A5091124184- Plant Reproductive Biology
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Pregnancy and preeclampsia studies
- Plant Molecular Biology Research
- Birth, Development, and Health
- MicroRNA in disease regulation
- Plant biochemistry and biosynthesis
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Vitamin C and Antioxidants Research
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Electromagnetic Fields and Biological Effects
- Spaceflight effects on biology
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- Polysaccharides and Plant Cell Walls
- Vitamin D Research Studies
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Circadian rhythm and melatonin
- Autophagy in Disease and Therapy
Children's Hospital of Zhejiang University
2021-2025
Liaoning Shihua University
2025
Jinzhou Medical University
2025
Tianjin Medical University
2019-2024
Zhejiang University
2012-2024
Nanjing Agricultural University
2017-2024
Institute of Hematology & Blood Diseases Hospital
2022-2024
Hunan Normal University
2020-2024
Xi'an Technological University
2024
Theranostics (New Zealand)
2022-2024
S-RNase is the female determinant of self-incompatibility (SI) in pear (Pyrus bretschneideri). After translocation to pollen tube, degrades rRNA and induces tube death an S-haplotype-specific manner. In this study, we found that actin cytoskeleton a target P. bretschneideri (PbrS-RNase) uncovered mechanism involves phosphatidic acid (PA) protects from PbrS-RNase cytotoxicity. interacts directly with PbrActin1 S-haplotype-independent manner, causing depolymerize promoting programmed cell...
Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the CagA-specific EPIYA-D segment binds to N-SH2 domain of pro-oncogenic SHP2 phosphatase two orders magnitude greater EPIYA-C. This high-affinity binding achieved via cryptic interaction between Phe at +5 position from phosphotyrosine in and a hollow on phosphopeptide-binding floor. Also, duplication EPIYA-C CagA, which increases risk,...
Abstract Evolutionally conserved Wnt, Hedgehog (Hh) and Notch morphogen pathways play essential roles in the development, homeostasis pathogenesis of multicellular organisms. Nevertheless, mechanisms that intracellularly coordinate these signal inputs remain poorly understood. Here we found parafibromin, a component PAF complex, competitively interacts with β-catenin Gli1, thereby potentiating transactivation Wnt- Hh-target genes mutually exclusive manner. Parafibromin also binds to...
Objective: Calcium dobesilate (CaD), an effective drug for the treatment of diabetic microvascular complications, especially retinopathy, is widely used in clinic. Interestingly, several studies have indicated that CaD therapeutic kidney disease (DKD). Recently, evidence has altered VEGF expression and decreased autophagy are main pathological mechanism proteinuria. Thus, this study was conducted to explore effect on restoring DKD possible signaling pathway between autophagy. Methods: Obese...
Abstract The altered homeostasis of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) was closely associated with the pathological process nervous system diseases and insulin resistance. Here, exact implication phosphofurin acidic cluster sorting protein 2 (PCAS-2), an anchor in MAM interface, diabetic kidney disease investigated. In kidneys type 1 diabetes mice HG-induced HK-2 cells, a notable disruption ER-mitochondria interactions, accompanied by decreased PACS-2...
Because of their extremely broad spectrum and strong biocidal power, nanoparticles metals, especially silver (AgNPs), have been widely applied as effective antimicrobial agents against bacteria, fungi, so on. However, the mutagenic effects AgNPs resistance mechanisms target cells remain controversial.
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes development of diabetes and its complications, but also aggravates occurrence senescence. Previous studies have shown that DR associated with senescence, specific mechanism has been fully elucidated. Here, we first detected differentially expressed genes (DEGs) cellular senescence level db/db mouse retinas by bulk RNA sequencing. Then, used single-cell sequencing...
Abstract As the fifth most common cancer in world, gastric (GC) ranks as third major cause of cancer-related death globally. Although surgical resection and chemotherapy still remains mainstay potentially curative treatment for GC, resistance adverse side effects limit their clinical applications. Thus, further investigation mechanisms carcinogenesis GC discovery novel biomarkers is great concern. We herein report that elevated expression GPR137 correlated with GC. Overexpression potentiates...
Genes encoding subunits of SWI/SNF (BAF) chromatin‑remodeling complexes are recurrently mutated in a broad array tumor types, and among the subunits, ARID1A is most frequent target with mutations. In present study, it was reported that inhibits epithelial‑mesenchymal transition (EMT) stemness ovarian cancer cells, accompanied by reduced cell viability, migration colony formation, suggesting acts as suppressor cancer. Mechanistically, exerts its inhibitory effects on cells activating Hippo...
Ultraviolet‐C (UV‐C), as a physical preservation technology, has the advantages of energy saving, safety, and sanitation broad application prospects in fruit storage. In this study, peach cultivated “Xiahui 5” was used material to investigate impact UV‐C on softening, senescence, postharvest quality peaches. It discovered that postponed peak respiration, retarded loss firmness, inhibited ethylene biosynthesis during The treatment led inhibition growth soluble pectin content reduction...
Background Intracerebral hemorrhage (ICH), a severe subtype of hemorrhagic stroke, is associated with significant disability and high mortality rates. Due to population aging the prevalence hypertension in Asian region, intracerebral has become one major causes mortality. This study analyzes epidemiological patterns ICH across Asia from 1990 2021 projects potential trends for period 2022 2041. Methods extracted four key indicators related (ICH) The Global Burden Disease (GBD) database years...
Three novel compounds, 4-methyl-candidusin A (1), aspetritone (2) and B (3), were obtained from the culture of a coral-derived fungus Aspergillus tritici SP2-8-1, together with fifteen known compounds (4-18). Their structures, including absolute configurations, assigned based on NMR, MS, time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 2 5 exhibited better activities against methicillin-resistant strains S. aureus (MRSA) ATCC 43300 MRSA CGMCC 1.12409 than...