A5101744623- Helicobacter pylori-related gastroenterology studies
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Galectins and Cancer Biology
- RNA Research and Splicing
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Proteoglycans and glycosaminoglycans research
- Molecular Biology Techniques and Applications
- Hedgehog Signaling Pathway Studies
- AI in cancer detection
- Genetic factors in colorectal cancer
- Plant Surface Properties and Treatments
- Eosinophilic Esophagitis
- Pluripotent Stem Cells Research
- Cancer Genomics and Diagnostics
Juntendo University
2023-2024
The University of Tokyo
2016-2023
Abstract Evolutionally conserved Wnt, Hedgehog (Hh) and Notch morphogen pathways play essential roles in the development, homeostasis pathogenesis of multicellular organisms. Nevertheless, mechanisms that intracellularly coordinate these signal inputs remain poorly understood. Here we found parafibromin, a component PAF complex, competitively interacts with β-catenin Gli1, thereby potentiating transactivation Wnt- Hh-target genes mutually exclusive manner. Parafibromin also binds to...
YAP and TAZ, the Hippo signal-regulated transcriptional co-activators, play crucial roles in morphogenesis organogenesis. Here we report that YAP/TAZ activities are stimulated upon complex formation with Parafibromin, which undergoes tyrosine phosphorylation dephosphorylation by kinases such as PTK6 phosphatases SHP2, respectively. Furthermore, TAZ Wnt effector β-catenin interact cooperatively tyrosine-dephosphorylated synergistically stimulates co-activator functions of β-catenin. On other...
Helicobacter pylori strains that deliver the oncoprotein CagA into gastric epithelial cells are major etiologic agents of upper diseases including cancer. promotes carcinogenesis through interactions with multiple host proteins. Here, we show also disrupts Wnt-dependent planar cell polarity (Wnt/PCP), which orients within plane an epithelium and coordinates collective behaviors such as convergent extension to enable elongation during development. Ectopic expression in Xenopus laevis embryos...
Here, we summarize the literature relevant to recent advances in three-dimensional (3D) histopathology relation clinical oncology, highlighting serial sectioning, tissue clearing, light-sheet microscopy, and digital image analysis with artificial intelligence. We look forward a future where 3D expands our understanding of human pathophysiology improves patient care through cross-disciplinary collaboration innovation.
In addition to acting as a transcriptional co-activator, YAP1 directly mediates translocalization of the pro-oncogenic phosphatase SHP2 from cytoplasm nucleus. cytoplasm, potentiates RAS–ERK signaling, which promotes cell proliferation and motility, whereas in nucleus, it gene regulation. As result, elucidating details trafficking is important for understanding its biological roles, including cancer. comprises multiple splicing isoforms defined part by presence (as YAP1-2γ) or absence...
Brk/Ptk6, Srms, and Frk constitute a Src-related but distinct family of tyrosine kinases called Brk (BFKs) in higher vertebrates. To date, however, their biological roles have remained largely unknown. In this study, we generated BFK triple-knockout (BFK/TKO) mice lacking all members using CRISPR/Cas9-mediated genome editing. BFK/TKO exhibited impaired intestinal homeostasis, represented by reduced stem/progenitor cell population defective recovery from radiation-induced severe mucosal...