A5027011147- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Estrogen and related hormone effects
- Cervical Cancer and HPV Research
- Birth, Development, and Health
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Metabolism, Diabetes, and Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Chronic Lymphocytic Leukemia Research
Karolinska Institutet
2016-2025
University of Oslo
2016-2025
Oslo University Hospital
2012-2025
Harvard University
2015-2024
University of Oxford
2009-2023
American Society of Safety Professionals
2023
Harvard University Press
1999-2022
University of Milano-Bicocca
2014-2021
University of Teramo
2021
Stockholm Health Care Services
2021
In 2008, we reported that radical prostatectomy, as compared with watchful waiting, reduces the rate of death from prostate cancer. After an additional 3 years follow-up, now report estimated 15-year results.From October 1989 through February 1999, randomly assigned 695 men early cancer to waiting or prostatectomy. Follow-up was complete December 2009, histopathological review biopsy and radical-prostatectomy specimens blinded evaluation causes death. Relative risks, 95% confidence...
The risk of colorectal cancer is increased among patients with ulcerative colitis. magnitude this increase in and the effects length follow-up, extent disease at diagnosis, age diagnosis vary substantially different studies.
Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association cancer is not well understood.
In 2002, we reported the initial results of a trial comparing radical prostatectomy with watchful waiting in management early prostate cancer. After three more years follow-up, report estimated 10-year results.From October 1989 through February 1999, 695 men cancer (mean age, 64.7 years) were randomly assigned to (347 men) or (348 men). The follow-up was complete 2003, blinded evaluation causes death. primary end point death due cancer; secondary points from any cause, metastasis, and local...
Radical prostatectomy reduces mortality among men with localized prostate cancer; however, important questions regarding long-term benefit remain.Between 1989 and 1999, we randomly assigned 695 early cancer to watchful waiting or radical followed them through the end of 2012. The primary points in Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) were death from any cause, cancer, risk metastases. Secondary included initiation androgen-deprivation therapy.During 23.2 years...
Radical prostatectomy is widely used in the treatment of early prostate cancer. The possible survival benefit this treatment, however, unclear. We conducted a randomized trial to address question.From October 1989 through February 1999, 695 men with newly diagnosed cancer International Union against Cancer clinical stage T1b, T1c, or T2 were randomly assigned watchful waiting radical prostatectomy. achieved complete follow-up year 2000 blinded evaluation causes death. primary end point was...
<h3>Importance</h3> Estimates of familial cancer risk from population-based studies are essential components prediction. <h3>Objective</h3> To estimate and heritability types in a large twin cohort. <h3>Design, Setting, Participants</h3> Prospective study 80 309 monozygotic 123 382 same-sex dizygotic individuals (N = 203 691) within the registers Denmark, Finland, Norway, Sweden. Twins were followed up median 32 years between 1943 2010. There 50 990 who died any cause, 3804 emigrated lost to...
The incidence of anal cancer has increased in recent decades, particularly among women. To identify underlying risk factors, we conducted a population-based case–control study Denmark and Sweden.
A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size long follow-up time may, however, allow more accurate estimates detailed understanding long-term risk. The objective the study was to assess nationwide cohort comprising 5931 patients who underwent transplantation kidney, liver or other organs during 1970-1997 in Sweden conducted. Complete accomplished through linkage databases. We used comparisons with...
Experiments in animals, international correlation comparisons, and case-control studies support an association between dietary fat intake the incidence of breast cancer. Most cohort do not corroborate association, but they have been criticized for involving small numbers cases, homogeneous intake, measurement errors estimates intake.
Helicobacter pylori infection, now considered to be a cause of gastric cancer, is also strongly associated with and duodenal ulcer disease. The discovery these relations has brought the long-controversial connection between peptic ulcers cancer into focus.We estimated risk stomach in large cohort hospitalized patients or ulcers, as recorded Swedish Inpatient Register 1965 1983. Altogether, 57,936 were followed through 1989, for an average 9.1 years. standardized incidence ratio--the ratio...
Single-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each 17q12 17q24.3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger.We evaluated 16 from regions Swedish population (2893 subjects cancer 1781 control subjects) assessed individual combined of cancer.Multiple were single analysis. When most significant was selected included multivariate analysis, remained...
To examine the risk of breast cancer after non-contraceptive treatment with estrogen, we conducted a prospective study 23,244 women 35 years age or older who had estrogen prescriptions filled in Uppsala region Sweden. During follow-up period (mean, 5.7 years) developed 253 women. Compared other same region, cohort an overall relative 1.1 (95 percent confidence interval, 1.0 to 1.3). The increased duration (P = 0.002), reaching 1.7 nine 2.7). Estradiol (used 56 periods cohort) was associated...
The benefit of radical prostatectomy in patients with early prostate cancer has been assessed only one randomized trial. In 2005, we reported that improved survival compared watchful waiting after a median 8.2 years follow-up. We now report results 3 more follow-up.From October 1, 1989, through February 28, 1999, 695 men clinically localized were randomly assigned to (n = 347) or 348). Follow-up was complete December 31, 2006, histopathologic review and blinded evaluation causes death....
To evaluate hypotheses about the relationship between immune alterations and cancer, several investigators have determined cancer incidence in groups of patients with rheumatoid arthritis (RA), a chronic autoimmune disease. The primary finding has been an increased risk hematopoietic cancers.In this study, we attempted to refine estimates association RA subsequent development specific cancers.We investigated site-specific associated population-based cohort study 11683 Swedish men women...
Background. Recent epidemiologic investigations have suggested an association between increased blood levels of insulin-like growth factor 1 (IGF-1) and risk prostate cancer Our goal was to determine whether exists serum IGF-1 one its binding proteins, factorbinding protein 3 (IGFBP-3), risk. Methods: An immunoradiometric assay used quantify IGFBP-3 in samples as part a populationbased, case-control study Sweden. The population comprised 210 patients with newly diagnosed, untreated 224...
The effect of pregnancy on the risk breast cancer is not clear. We tested hypothesis that increases transiently after but then falls to a level below age-matched nulliparous women.