A5100406416- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Sodium Intake and Health
- Heart Rate Variability and Autonomic Control
- Folate and B Vitamins Research
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Traditional Chinese Medicine Studies
- Cardiovascular Health and Risk Factors
- Inflammatory mediators and NSAID effects
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrovascular and Carotid Artery Diseases
- Nutrition, Genetics, and Disease
- Esophageal and GI Pathology
- Diabetes Treatment and Management
- GDF15 and Related Biomarkers
- Signaling Pathways in Disease
- Renin-Angiotensin System Studies
- Hemodynamic Monitoring and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Viral Infections and Immunology Research
Peking University
2016-2025
Peking University People's Hospital
2016-2025
Beijing Haidian Hospital
2024
Institute of Microbiology
2023
Chinese Academy of Sciences
2023
Beijing Tsinghua Chang Gung Hospital
2021
Anhui Medical University
2017-2020
Johns Hopkins University
2016-2020
Peking University First Hospital
2016-2020
Air Force Medical University
2016-2020
<h3>Importance</h3> Uncertainty remains about the efficacy of folic acid therapy for primary prevention stroke because limited and inconsistent data. <h3>Objective</h3> To test hypothesis that with enalapril is more effective in reducing first than alone among Chinese adults hypertension. <h3>Design, Setting, Participants</h3> The China Stroke Primary Prevention Trial, a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, 32 communities Jiangsu Anhui...
Abstract— LCZ696 (Japanese adopted name: sucabitril valsartan sodium hydrate), a first-in-class angiotensin receptor neprilysin inhibitor, concomitantly inhibits and blocks type 1 receptor. This randomized, double-blind, placebo-controlled study, the first in Asia for this drug, evaluated dose-related efficacy safety of patients with hypertension using 24-hour ambulatory blood pressure (BP) monitoring. Asian aged ≥18 years (n=389) were randomized to receive 100 mg (n=100), 200 (n=101), 400...
Background and Purpose— Elevated blood homocysteine concentration increases the risk of stroke, especially among hypertensive individuals. Homocysteine is largely affected by methylenetetrahydrofolate reductase C677T polymorphism folate status. Among patients, we aimed to test hypothesis that association between stroke can be modified folic acid intervention. Methods— We analyzed data 20 424 adults enrolled in China Stroke Primary Prevention Trial. The participants, first stratified...
We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from CSPPT (China Stroke Primary Prevention Trial), double-blind, randomized controlled trial.A 20 702 hypertensive adults without history major cardiovascular disease were randomly assigned double-blind daily treatment an enalapril 10-mg and 0.8-mg tablet or alone. The primary outcome was stroke.The median...
<h3>Objective:</h3> To examine whether a change in serum total homocysteine (tHcy) levels is associated with first stroke risk post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT). <h3>Methods:</h3> We analyzed 16,867 participants CSPPT tHcy measurements at both baseline and exit visits. The primary outcome was stroke. secondary composite cardiovascular events consisting death, myocardial infarction, percent decline calculated as [(baseline − tHcy)/baseline × 100]....
We evaluated the interaction of serum folate and vitamin B12 with methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on risk first ischemic stroke efficacy folic acid treatment in prevention stroke.A total 20,702 hypertensive adults were randomized to a double-blind daily enalapril 10 mg 0.8 or alone. Participants followed up every 3 months.Median values concentrations at baseline 8.1 ng/mL 280.2 pmol/L, respectively. Over median 4.5 years, among those not receiving acid,...
Previous trials of renal denervation (RDN) have been designed to investigate reduction blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified success. It is an unmet clinical need map nerves, selectively denervate sympathetic provide readouts for interventionalists and avoid futile RDN. We aimed examine safety nerve mapping/selective (msRDN) in patients with uncontrolled hypertension (HTN) determine whether antihypertensive drug burden...
The spot urine method as an alternative approach in estimating daily sodium excretion has been proposed for many years. Kawasaki created equation to predict urinary using second morning (SMU) samples which was obtained before breakfast after initial voiding upon arising. Tanaka developed another by examining submitted at random times during the day. A newly published study that “PM sample,” collected late afternoon or early evening dinner, showed a stronger relationship with actual...
We aimed to investigate the prevalence of hyperhomocysteinaemia (total plasma homocysteine (tHcy) ≥ 10 μmol/l) and its major determinants in rural Chinese hypertensive patients. A cross-sectional investigation was carried out Lianyungang Jiangsu province, China. This analysis included 13 946 adults. The 51·6 % (42·7 women 65·6 men). OR were 1·52 (95 CI 1·39, 1·67) 2·32 2·07, 2·61) for participants aged 55–65 65–75 v . 45–55 years; 1·27 1·18, 1·37) with a BMI 25 < kg/m 2 ; 1·14 1·06, 1·23)...
Pulse wave velocity (PWV) has been shown to influence the effects of antihypertensive drugs in prevention cardiovascular diseases. Data are limited on whether PWV is an independent predictor stroke above and beyond hypertension control. This longitudinal analysis examined joint effect brachial-ankle (baPWV) with control risk first stroke. report included 3310 hypertensive adults, a subset China Stroke Primary Prevention Trial (CSPPT) baseline measurements for baPWV. During median follow-up...
We aimed to examine whether baseline homocysteine (Hcy) concentrations affect antihypertensive responses enalapril treatment among previously untreated hypertensive patients (n=10 783) in the CSPPT (China Stroke Primary Prevention Trial).After a 3-week run-in with daily dose of 10 mg enalapril, eligible were randomly assigned double-blind tablet either (10 mg) and folic acid (0.8 or alone for median 4.5 years. After period alone, systolic blood pressure-lowering effect was significantly...
We aimed to investigate the relationship of time-averaged on-treatment systolic blood pressure (SBP) with risk first stroke in CSPPT (China Stroke Primary Prevention Trial). A post hoc analysis was conducted using data from 17 720 hypertensive adults without cardiovascular disease, diabetes mellitus, and renal function decline CSPPT, a randomized double-blind controlled trial. The primary outcome stroke. Over median follow-up duration 4.5 years, association between averaged SBP for stoke...
Objective— This post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial) assessed individual variation in total homocysteine (tHcy)–lowering response after an average 4.5 years 0.8 mg daily folic acid therapy Chinese hypertensive adults and evaluated effect modification by methylenetetrahydrofolate reductase ( MTHFR ) C677T genotypes serum folate levels. Approach Results— included 16 413 participants from CSPPT, who were randomly assigned to 2 double-blind treatment groups:...
This study investigated the relationship between rs4673 of nicotinamide adenine dinucleotide phosphate oxidase p22PHOX gene and blood pressure (BP) response to acute salt loading in a Chinese population diagnosed with essential hypertension. An test was performed using 2 L normal saline (NS) infused over 4 hours. BP heart rate were recorded immediately after NS infusion hourly for next 3 Data analysis chi-squared test, Student t multivariable regression. A total 159 patients analyzed,...
Objective ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. Therefore, current study determined association enalapril-induced cough Chinese patients essential hypertension. Methods A total 450 hypertensive treated 10 mg enalapril maleate were genotyped for using PCR-direct sequencing method. Cough was recorded when bothered by...
Abstract Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. Cough the most common adverse reaction enalapril. We investigate whether SLCO1B1 genetic polymorphisms, previously reported to be important determinants inter-individual variability enalapril pharmacokinetics, are associated with enalapril-induced cough. A cohort 450 patients essential hypertension 10 mg maleate were genotyped for...