A5100370614- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Blood disorders and treatments
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Optical Imaging and Spectroscopy Techniques
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Autophagy in Disease and Therapy
China Medical University
2017-2025
Suzhou Institute of Biomedical Engineering and Technology
2023-2025
Chinese Academy of Sciences
2023-2025
Tianjin University
2025
Institute of Hematology & Blood Diseases Hospital
2013-2024
National Clinical Research
2017-2024
Peking University First Hospital
2005-2024
Peking University
2005-2024
Shenyang Center for Disease Control and Prevention
2018-2024
Zhejiang University
2016-2024
Acute kidney injury (AKI) and chronic diseases are associated with high mortality morbidity. Although the underlying mechanisms determining transition from acute to not completely understood, immune-mediated processes critical in renal injury. We have performed a comparison of 2 mouse models leading either regeneration or fibrosis. Using global gene expression profiling we could identify immune-related pathways accounting for majority observed transcriptional changes during Unbiased...
Background and Purpose— Elevated blood homocysteine concentration increases the risk of stroke, especially among hypertensive individuals. Homocysteine is largely affected by methylenetetrahydrofolate reductase C677T polymorphism folate status. Among patients, we aimed to test hypothesis that association between stroke can be modified folic acid intervention. Methods— We analyzed data 20 424 adults enrolled in China Stroke Primary Prevention Trial. The participants, first stratified...
The American Society for Histocompatibility and Immunogenetics HLA common well-documented (CWD) catalog, CWD 2.0.0 catalog European Federation (EFI) have been published, which are useful improving the accuracy of genotyping in laboratories. Here, we studied Chinese catalog. A total 812 211 unrelated volunteer donors from China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy-six alleles at HLA-A, -B, -C, -DRB1, -DQB1 loci defined as population, including 159 517 alleles....
Abstract Schizophrenia (SZ) is a highly heterogeneous disorder in both its symptoms and risk factors. One of the most prevalent genetic factors for SZ hemizygous microdeletion at chromosome 22q11.2 (22q11DS) that confers 25-fold increased risk. Six genes directly disrupted 22qDS encode mitochondrial-localizing proteins. Here, we test hypothesis stem cell-derived neurons from subjects with 22q11DS have mitochondrial deficits relative to typically developing controls. Human iPSCs four lines...
Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for malignant diseases numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only facilitate individual donor searches but also determine the probability with which particular patient can find HLA-matched donors in registry. The frequencies of HLA-A, -B, -C, -DRB1, -DQB1 alleles haplotypes were estimated among 169,995 Chinese volunteers using...
Abstract Objective To identify a DNA marker for the copper toxicosis (CT) locus in Bedlington Terriers (BT). Animals 77 BT, of which 25 were affected. Diagnosis affected or unaffected with CT was made all cases by quantitative determinations on liver biopsy samples use established criteria. Procedure BT pedigrees segregating identified. Linkage studies carried out using polymorphic microsatellite markers developed canine genome these pedigrees. isolated from blood pedigree members....
ABSTRACT Viruses cause about 15% of the cancers that are still leading causes human mortality. The discovery viral oncogenes has enhanced our understanding oncogenesis. However, underlying molecular mechanisms virus-induced complex and require further investigation. present study attempted to investigate effects microRNAs (miRNAs) encoded by Marek's disease virus 1 (MDV1), a chicken herpesvirus causing acute T-cell lymphomas solid visceral tumors in chickens, on anti-cancer drug-induced...
Vascular endothelial growth factor (VEGF)-induced neovasculature is immature and leaky. We tested if coexpression of angiopoietin-1 (ANG1) with VEGF improves blood–brain barrier (BBB) integrity neuroprotective neurorestorative effects using a permanent distal middle cerebral artery occlusion (pMCAO) model. Adult CD-1 mice were injected 2 × 10 9 virus genomes adeno-associated viral vectors expressing (AAV-VEGF) or ANG1 (AAV-ANG1) individually together in 1:1 ratio into the ischemic penumbra 1...
Abstract High pressure extraction (HPE) of astaxanthin from shrimp (Penaeus Vannamei Boone) waste at different (0.1–600 MPa) and holding times (0–20 min), with solvents (acetone, dichloromethane ethanol) solvent to solid ratios (10–50 mL/g) was evaluated, yields quality the extracts were determined. Antioxidant activity extract HPE conventional (at ambient pressure) compared based on DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) superoxide anion radical scavenging potentials. Besides, surfaces shells...
Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context genetic variants carry elevated risk can advance novel treatment approaches these disorders.To test hypothesis mitochondrial compensation is associated with schizophrenia 22q11.2 deletion syndrome (22q11DS).This case-control study compared measures function and expression related genes 14 induced pluripotent stem cell-derived neurons from typically developing control individuals (6 lines)...
N6-methyladenosine RNA modification plays a significant role in the progression of multiple tumorigenesis. Our study identified imperative m6A regulators tumor immune microenvironment, survival, stemness score, and anticancer drug sensitivity pan-cancer. The Wilcox test was to identify differential expression between 17 across 33 TCGA cancer types their normal tissues from UCSC Xena GDC Survival analysis m6A-related using “survival” “survminer” package. Spearman correlation Pearson were used...
The site-specific recombination system is a versatile tool in genome engineering, enabling controlled DNA inversion or deletion at specific sites to generate genetic diversity. multiplexed system, which preferentially facilitates reverse-oriented rather than same-oriented sites, has not been found eukaryotes. Here, we establish Rci51-5/multi-sfxa101, yeast. Firstly, develop high-throughput screening based on the on/off transcriptional control of multiple markers by inversion. After two...