Peter Broderick
A5059774512- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Immunodeficiency and Autoimmune Disorders
- Genomics and Rare Diseases
- Molecular Biology Techniques and Applications
- Cinema and Media Studies
- Lung Cancer Diagnosis and Treatment
Institute of Cancer Research
2016-2025
Cancer Genetics (United States)
2008-2023
MRC Epidemiology Unit
2015-2017
Centre for Human Genetics
2012
London School of Hygiene & Tropical Medicine
2012
MRC Centre for Reproductive Health
2012
The Queen's Medical Research Institute
2012
University of Edinburgh
2012
Royal Marsden NHS Foundation Trust
2012
Royal Marsden Hospital
2009-2012
Nontoxic multinodular goiter (MNG) is frequently observed in the general population, but little known about underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual with a Sertoli-Leydig cell tumor ovary (SLCT). Germline mutations DICER1, gene codes for an RNase III endoribonuclease, identified affected by pleuropulmonary blastoma (PPB), some whom include gonadal tumors such...
Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci not yet been discovered. We compared 296 114 tagging single-nucleotide polymorphisms in 1694 case subjects (92% two primary cancers or at least affected first-degree relatives) and 2365 control subjects, validation three independent series totaling 11 880 12 487 subjects. Odds ratios (ORs) 95% confidence...
Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has strong heritable basis. We report genome-wide association analysis 34,627 CRC cases 71,379 controls European ancestry that identifies SNPs at 31 new risk loci. also identify eight independent the previously reported loci, further nine loci only identified in Asian populations. use situ promoter capture Hi-C (CHi-C), gene expression, silico annotation methods to likely target genes SNPs. Whilst...
Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several these tagSNPs near bone morphogenetic protein (BMP) pathway loci. The penalty multiple testing implicit in GWAS increases attraction complementary approaches for disease gene discovery, including candidate gene- or pathway-based analyses. strongest loci additional predisposition SNPs arguably those already known...
Abstract Testicular germ cell tumours (TGCTs) are the most common cancer in young men. Here we perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study cancer's mutational profile. The mutation rate is uniformly low all (mean 0.5 mutations per Mb) as compared with cancers, consistent embryological origin TGCT. In addition expected copy number gain chromosome 12p and KIT , identify recurrent tumour suppressor gene CDC27 (11.9%). Copy analysis reveals recurring amplification...