ODxTT) is a next-generation sequencing-based companion diagnostic test which has been recently developed; however, its analysis success rate could be improved, especially for small samples. aim of this study was to identify the pathological factors associated with biopsy specimens that affect ODxTT.We retrospectively investigated 119 cases subjected ODxTT at Kanagawa Cancer Center. Data pertaining results BRAF V600E mutation in and based on microscope slides were...
Abstract OBJECTIVES The number of examined mediastinal lymph nodes (mLNs) could represent the quality lymphadenectomy for non-small cell lung cancer (NSCLC). This study aimed to evaluate prognostic impact individual mLNs in patients with resectable NSCLC. METHODS We retrospectively evaluated 1420 clinical stage IA–IIB, N0 NSCLC who underwent complete resection by lobectomy, which involved hilar and mLN dissection, between 2008 2016. investigated threshold that had significance their effects...
Background: Dealing with incomplete lung fissures during thoracoscopic surgery is difficult. Our objective was to evaluate the efficacy and safety of a anterior ‘fissure first’ technique for dealing left fissures. Methods: One hundred seventy patients underwent upper lobectomy or lower between April 2008 July 2014. Of these, 34 using (group A) 136 conventional method unfused B). A four-port complete approach used in all patients. After completion fissure, hilar lymphadenectomy performed...
Angiogenesis inhibitors are known to modify tumor immunity. Combination of angiogenesis with immune checkpoint (ICIs) has shown efficacy against many types cancers, including non-small cell lung cancer (NSCLC). We investigated the feasibility neoadjuvant therapy pembrolizumab and ramucirumab, a vascular endothelial growth factor (VEGF) receptor-2 antagonist for patients PD-L1-positive NSCLC its influence on microenvironment (TME).
Bronchopleural fistula (BPF) remains a serious complication after surgery for lung cancer with bronchial resection. A free pericardial fat pad (FPFP) is applied in high-risk cases to reduce BPF frequency. may occur 6 months surgery. Thus, we evaluated the residual FPFP volume at estimate ratio and determine amount of be harvested during surgery.We retrospectively investigated 40 patients who underwent lobectomy stump coverage using FPFP. During surgery, was measured affixed stump. Further,...
Positron emission tomography is a useful technique for diagnosing lymph node (LN) metastasis. This study aimed to elucidate the association between fluorodeoxyglucose accumulation and microenvironment in metastatic LNs lung adenocarcinoma. We retrospectively analyzed 62 patients with surgically resected pathological N2 adenocarcinoma who underwent preoperative PET. The maximum standardized uptake value (SUVmax ) was measured. Lymph specimens were immunohistochemically CD8+ , FoxP3+ CD79a+...
Dirty necrosis (DN) is a form of tumor (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize clinicopathological features DN metastatic lung cancers colon rectum (MLCRs). A total 227 patients who underwent pulmonary metastasectomy complete resection for MLCR were included this study. TN was evaluated using digitally scanned specimens. These slides immunostained biomarkers NETosis (citrullinated histone H3 [citH3] myeloperoxidase...