A5100421080- T-cell and Retrovirus Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Graphene and Nanomaterials Applications
- Functional Brain Connectivity Studies
- Advanced Thermoelectric Materials and Devices
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Fullerene Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Catalytic Processes in Materials Science
- Nanoparticles: synthesis and applications
- Metal-Organic Frameworks: Synthesis and Applications
- EEG and Brain-Computer Interfaces
- Extracellular vesicles in disease
- Synthesis and Characterization of Heterocyclic Compounds
- Chalcogenide Semiconductor Thin Films
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
China University of Petroleum, East China
2023-2025
Women's Hospital, School of Medicine, Zhejiang University
2020-2025
Sichuan University
2009-2025
State Key Laboratory of Oral Diseases
2023-2025
Institute of High Energy Physics
2016-2025
University of Chinese Academy of Sciences
2014-2025
Second Hospital of Shandong University
2013-2025
Huazhong University of Science and Technology
2013-2025
Tongji Hospital
2017-2025
Sun Yat-sen University
2000-2025
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
In this phase 2, randomized, double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for treatment moderate-to-severe plaque psoriasis.We randomly assigned patients with score 12 or higher on psoriasis area-and-severity index (PASI, which scores range from 0 to 72, indicating more severe disease) 10% their body-surface area affected by receive (70 mg, 140 210 mg at day 1 weeks...
We report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating chitosan, these functionalized have been developed as chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered delivery, facilitating the combination of chemotherapy and photothermal therapy into one system cancer therapy. Loaded doxorubicin could be controllably released upon effect...
The bactericidal action of silver (0) nanoparticles and amoxicillin on Escherichia coli is studied, respectively. Increasing concentration both (0–0.525 mg ml−1) (0–40 µg showed a higher antibacterial effect in Luria–Bertani (LB) medium. cells have different sensitivity to them. When are combined, it results greater efficiency than when they were applied separately. Dynamic tests bacterial growth indicated that exponential stationary phases greatly decreased delayed the synergistic...
Herein, a novel fluorescence sensor based on g-C3N4 nanosheet-MnO2 sandwich nanocomposite has been developed for rapid and selective sensing of glutathione (GSH) in aqueous solutions, as well living cells. The graphitic-phase C3N4 (g-C3N4) nanosheet used here is new type carbon-based nanomaterial with high quantum yield specific surface area. We demonstrate facile one-step approach the synthesis first time. this quenched, which attributing to resonance energy transfer (FRET) from deposited...
We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver into cells.
The ability of animals to respond life-threatening stimuli is essential for survival. Although vision provides one the major sensory inputs detecting threats across animal species, circuitry underlying defensive responses visual remains poorly defined. Here, we investigate innate behaviours elicited by predator-like in mice. Our results demonstrate that neurons superior colliculus (SC) are a variety acute and persistent overhead looming stimuli. Optogenetic mapping revealed SC projections...
Graphitic-phase carbon nitride (g-C3N4) nanosheets, the newly emerging two-dimensional (2D) layered nanomaterials, have been demonstrated to be promising bioimaging agents due their high photoluminescence (PL) quantum yields, good biocompatibility and low toxicity. However, therapeutic applications of g-C3N4 nanosheets not explored until now. In this study, we proven for first time that can used as efficient photosensitizers photodynamic tumor therapy pH-responsive nanocarriers drug...
A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance (MRI) dual-modal imaging. Moreover, the Se8-DOX shows pH-responsive chemotherapy and enables combination of photothermal therapy to receive superior antitumor efficacy. This work promises further exploration 2D nanoplatforms applications. As a service our authors readers, this journal...
GeTe-based alloys have been intensively considered as p-type thermoelectrics for about 50 years, yet existing literature barely discussed the thermoelectric properties of pristine GeTe at high temperatures (300–800 K). This work first backs to a fundamental understanding on transport inherent GeTe, based more than samples synthesized with expected carrier concentrations ranging from 1 × 1020 3 1021 cm–3. A figure merit zT ∼1.7 is found this compound when it optimally doped Hall concentration...
PbTe and SnTe in their p-type forms have long been considered high-performance thermoelectrics, both of them largely rely on two valence bands (the first band at L point the second one along Σ line) participating transport properties. This work focuses thermoelectric properties inherent to GeTe, a member group IV monotellurides that is relatively less studied. Approximately 50 GeTe samples synthesized with different carrier concentrations spanning from 1 20 × 1020 cm−3, enabling an...
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
In order to locate the optimal carrier concentrations for peaking thermoelectric performance in p-type group IV monotellurides, existing efforts focus on aliovalent doping, either increase (in PbTe) or decrease SnTe and GeTe) hole concentration. The limited solubility of dopants usually introduces insufficient phonon scattering maximization. With a size cation, concentration holes, induced by cation vacancies intrinsic compounds, increases rapidly from ≈1018 cm-3 PbTe ≈1020 then ≈1021 GeTe....
Abstract Many efforts are recently devoted on improving thermoelectric SnTe as an environment—friendly alternative to conventional PbTe and successful approaches include valence band convergence, nanostructuring, substantial/interstitial defects. Among these strategies, alloying with MnTe enables the most effective reduction in offset (between L Σ ) for a convergence due its high solubility of ≈15%, yet there is no indication that enough fully optimizing structure thus maximizing electronic...
Significance Pulmonary alveolar type I (AT1) cells are essential for the gas-exchange function of lungs. AT1 retain their cellular plasticity during injury-induced regeneration. However, we know very little about developmental heterogeneity cell population. Our study identified a robust genetic marker postnatal cells, insulin-like growth factor-binding protein 2 (Igfbp2). We use this to demonstrate that population actually consists two subtypes (Hopx + Igfbp2 and Hopx − cells) with distinct...
Abstract The functionalization methods of materials based on bacterial cellulose (BC) mainly focus the chemical modification or physical coating fermentation products, which may cause several problems, such as environment pollution, low reaction efficiency and easy loss functional moieties during application. Here, we develop a method utilizing in situ microbial combined with 6-carboxyfluorescein-modified glucose (6CF-Glc) substrate using Komagataeibacter sucrofermentans to produce BC...
Abstract Targeting programmed cell death protein 1 (PD‐1)/programmed ligand (PD‐L1) immunologic checkpoint blockade with monoclonal antibodies has achieved recent clinical success in antitumor therapy. However, therapeutic exhibit several issues such as limited tumor penetration, immunogenicity, and costly production. Here, Bristol‐Myers Squibb nanoparticles (NPs) are prepared using a reprecipitation method. The NPs have advantages including passive targeting, hydrophilic nontoxic features,...
Reactive oxygen species (ROS) are crucial molecules in cancer therapy. Unfortunately, the therapeutic efficiency of ROS is unsatisfactory clinic, primarily due to their rigorous production conditions. By taking advantage intrinsic acidity and overproduction H2O2 tumor environment, we have reported an nanoreactor based on core–shell-structured iron carbide (Fe5C2@Fe3O4) nanoparticles (NPs) through catalysis Fenton reaction. These NPs able release ferrous ions acidic environments...
The combination of chemo/chemodynamic therapy is a promising strategy for improving antitumor efficacy. Herein, metal-phenolic network nanoparticles (NPs) self-assembled from copper ions and gallic acid (Cu-GA) are developed to evoke apoptosis cuproptosis synergistic therapy. Cu-GA NPs biodegraded in response the highly expressed glutathione (GSH) tumor cells, resulting simultaneous release Cu+ GA. intracellular GSH content dramatically reduced by released GA, rendering cells incapable...
Abstract Electric signal accelerates full‐thickness wound healing in the clinic, which is usually generated by a large power generation system and requires delicate control authorized personnel. Here, self‐powered flexible biocompatible thermoelectric device with exceptionally high efficiency developed. It generates 10 mV voltage at temperature gradient of K, outperforming all reported devices. Accordingly, it can directly efficiently convert omnipresent heat skin to electricity microvolt...
Antisense oligonucleotide-mediated exon skipping is able to correct out-of-frame mutations in Duchenne muscular dystrophy and restore truncated yet functional dystrophins. However, its application limited by low potency inefficiency systemic delivery, especially failure dystrophin heart. Here, we conjugate a phosphorodiamidate morpholino oligomer with designed cell-penetrating peptide (PPMO) targeting mutated exon. Systemic delivery of the novel PPMO restores almost normal levels cardiac...
ABSTRACT Surveys were carried out to better understand the tick vector ecology and genetic diversity of Huaiyangshan virus (HYSV) in both regions endemicity nonendemicity. Haemaphysalis longicornis ticks dominant endemicity, while Rhipicephalus microplus is more abundant HYSV RNA was found human species, with greater prevalence H. lesser R. . Phylogenetic analyses indicate that a novel species genus Phlebovirus