A5062479120- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Immunodeficiency and Autoimmune Disorders
- Chromosomal and Genetic Variations
- Autism Spectrum Disorder Research
- Galectins and Cancer Biology
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Mast cells and histamine
- Advanced Optimization Algorithms Research
- Oropharyngeal Anatomy and Pathologies
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Estrogen and related hormone effects
- Urological Disorders and Treatments
- Congenital heart defects research
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Control Systems and Identification
University of Tehran
2020-2021
Tehran University of Medical Sciences
2020
Ibn Sina Hospital
2015
HIA du Val-de-Grâce à Paris
2014
Hôpital Militaire Avicenne
2014
Uppsala University
2005-2011
Premature ovarian failure (POF) is characterized by hypergonadotropic hypogonadism and amenorrhea before the age of 40. The condition has a heterogeneous background but genetic factors are demonstrated occurrence familial cases. We identified mother daughter with POF both whom carry an X;autosome translocation [t(X;11)(q24;q13)]. RNA expression studies genes flanking X-chromosome breakpoint revealed that patients have reduced levels gene Progesterone Receptor Membrane Component-1 (PGRMC1)....
Abstract Screening for gene copy‐number alterations (CNAs) has improved by applying genome‐wide microarrays, where SNP arrays also allow analysis of loss heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high‐resolution platforms: BAC (32K), oligonucleotide (185K, Agilent), and two (250K, Affymetrix 317K, Illumina). Cross‐platform comparison revealed 29 concordantly detected CNAs, including known recurrent alterations, which confirmed...
Background: The advent of digital technology has profoundly impacted the field education, effectively removing limitations and enhancing learning environment. Blended learning, which combines face-to-face instruction with online components, addresses barriers to fosters higher-order cognitive skills, resulting in increased student satisfaction improved outcomes medical education. Objectives: This study aimed identify key motivational components construct a comprehensive model that can...
Background The existence of multiple subsets chronic lymphocytic leukemia expressing ‘stereotyped’ B-cell receptors implies the involvement antigen(s) in leukemogenesis. Studies also indicate that ‘stereotypy’ may influence clinical course patients with leukemia, for example, stereotyped IGHV3-21 and IGHV4-34 receptors; however, little is known regarding genomic profile these subsets.Design Methods We applied 250K single nucleotide polymorphism-arrays to study copy-number aberrations neutral...
Summary A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify further explore the relationship between these variants risk we genotyped case‐control datasets from Spain Sweden (824 cases, 850 controls). Combined data statistically significant support for an genotypes...
Background Numerous subsets of patients with chronic lymphocytic leukemia display similar immunoglobulin gene usage almost identical complementarity determining region 3 sequences. Among IGHV4-34 cases, two such "stereotyped" B-cell receptors were recently identified, i.e. subset #4 (IGHV4-34/IGKV2-30) and #16 (IGHV4-34/IGKV3-20). Subset appear to share biological clinical features, e.g. young age at diagnosis indolent disease, whereas little is known about a level.Design Methods We...
Abstract Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) and numerous copy number aberrations (CNAs). Recently, gene expression profiling defined a proliferation signature in MCL where high scores predict shorter survival. We investigated 31 cases using high‐density single nucleotide polymorphism arrays correlated CNA patterns with clinical data. Many recurrent CNAs typical of were detected, including losses at 1p (55%), 8p (29%), 9q 11q 13q (42%) 17p (32%), gains 3q...
The autism spectrum disorder (ASD) is a heterogenous condition characterized by impaired socialization and communication in association with stereotypic behaviors. ASD highly heritable heterogeneous complex genetic etiology. Recurrent submicroscopic deletions or duplications have been identified subgroup of individuals using array technology. Adequate testing for these genomic imbalances not yet widely implemented the diagnostic setting due to lack feasible cost-effective methods as well...
Abstract We identified a paracentric inversion of chromosome 10 [inv(10)(q11.22q21.1)] in 0.20% Swedish individuals (15/7,439) referred for cytogenetic analysis. A retrospective analysis 8,896 karyotypes from amniocenteses Sweden revealed carrier frequency 0.079% (7/8,896) the inversion. Cloning and detailed breakpoint regions show enrichment interspersed repeat elements AT‐stretches. The centromeric coincides with that predicted HapMap data, which suggests this region is involved several...
Abstract T‐cell leukemia/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding molecular subtypes, where poor‐risk patients demonstrated higher levels. Here, we examined the mRNA of TCL1 144 with CLL, including 67 immunoglobulin heavy‐chain variable (IGHV) mutated, 58 IGHV unmutated and 19 IGHV3‐21 usage. A level detected CLL vs. mutated genes ( P < 0.001), whereas no difference within cohort (i.e., stereotyped...
About 10% of metastatic urothelial carcinoma overexpress oncogenic HER2/neu receptor.Recent preliminary data suggest that patients with this particular molecular subset could benefit from trastuzumab therapy, which specifically targets the receptor and thus inhibits downstream activation pathway.Here we report a case illustrating clinical benefit, complete response reported as third line therapy in heavily pretreated patient diffuse bladder.It also highlights usefulness 18-Fluorodeoxyglucose...
Recurrent genomic aberrations in chronic lymphocytic leukaemia (CLL) are important predictors of clinical outcome. Deletion 13q14 is the most frequent aberration, found >50% patients, and associated with a favourable prognosis. The deleted region harbours two microRNAs, mir-15a mir-16-1 , shown to regulate BCL2 expression, an anti-apoptotic gene that upregulated CLL. 11q, encompassing ATM gene, present 12–18% patients poor 17p, which includes TP53 defines worst prognostic category...