Xiaohong Chen

ORCID: 0000-0002-9797-8384
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Nanoplatforms for cancer theranostics
  • Advanced biosensing and bioanalysis techniques
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • RNA modifications and cancer
  • Nanoparticle-Based Drug Delivery
  • Analytical Chemistry and Chromatography
  • Radiopharmaceutical Chemistry and Applications
  • Multi-Criteria Decision Making
  • RNA Interference and Gene Delivery
  • Advanced Photocatalysis Techniques
  • Seismic Imaging and Inversion Techniques
  • 2D Materials and Applications
  • Cell Adhesion Molecules Research
  • Plasmonic and Surface Plasmon Research
  • Natural product bioactivities and synthesis
  • Quantum Dots Synthesis And Properties
  • Graphene research and applications
  • Semiconductor Quantum Structures and Devices
  • Photonic and Optical Devices
  • Transportation Planning and Optimization
  • Cancer, Hypoxia, and Metabolism
  • ZnO doping and properties

Sun Yat-sen University
2016-2025

Fujian Medical University
2016-2025

Shanghai Jiao Tong University
2016-2025

Southeast University
2015-2025

Tsinghua University
2016-2025

Beijing Tongren Hospital
2016-2025

National University of Singapore
2010-2025

Jiangsu University of Science and Technology
2005-2025

Southern Medical University
2016-2025

Huazhong University of Science and Technology
2016-2025

<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) is an emerging infectious that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. <h3>Objective</h3> To describe characteristics patients with who developed acute respiratory distress syndrome (ARDS) or died. <h3>Design, Setting, Participants</h3> Retrospective cohort study 201 confirmed admitted to Wuhan Jinyintan...

10.1001/jamainternmed.2020.0994 article EN JAMA Internal Medicine 2020-03-13

The dimensionless thermoelectric figure of merit (ZT) in bismuth antimony telluride (BiSbTe) bulk alloys has remained around 1 for more than 50 years. We show that a peak ZT 1.4 at 100 degrees C can be achieved p-type nanocrystalline BiSbTe alloy. These materials were made by hot pressing nanopowders ball-milled from crystalline ingots under inert conditions. Electrical transport measurements, coupled with microstructure studies and modeling, the improvement is result low thermal...

10.1126/science.1156446 article EN Science 2008-03-21

Significance Carbon has many faces––from diamond and graphite to graphene, nanotube, fullerenes. Whereas hexagons are the primary building blocks of these materials, except for C 20 fullerene, carbon structures made exclusively pentagons not known. Because exotic properties associated with their unique structures, some fundamental questions arise: Is it possible have materials if so will they be stable unusual properties? Based on extensive analyses simulations we show that penta-graphene,...

10.1073/pnas.1416591112 article EN Proceedings of the National Academy of Sciences 2015-02-02
Kyriaki Michailidou Sara Lindström Joe Dennis Jonathan Beesley Shirley Hui and 95 more Siddhartha Kar Audrey Lemaçon Penny Soucy Dylan M. Glubb Asha Rostamianfar Manjeet K. Bolla Qin Wang Jonathan P. Tyrer Ed Dicks Andrew Lee Zhaoming Wang Jamie Allen Renske Keeman Ursula Eilber Juliet D. French Xiaohong Chen Laura Fachal Karen McCue Amy E. McCart Reed Maya Ghoussaini Jason S. Carroll Xia Jiang Hilary K. Finucane Marcia Adams Muriel A. Adank Habibul Ahsan Kristiina Aittomäki Hoda Anton‐Culver Natalia Antonenkova Volker Arndt Kristan J. Aronson Banu K. Arun Paul L. Auer François Bacot Myrto Barrdahl Caroline Baynes Matthias W. Beckmann Sabine Behrens Javier Benı́tez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia Bogdanova Stig E. Bojesen Bernardo Bonanni Anne‐Lise Børresen‐Dale Judith S. Brand Hiltrud Brauch Paul Brennan Hermann Brenner Louise A. Brinton Per Broberg Ian W. Brock Annegien Broeks Angela Brooks‐Wilson Sara Y. Brucker Thomas Brüning Barbara Burwinkel Katja Butterbach Qiuyin Cai Hui Cai Trinidad Caldés Federico Canzian Ángel Carracedo Brian D. Carter Jose E. Castelao Tsun Leung Chan Ting‐Yuan David Cheng Kee Seng Chia Ji‐Yeob Choi Hans Christiansen Christine L. Clarke Margriet Collée Don Conroy Emilie Cordina‐Duverger Sten Cornelissen David G. Cox Angela Cox Simon S. Cross Julie M. Cunningham Kamila Czene Mary B. Daly Peter Devilee Kimberly F. Doheny Thilo Dörk Isabel dos‐Santos‐Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana Eccles Arif B. Ekici A. Heather Eliassen Carolina Ellberg Mingajeva Elvira Christoph Engel

10.1038/nature24284 article EN Nature 2017-10-20

Abstract Chemically functionalized single-walled carbon nanotubes (SWNT) have shown promise in tumor-targeted accumulation mice and exhibit biocompatibility, excretion, little toxicity. Here, we show vivo SWNT drug delivery for tumor suppression mice. We conjugate paclitaxel (PTX), a widely used cancer chemotherapy drug, to branched polyethylene glycol chains on SWNTs via cleavable ester bond obtain water-soluble SWNT-PTX conjugate. affords higher efficacy suppressing growth than clinical...

10.1158/0008-5472.can-08-1468 article EN Cancer Research 2008-08-12

Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...

10.1002/anie.201712027 article EN Angewandte Chemie International Edition 2018-02-28

Carbon-based nanomaterials have been widely used as catalysts or catalyst supports in the chemical industry for energy environmental applications due to their fascinating properties. High surface areas, tunable porosity, and functionalization are considered be crucial enhance catalytic performance of carbon-based materials. Recently, newly emerging metal–organic frameworks (MOFs) built from metal ions polyfunctional organic ligands proved promising self-sacrificing templates precursors...

10.1021/acscatal.6b01222 article EN ACS Catalysis 2016-07-26

Abstract Katalyse mit Methode : Eine ganze Reihe katalytischer Palladiumsysteme für die C‐H‐Aktivierung/C‐C‐Kupplung (siehe Schema) wurde in jüngerer Zeit entwickelt. Ein besonderer Schwerpunkt ist Pd II ‐katalysierte Kupplung von C‐H‐Bindungen metallorganischen Reagentien durch /Pd 0 ‐Katalysezyklen. Die Vielseitigkeit dieser Katalysemethode wird demonstriert, zudem werden offene Fragen sowie das Entwicklungspotenzial des Gebietes angesprochen. magnified image In den letzten zehn Jahren...

10.1002/ange.200806273 article DE Angewandte Chemie 2009-06-25

Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of intravenously injected into animals vivo is currently unknown, an issue critical to potential clinical applications these materials. Here, using the intrinsic Raman spectroscopic signatures single-walled carbon (SWNTs), we measured blood circulation SWNTs and detect various organs tissues mice ex over a period three months. Functionalization by branched polyethylene-glycol (PEG)...

10.1073/pnas.0707654105 article EN Proceedings of the National Academy of Sciences 2008-01-30

We constructed highly oriented and ordered macropores within metal-organic framework (MOF) single crystals, opening up the area of three-dimensional-ordered macro-microporous materials (that is, containing both macro- micropores) in single-crystalline form. Our methodology relies on strong shaping effects a polystyrene nanosphere monolith template double-solvent-induced heterogeneous nucleation approach. This process synergistically enabled situ growth MOFs voids, rendering crystal with...

10.1126/science.aao3403 article EN Science 2018-01-12

Abstract The recently proposed digital coding metasurfaces make it possible to control electromagnetic (EM) waves in real time, and allow the implementation of many different functionalities a programmable way. However, current configurations are only space-encoded, do not exploit temporal dimension. Here, we propose general theory space-time modulated obtain simultaneous manipulations EM both space frequency domains, i.e., propagation direction harmonic power distribution simultaneously. As...

10.1038/s41467-018-06802-0 article EN cc-by Nature Communications 2018-10-12

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...

10.1021/jacs.9b03457 article EN Journal of the American Chemical Society 2019-06-02

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The fluorescence intensity reached maximum at 6 h postinjection with good contrast. results reported here open up new perspectives for integrin-targeted near-infrared optical may aid cancer detection management including imaging-guided surgery.

10.1021/nl052405t article EN Nano Letters 2006-03-11

Two 3d-4f heterometallic coordination polymers {[Ln(PDA)3Mn1.5(H2O)3].3.25H2O}infinity with 1D channels were synthesized under hydrothermal conditions (PDA = pyridine-2,6-dicarboxylic acid; Ln Eu (1); Tb (2)). The emission intensities of 1 and 2 increased significantly upon addition Zn2+, while the introduction other metal ions caused intensity to be either unchanged or weakened. case implies that may used as luminescent probes Zn2+.

10.1021/ja047141b article EN Journal of the American Chemical Society 2004-11-04

Single layer of graphite (graphene) was predicted and later experimentally confirmed to undergo metal-semiconductor transition when fully hydrogenated (graphane). Using density functional theory we show that half the hydrogen in this graphane sheet is removed, resulting semihydrogenated graphene (which refer as graphone) becomes a ferromagnetic semiconductor with small indirect gap. Half-hydrogenation breaks delocalized pi bonding network graphene, leaving electrons unhydrogenated carbon...

10.1021/nl9020733 article EN Nano Letters 2009-08-31
Coming Soon ...