Rudolf Kaaks
A5033124357- Cancer Risks and Factors
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Nutrition and Health in Aging
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Endometrial and Cervical Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Hormonal and reproductive studies
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
German Cancer Research Center
2016-2025
Heidelberg University
2016-2025
DKFZ-ZMBH Alliance
2011-2025
German Center for Lung Research
2016-2024
Hudson Institute
2023-2024
John Wiley & Sons (United States)
2016-2024
Liechtenstein Institute
2024
Centre International de Recherche sur le Cancer
2002-2023
University of Oulu
2023
Borealis (Finland)
2023
Previous studies have relied predominantly on the body-mass index (BMI, weight in kilograms divided by square of height meters) to assess association adiposity with risk death, but few examined whether distribution body fat contributes prediction death.We BMI, waist circumference, and waist-to-hip ratio death among 359,387 participants from nine countries European Prospective Investigation into Cancer Nutrition (EPIC). We used a Cox regression analysis, age as time variable, stratified...
Abstract The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition cancer, with potential for studying other diseases as well. currently includes 519 978 participants (366 521 women 153 457 men, mostly aged 35–70 years) in 23 centres located 10 countries, be followed cancer incidence cause-specific mortality several decades. At enrolment, which took place 1992 2000 at...
Abstract Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) estimate 10-year fatal non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40–69 years Europe. Methods results We derived models using individual-participant data from 45 cohorts 13 countries (677 684 individuals, 30 121 events). used sex-specific competing risk-adjusted models, including age, smoking status, systolic blood pressure,...
Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish may be a decreased risk, but the existing less convincing.
BackgroundLow-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous disease.MethodsWe did a combined analysis of three large-scale sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, the UK Biobank). We characterised...
The evidence for anthropometric factors influencing breast cancer risk is accumulating, but uncertainties remain concerning the role of fat distribution and potential effect modifiers. We used data from 73,542 premenopausal 103,344 postmenopausal women 9 European countries, taking part in EPIC study. RRs Cox regression models were calculated, using measured height, weight, BMI waist hip circumferences; categorized by cohort-wide quintiles; expressed as continuous variables, adjusted study...
Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist women. This discrepancy may be differences fat distribution between sexes the use hormone replacement therapy (HRT) women.We used multivariable adjusted Cox proportional hazards models examine association anthropometric measures risks rectal among 368 277 men women who were free at baseline from nine countries European Prospective Investigation Into Cancer...
Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids — notably androgens oestrogens promote breast tumour development. In spite of this evidence, postmenopausal androgen replacement therapy with dehydroepiandrosterone (DHEA) or testosterone has been advocated for the prevention osteoporosis improved sexual well-being. We have conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition. Levels DHEA...
It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit vegetable overall risk.We conducted a prospective analysis the European Prospective Investigation into Cancer Nutrition (EPIC) cohort assess relationships total fruits, vegetables, vegetables combined risk during 1992-2000. Detailed information on dietary habit lifestyle...
An understanding of the etiologic heterogeneity ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, lifestyle factors by histologic subtype in Ovarian Cancer Cohort Consortium (OC3).
Recently, some US cohorts have shown a moderate association between red and processed meat consumption mortality supporting the results of previous studies among vegetarians. The aim this study was to examine meat, poultry with risk early death in European Prospective Investigation into Cancer Nutrition (EPIC).Included analysis were 448,568 men women without prevalent cancer, stroke, or myocardial infarction, complete information on diet, smoking, physical activity body mass index, who 35 69...
Background: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, both an or lack adrenal androgens (dehydroepiandrosterone [DHEA] its sulfate [DHEAS]) as risk factors. We conducted a case–control study nested within European Prospective Investigation into Cancer Nutrition cohort to examine associations serum concentrations subsequent...
Transplantation tolerance is induced reliably in experimental animals following intrathymic inoculation with the relevant donor strain Ags; however, immunological mechanisms responsible for induction and maintenance of tolerant state remain unknown. We investigated these using TCR transgenic mice (TS1) that carry T cells specific an immunodominant, MHC class II-restricted peptide (S1) influenza PR8 hemagglutinin (HA) molecule. demonstrated TS1 reject skin grafts have transgene-encoded HA...