Lisheng Liu
A5101545259- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Global Public Health Policies and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Vasculitis and related conditions
- RNA modifications and cancer
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Consumer Attitudes and Food Labeling
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
Shanghai Institute of Hypertension
2012-2025
Shandong Tumor Hospital
2014-2024
Academy of Medical Sciences
1987-2024
Chongqing Cancer Hospital
2020-2024
Chongqing University
2020-2024
Shandong First Medical University
2014-2024
National Clinical Research Center for Digestive Diseases
2010-2022
Shandong University
2017-2022
Creative Commons
2022
Shandong Normal University
2017-2021
In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain.We randomly assigned 11,140 diabetes to undergo either standard or control, defined as use gliclazide (modified release) plus other drugs required achieve a glycated hemoglobin value 6.5% less. Primary end points were composites major macrovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke) and microvascular (new worsening nephropathy...
The optimal range of sodium intake for cardiovascular health is controversial.We obtained morning fasting urine samples from 101,945 persons in 17 countries and estimated 24-hour potassium excretion (used as a surrogate intake). We examined the association between urinary composite outcome death major events.The mean was 4.93 g per day 2.12 day, respectively. With follow-up 3.7 years, occurred 3317 participants (3.3%). As compared with an 4.00 to 5.99 (reference range), higher (≥ 7.00 day)...
In the Action in Diabetes and Vascular Disease: Preterax Diamicron Modified Release Controlled Evaluation (ADVANCE) factorial trial, combination of perindopril indapamide reduced mortality among patients with type 2 diabetes, but intensive glucose control, targeting a glycated hemoglobin level less than 6.5%, did not. We now report results 6-year post-trial follow-up.We invited surviving participants, who had previously been assigned to perindopril-indapamide or placebo standard control...
The association between intake of fruits, vegetables, and legumes with cardiovascular disease deaths has been investigated extensively in Europe, the USA, Japan, China, but little or no data are available from Middle East, South America, Africa, south Asia.We did a prospective cohort study (Prospective Urban Rural Epidemiology [PURE] 135 335 individuals aged 35 to 70 years without 613 communities 18 low-income, middle-income, high-income countries seven geographical regions: North America...
Background WHO has played a leading role in the formulation and promulgation of standard criteria for diagnosis coronary heart disease myocardial infarction since early 1970s. Methods The revised definition takes into consideration following: well-resourced settings can use ESC/ACC/AHA/WHF definition, which new biomarkers as compulsory feature; resource-constrained settings, typical biomarker pattern cannot be made feature necessary assays may not available; must also have provision...
Rapid socioeconomic progress has greatly affected the lifestyle in China. Consequently, owing to changes, urbanization, and accelerated population aging, risk of cardiovascular diseases (CVD) increased. The incidence CVD been increasing continuously this upward trend is projected continue next decade. growing burden become a major public health issue. Accordingly, since 2005, National Center for Cardiovascular Diseases China directed experts cardiology, neurology, nephrology, diabetes,...
Background— In the Apixaban for Reduction in Stroke and Other Thromboembolic Events Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced stroke systemic embolism, major bleeding, mortality. We evaluated treatment effects relation to 2 predictions of time therapeutic range (TTR). Methods Results— The trial randomized 18 201 patients atrial fibrillation 5 mg twice daily or at least 12 months. For each patient, a center average TTR was estimated use linear mixed model...
Noncommunicable diseases (NCDs) accounted for more than two thirds of total deaths globally and 40% NCD in patients younger 70 years. The majority (82%) the premature were from low- middle-income countries.1 Cost-effective interventions prevention management NCDs are available. However, these often not accessible to poor, especially resource-constrained settings. Because lack appropriate care, many people suffering unnecessarily preventable associated complications.2 World Health...
Abstract Aims To examine the incidence of cardiovascular disease (CVD) and mortality in China key subpopulations, to estimate population-level risks attributable 12 common modifiable risk factors for each outcome. Methods results In this prospective cohort 47 262 middle-aged participants from 115 urban rural communities provinces China, it was examined how CVD rates varied by sex, urban-rural area, region. without prior CVD, population-attributable fractions (PAFs) death related were...
Long noncoding RNA (lncRNA) HOX transcript antisense (HOTAIR) acts as an oncogene in gastric cancer development. HOTAIR could induce genome‐wide retargeting of polycomb‐repressive complex 2, trimethylates histone H3 lysine‐27 (H3K27me3) and deregulation multiple downstream genes. Additionally, the ceRNA miR‐331–3p, may modulate HER2 cells. We hypothesized that functional single nucleotide polymorphisms (SNP) affect expression and/or its function and, thus, risk. examined association between...
The risk factors for cardiovascular diseases (CVDs) are more prevalent in the Chinese population, and therefore, increase incidence of CVD. In general, CVD morbidity mortality will remain an upward trend next 10 years. Cardiovascular disease is leading cause death China, which accounts >40% deaths from any cause. burden substantial has become important public health issue. Measures prevention treatment China should be further enforced without delay. Since 2005, National Center Diseases...
The present study aimed to investigate the overall changes in exosomal proteomes metastatic and non‐metastatic non‐small‐cell lung cancers ( NSCLC ) healthy human serum samples, evaluate potential of biomarkers predict metastasis. Tandem mass tags combined with multidimensional liquid chromatography spectrometry analysis were used for screening proteomic profiles samples. Quantitative proteome, significant pathway, functional categories patients donors investigated. In total, 552 proteins...
OBJECTIVE Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis in type 2 diabetes, but the relationship between other vascular diseases and PAD has been poorly investigated. We examined impact previous microvascular macrovascular on risk major patients with diabetes. RESEARCH DESIGN AND METHODS analyzed 10,624 diabetes free from baseline Action Diabetes Vascular Disease: Preterax Diamicron MR Controlled Evaluation (ADVANCE) clinical trial. The primary composite...
Background Most cardiovascular diseases occur in low‐ and middle‐income regions of the world, but socioeconomic distribution within China remains unclear. Our study aims to investigate whether prevalence differs among high‐, middle‐, low‐income explore reasons for disparities. Methods Results We enrolled 46 285 individuals from 115 urban rural communities 12 provinces across between 2005 2009. recorded their medical histories calculated INTERHEART Risk Score assessment risk‐factor burden,...