A5087653918- Plant Pathogens and Fungal Diseases
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Plant-Microbe Interactions and Immunity
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Viral gastroenteritis research and epidemiology
- Plant Disease Resistance and Genetics
- Virus-based gene therapy research
- Plant Pathogenic Bacteria Studies
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Advances in Cucurbitaceae Research
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Growth Hormone and Insulin-like Growth Factors
- Ferroelectric and Piezoelectric Materials
- Animal Virus Infections Studies
- Microbial Community Ecology and Physiology
- Toxin Mechanisms and Immunotoxins
Kashi University
2025
First Affiliated Hospital of Wannan Medical College
2019-2025
Hangzhou Normal University
2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Shanghai Academy of Agricultural Sciences
2015-2024
Fujian Agriculture and Forestry University
2014-2024
Jilin Agricultural University
2023-2024
Jinan University
2015-2024
Shanghai University of Engineering Science
2013-2024
Autophagic responses to chemotherapeutic agents may vary greatly among different prostate cancer cells and have not been well characterized. In this study, we showed that valproic acid (VPA) induced conversion of LC3-I LC3-II formation LC3 puncta, the typical markers autophagy, in LNCaP PC-3 cells. However, these were undetectable DU145 upon autophagic stimulation, indicating a defect autophagy cell line. Among several critical autophagy-related proteins, ATG5 ATG12-ATG5 conjugates, which...
Background Most cardiovascular diseases occur in low‐ and middle‐income regions of the world, but socioeconomic distribution within China remains unclear. Our study aims to investigate whether prevalence differs among high‐, middle‐, low‐income explore reasons for disparities. Methods Results We enrolled 46 285 individuals from 115 urban rural communities 12 provinces across between 2005 2009. recorded their medical histories calculated INTERHEART Risk Score assessment risk‐factor burden,...
Information on surgical site infection (SSI) after treatment of ankle fracture is limited and remains controversial. The purpose the present study was to determine incidence risk factors for SSI open reduction internal fixation (ORIF) fracture. Patients who underwent ORIF at 3 centers between January 2015 December 2016 were included. potential included demographic variables, including age, sex, body mass index (BMI), hypertension, diabetes mellitus, heart disease, smoking, excessive alcohol...
Background The predictive value of adiposity indices and the newly developed index for cardiometabolic risk factors cardiovascular diseases ( CVD s) remains unclear in Chinese population. This study aimed to compare A Body Shape Index with other 5 conventional obesity‐related anthropometric (body mass index, waist circumference, hip waist‐to‐hip ratio, waist‐to‐height ratio) Methods Results total 44 048 participants were derived from baseline data PURE ‐China (Prospective Urban Rural...
Abstract Using a PCR‐based cloning technique, we have isolated series of DNA fragments coding for tyrosine kinases that are expressed in metastatic human colon tumor, and subsequently analyzed their expression pattern at the protein level tumors. We identified both α β forms platelet‐derived growth factor receptor (PDGFR), axl 8 other genes, including 3 cytoplasmic kinases. To study cancer, performed Western blots matched sets normal tissues carcinomas from same patient. These revealed...
The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of has been linked to variety inflammatory diseases. Thus targeting represents promising therapeutic for treatment such Scutellarin is flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz. and reported exhibit potent anti-inflammatory activities, underlying mechanism only partly understood. In this study, we aimed investigate whether...
ATP is released by bacteria and host cells during bacterial infection as well sterile tissue injury, acting an inducer of inflammasome activation. Previous studies have shown that treatment leads to AMP-activated protein kinase (AMPK) However, it unclear whether AMPK signaling has been involved in the regulation ATP-induced activation subsequent pyroptosis. In this study, we aimed investigate issue lipopolysaccharide-activated murine macrophages. Our results showed was activated macrophages...
Changes in fungal communities associated with healthy and diseased pea roots were investigated using deep amplicon pyrosequencing three spatial compartments: roots, rhizosphere, surrounding soil. Thirty root systems collected from fields, half of which showing clear symptoms rot. In total, 500 461 internal transcribed spacer-1 sequences obtained that clustered into 123 (roots), 271 (rhizosphere), 440 (bulk soil) nonsingleton operational taxonomic units (OTUs). Species richness was highest...
Abstract Objective Induction of secondary necrosis/pyroptosis contributes to the toxicity chemotherapeutic drugs , in which gasdermin E (GSDME) plays critical roles. This study aimed explore whether GSDME is involved mediating cytotoxic effects cisplatin and doxorubicin on mouse macrophages. Methods RAW 264.7 cells bone marrow‐derived macrophages (BMDMs) were treated with or doxorubicin. Propidium iodide staining was used assay necrosis, immunoblotting performed detect protein expression....
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used cancer therapy, has any influences on activation. Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced indicated by increased release cleaved caspase-1 mature IL-1β, formation...
Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but underlying mechanism unclear. Here we aimed to explore whether evodiamine influenced NLRP3 (NLR family, pyrin containing domain 3) inflammasome activation in macrophages, critical defending host against pathogenic infections. We uncovered that dose-dependently enhanced lipopolysaccharide-primed as indicated by...
Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis that has critical role in defensing against bacterial infection, whereas its excess activation under pathogenic circumstances may cause various inflammatory diseases. However, there are few known drugs can control activation. We report here scutellarin, a flavonoid from Erigeron breviscapus, acted as an inhibitor for macrophages. Scutellarin dose-dependently inhibited LPS-induced...
Taraxasterol (TAS) is an active ingredient of Dandelion ( Taraxacum mongolicum Hand. -Mazz.), a medicinal plant that has long been used in China for treatment inflammatory disorders. But the underlying mechanism its therapeutic effects on disorders not completely clear. Inflammasome activation critical step innate immune response to infection and aseptic inflammation. Among various types inflammasome sensors reported, NLR family pyrin domain containing 3 (NLRP3) implicated diseases therefore...