A5049613195- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Gene expression and cancer classification
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Cancer Research and Treatments
The University of Tokyo
2016-2025
National Cancer Center Hospital East
2024-2025
Tokyo Medical and Dental University
2013-2024
National Cancer Center
2023-2024
Teikyo University
2024
University of Tokyo Hospital
2023
Chiba Cancer Center
2023
Kansai University
2019
Graduate School USA
2011
Jichi Medical University
2011
Abstract CpG island promoter methylation of tumor suppressor genes is one the most characteristic abnormalities in EBV-associated gastric carcinoma (GC). Aberrant and expression loss PTEN were evaluated cancer tissues GC by methylation-specific PCR immunohistochemistry, respectively, showing that both occurred concurrently GC. reiterated cell lines MKN-1 MKN-7 infected with recombinant EBV, DNA methyltransferase 1 (DNMT1) was commonly overexpressed lines. Stable transient transfection...
Abstract Purpose: Squamous cell carcinoma (SCC) and adenocarcinoma of the lung are currently subject to similar treatment regimens despite distinct differences in histology epidemiology. The aim this study is identify a molecular target with diagnostic therapeutic values for SCC. Experimental Design: Genes specifically up-regulated SCC were explored through microarray analysis 5 SCCs, adenocarcinomas, 10 small carcinomas, 27 normal tissues, 40 cancer lines. Clinical usefulness these genes...
Oatp14/blood-brain barrier-specific anion transporter 1 (Slc21a14) is a novel member of the organic transporting polypeptide (Oatp/OATP) family. Northern blot analysis revealed predominant expression Oatp14 in brain, and Western its brain capillary choroid plexus. Immunohistochemical staining indicated that expressed border endothelial cells. When human embryonic kidney 293 cells, transports thyroxine (T4; prothyroid hormone) (Km = 0.18 μm), as well amphipathic anions such 17β...
Abstract The Glypican (GPC) family is a prototypical member of the cell‐surface heparan sulfate proteoglycans (HSPGs). HSPGs have been demonstrated to interact with growth factors, act as coreceptors and modulate factor activity. Here we show that based on oligonucleotide array analysis, GPC3 was upregulated in hepatocellular carcinoma (HCC). By northern blot mRNA found be 29 52 cases HCC (55.7%). Western analysis carried out monoclonal anti‐GPC3 antibody generated, protein overexpressed 6...
Recent reports indicate that copy number variations (CNVs) within the human genome contribute to nucleotide diversity a larger extent than single polymorphisms (SNPs). In addition, contribution of CNVs disease susceptibility may be greater previously expected, although complete understanding phenotypic consequences is incomplete. We have recently reported comprehensive view among 270 HapMap samples using high-density SNP genotyping arrays and BAC array CGH. this report, we describe novel...
Interstitial cystitis (IC) is a chronic bladder disease with urinary frequency, discomfort or pain of unknown etiology. Based on cystoscopic findings, patients IC are classified as either Hunner-type/classic (HIC), presenting specific Hunner lesion, non-Hunner-type (NHIC), no but post-hydrodistension mucosal bleeding. Inflammatory cell infiltration, composed predominantly lymphocytes, plasma cells and epithelial denudation, has in the past been documented major pathological finding. However,...
BRG 1 and BRM , two core catalytic subunits in SWI / SNF chromatin remodeling complexes, have been suggested as tumor suppressors, yet their roles carcinogenesis are unclear. Here, we present evidence that loss of is involved the progression lung adenocarcinomas. Analysis 15 cancer cell lines indicated mutations correlated with expression was frequent E ‐cadherin‐low vimentin‐high lines. Immunohistochemical analysis 93 primary adenocarcinomas showed 11 (12%) 16 (17%) cases, respectively....
YAP 1 , the main Hippo pathway effector, is a potent oncogene and overexpressed in non‐small‐cell lung cancer ( NSCLC ); however, expression pattern small‐cell SCLC ) has not yet been elucidated detail. We report that loss of special feature high‐grade neuroendocrine tumors. A hierarchical cluster analysis 15 tumor cell lines containing 14 depended on genes molecules markers clearly classified these into two groups: ‐negative marker‐positive group n = 11), ‐positive marker‐negative 4). Among...
Pancreatic ductal neoplasms exhibit gastric epithelium–like characteristics. In this study, we evaluated the expression of claudin-18 (CLDN18), a epithelium–associated claudin, in pancreatic intraepithelial neoplasias (PanINs), intraductal papillary mucinous (IPMNs), cystic (MCNs), and adenocarcinomas (PDACs) using immunohistochemistry. We observed high level CLDN18 PanINs (31/32, 97%), IPMNs (61/65, 95%), MCNs (4/5, 80%) ordinary tissue section analysis. Furthermore, PDACs (109/156, 70%)...
Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells mutations promotes development of T follicular helper (TFH)-like tumor cells. Here, we investigated mechanism which TET2-mutant immune enable AITL using mouse models and human samples. Among 2 models, mice lacking Tet2 all blood (Mx-Cre × Tet2flox/flox transgenic mice) spontaneously developed for approximately up...
The stomach is an important digestive organ with various biological functions. However, because of the complexity its cellular and glandular composition, precise biology has yet to be elucidated. In this study, we conducted single-cell RNA sequencing (scRNA-seq) subcellular-level spatial transcriptomics analysis human constructed largest dataset date: a encyclopedia. This consists approximately 380,000 cells from scRNA-seq transcriptome, enabling integrated analyses transcriptional...
Abstract Small-cell lung cancer (SCLC) is an aggressive for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers are promising therapeutic alternatives ICI-resistant tumors, but not all patients with SCLC responsive. Herein, to integrate CD137 costimulatory function into a engager format and thereby augment efficacy, we generated CD3/CD137 dual-specific Fab engineered DLL3-targeted trispecific antibody (DLL3 trispecific). The was competitively...