A5051063943- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Tracheal and airway disorders
- Hedgehog Signaling Pathway Studies
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Use and Resistance
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Congenital Ear and Nasal Anomalies
- Head and Neck Anomalies
- Protein Tyrosine Phosphatases
- Ethics and Legal Issues in Pediatric Healthcare
- Tumors and Oncological Cases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Respiratory and Cough-Related Research
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
Children's Hospital of Zhejiang University
2015-2024
Great Ormond Street Hospital
2024
University College London
2024
Zhejiang University
2015-2023
Hunan Agricultural University
2023
Children's Hospital of Fudan University
2023
Weatherford College
2021
Shangqiu First People's Hospital
2021
The First People's Hospital of Wenling
2017
National Medical Products Administration
2017
Improving the quality of hospital antibiotic use is a major goal WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed present data on patterns paediatric AWaRe be used for local national interventions.1-day point prevalence survey prescription were combined from two independent networks: Global Antimicrobial...
Abstract Objectives In this study, we describe the patterns of antibiotic prescription for neonates based on World Health Organization’s (WHO) Essential Medicines List Access, Watch, and Reserve (AWaRe), Management Antibiotic Classification (MAC) Guidelines in China. Methods One-day point-prevalence surveys (PPS) antimicrobial prescriptions were conducted behalf hospitalized China from September 1 November 30, annually 2017 to 2019. Results Data was collected a total 2674 neonatal patients...
The coronavirus disease 2019 (COVID-19) has caused a global pandemic. All people including children are generally susceptible to COVID-19, but the condition is relatively mild for children. diagnosis of COVID-19 largely based on epidemiological evidence and clinical manifestations, confirmed by positive detection virus nucleic acid in respiratory samples. main symptoms fever cough; total number white blood cell count usually normal or decreased; chest imaging characterized interstitial...
We have previously demonstrated that upregulation of Sonic hedgehog (SHH) expression in allergic airway epithelia essentially contributes to the goblet cell metaplasia and mucous hypersecretion. However, mechanism underlying SHH remains completely unknown. In cultured human epithelial cells, IL-4/IL-13 but not IL-5 robustly induces mRNA protein turn activates signaling by promoting JAK/STAT6-controlling transcription gene. Moreover, intratracheal instillation IL-4 and/or IL-13 STAT6...
Deep eutectic solvent (DES) and hot-water extraction (HWE) methods were utilized to extract polysaccharides from Polygonatum sibiricum, referred as DPsP WPsP, respectively. The extracted purified using the Superdex-200 dextran gel purification system, resulting in three components for each type of polysaccharide. structures these characterized. molecular weight analysis revealed that had slightly larger weights compared with DPsP-A showing a higher dispersity index broader distribution. main...
Abstract Sonic hedgehog (Shh) functions as a conserved morphogen in the development of various organs metazoans ranging from Drosophila to humans. Here, we have investigated potential roles and underlying mechanisms Shh signaling murine placentation. Immunostaining revealed abundant expression main components pathway both trophectoderm blastocysts developing placentas. Disruption led impaired vascularogenesis yolk sac, less branching malformation placental labyrinth, thereby leading robust...
Circular RNAs (circRNAs) play potentially important roles in various human diseases; however, their the goblet cell metaplasia of asthma remain unknown.We sought to investigate potential role and underlying mechanism circZNF652 regulation allergic airway epithelial remodeling.The differential expression profiles circRNAs were analyzed by transcriptome microarray, effects mechanisms circZNF652-mediated investigated quantitative real-time PCR, RNA fluorescence situ hybridization, Western blot,...
Abstract Allergic asthma is characterized by goblet cell metaplasia and subsequent mucus hypersecretion that contribute to the morbidity mortality of this disease. Here, we explore potential role underlying mechanism protein SUMOylation-mediated metaplasia. The components SUMOylaion machinery are specifically expressed in healthy human bronchial epithelia robustly upregulated patients or mouse models with allergic asthma. Intratracheal suppression SUMOylation 2-D08 attenuates not only...
Src homology domain 2-containing protein tyrosine phosphatase 2 (SHP2) participates in multiple cell functions including shape, movement, and differentiation. Therefore, we investigated the potential role of SHP2 eosinophil recruitment into lungs allergic airway inflammation explored underlying mechanism. Both Ras homolog family member A (RhoA) kinase were robustly activated eosinophils children with asthma a mouse model inflammation. Moreover, inhibition activity by its specific inhibitors...
Abstract Background Plastic bronchitis (PB) is a clinical‐pathological syndrome characterized by the abnormal accumulation of endogenous substances in bronchial airways, causing partial or complete obstruction and resulting impaired lung ventilation. Methods In this retrospective analysis, we aim to summarize clinical manifestations, imaging characteristics, diagnostic methods, treatment approaches enhance clinicians' ability detect children who are infected with human bocavirus 1 (hBoV 1)...
Use of Broad-spectrum antibiotics is related closely to increasing antimicrobial resistance. Reports on antibiotic prescriptions for Chinese children were rare. We described the prescribing patterns from 2017 2019 based Anatomical Therapeutic Chemical Classification (ATC classification); Access, Watch, and Reserve (AWaRe) classification World Health Organization (WHO), Management Antibiotic in China.A 1-day point-prevalence survey (PPSs) was conducted hospitalized 17 centers 10 provinces 1...