A5062329552- Hippo pathway signaling and YAP/TAZ
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Plant Surface Properties and Treatments
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Helicobacter pylori-related gastroenterology studies
The University of Tokyo
2017-2020
Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the CagA-specific EPIYA-D segment binds to N-SH2 domain of pro-oncogenic SHP2 phosphatase two orders magnitude greater EPIYA-C. This high-affinity binding achieved via cryptic interaction between Phe at +5 position from phosphotyrosine in and a hollow on phosphopeptide-binding floor. Also, duplication EPIYA-C CagA, which increases risk,...
YAP and TAZ, the Hippo signal-regulated transcriptional co-activators, play crucial roles in morphogenesis organogenesis. Here we report that YAP/TAZ activities are stimulated upon complex formation with Parafibromin, which undergoes tyrosine phosphorylation dephosphorylation by kinases such as PTK6 phosphatases SHP2, respectively. Furthermore, TAZ Wnt effector β-catenin interact cooperatively tyrosine-dephosphorylated synergistically stimulates co-activator functions of β-catenin. On other...
In addition to acting as a transcriptional co-activator, YAP1 directly mediates translocalization of the pro-oncogenic phosphatase SHP2 from cytoplasm nucleus. cytoplasm, potentiates RAS–ERK signaling, which promotes cell proliferation and motility, whereas in nucleus, it gene regulation. As result, elucidating details trafficking is important for understanding its biological roles, including cancer. comprises multiple splicing isoforms defined part by presence (as YAP1-2γ) or absence...