David G. Cox
A5017595704- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Lymphoma Diagnosis and Treatment
- Estrogen and related hormone effects
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Prostate Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Hormonal and reproductive studies
- Molecular Biology Techniques and Applications
Institut de Cancérologie Strasbourg
2021-2025
Inserm
2012-2023
Centre de Recherche en Cancérologie de Lyon
2013-2023
Centre Léon Bérard
2012-2023
National Cancer Institute
2021
Division of Cancer Epidemiology and Genetics
2021
MGH Institute of Health Professions
2021
Imperial College London
2010-2019
Centre National de la Recherche Scientifique
2008-2017
Université Claude Bernard Lyon 1
2011-2017
Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these add existing risk-assessment models is unknown.
A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs risk varied by clinically important tumor characteristics up to 23,039 invasive cases 26,273 controls from 20...
An improved model for risk stratification can be useful guiding public health strategies of breast cancer prevention.
Dicer, a ribonuclease, is the key enzyme required for biogenesis of microRNAs and small interfering RNAs essential both mammalian development cell differentiation. Recent evidence indicates that Dicer may also be involved in tumourigenesis. However, no studies have examined clinical significance at RNA protein levels breast cancer. In this study, biological prognostic value expression was assessed cancer lines, progression cellular models, two well-characterised sets carcinoma samples...
The CYP19A1 gene encodes the enzyme aromatase, which is responsible for final step in biosynthesis of estrogens. In this study, we used a systematic two-step approach that included resequencing and haplotype-based analysis to comprehensively survey common genetic variation across locus relation circulating postmenopausal steroid hormone levels breast cancer risk. This study was conducted among 5,356 invasive cases 7,129 controls comprised primarily White women European descent drawn from...
Abstract Two recent studies independently identified polymorphisms in the 8q24 region, including a single nucleotide polymorphism (rs1447295), strongly associated with prostate cancer risk. Here, we replicate overall association large nested case-control study from National Cancer Institute Breast and Prostate Cohort Consortium using 6,637 cases 7,361 matched controls. We also examine whether this is breast among 2,604 Caucasian 3,118 The rs1447295 marker was Caucasians (P = 1.23 × 10−13)....
Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship increasing of between menarche first full-term pregnancy (FFTP). Studies comprehensive quantitative life-time measures passive an association dose risk. We conducted study within the European Prospective Investigation into Cancer Nutrition to examine active risk invasive possible effect modification by known factors. Among 322,988...
We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2), in a large (n = 337327) heterogeneous cohort women, with 10062 BC case patients after 11.5 years, estimating hazard ratios (HRs) Cox proportional modeling. High total saturated were associated greater risk ER+PR+ disease (HR 1.20, 95% confidence interval [CI] 1.00 to 1.45; HR 1.28, CI 1.09 1.52; highest...
Abstract Introduction Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association body mass index (BMI) negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. Methods Within European EPIC cohort, Cox proportional hazards models were used to describe relationship BMI, waist hip circumferences risk estrogen-receptor (ER) progesterone-receptor (PR) ( n...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
Inflammation plays a key role in the development of colorectal cancers. We have investigated relationship between PTGS2 (COX2) polymorphisms and cancer risk hospital based case–control study. recruited 292 patients with 274 controls from new admitted to Bellvitge Hospital, Barcelona, Spain, 1996 1998. Subjects responded questionnaire on factors. Genotypes eight more frequent were determined. Two are located promoter sequence, one untranslated region exon 1, 3, intron 5, two 10, downstream...