Frédéric Davi
A5012486639- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Advanced Breast Cancer Therapies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Chronic Myeloid Leukemia Treatments
- Polyomavirus and related diseases
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- T-cell and Retrovirus Studies
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- Phagocytosis and Immune Regulation
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
Sorbonne Université
2016-2025
Pitié-Salpêtrière Hospital
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Inserm
2007-2024
Centre de Recherche des Cordeliers
2014-2024
Université Sorbonne Nouvelle
2022-2024
Université Paris Cité
2007-2023
Sorbonne University Abu Dhabi
2022
Hôpital Charles-Foix
2013-2020
Erasmus MC
2020
Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements for clonality assessment, marker identification quantification minimal residual disease (MRD) in lymphoid neoplasms has been the focus intense research, development application. However, standardization validation a scientifically controlled multicentre setting is still lacking. Therefore, IG/TR assay design, including bioinformatics, was performed within EuroClonality-NGS...
PURPOSE Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as result immunosuppressive therapy. Most B-cell lymphomas associated with Epstein-Barr virus (EBV) infection. We describe morphologically and clinically distinct group PTLD in 11 patients that occurred late after organ transplantation were not EBV. PATIENTS AND METHODS There seven kidney, three heart, one liver transplant (group I). The clinical manifestations, pathologic findings, treatment,...
Organ recipients are at a high risk of post-transplant lymphoproliferative disorders (PTLDs) as complication immunosuppressive therapy. We report the incidence, clinical presentation, pathologic findings, treatment, and outcome for 24 cases PTLD observed our institution.Twenty-four (1.7%) 1,385 organ transplant developed PTLDs. Dosages drugs were reduced in 19 patients. Treatment consisted anti-B-cell monoclonal antibodies (12 patients), and/or chemotherapy (eight or surgery (two...
PURPOSE: Prognostic studies of posttransplantation lymphoproliferative disorders (PTLDs) are hindered by the small number cases at each transplant center. We analyzed prognostic factors and long-term outcome according to clinical manifestations, pathologic features, treatment investigated value non-Hodgkin’s lymphoma International Index (IPI) in 61 patients with PTLD. PATIENTS AND METHODS: studied two institutions who developed PTLD influencing complete remission survival rates. RESULTS: In...
Bing Neel syndrome is a rare disease manifestation of Waldenström's macroglobulinemia that results from infiltration the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe clinical symptoms, as well appropriate laboratory and radiological studies, can aid in diagnosis. The presentation may be very diverse, includes headaches, cognitive deficits, paresis, psychiatric symptoms. present patients with known macroglobulinemia, even absence systemic...
The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 were found to carry ≥ 1 CTRAs. most frequent chromosome breakpoints 13q, followed by 14q, 18q, 17q, 17p; notably, CTRAs involving 13q showed wide spectrum translocation...
The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires responses in their immense variability complexity. Unsurprisingly, analysis interpretation is a highly convoluted task.We thus implemented ARResT/Interrogate, web-based, interactive application. It can organize filter large amounts immunogenetic data by numerous criteria, calculate several relevant statistics, present results the form multiple interconnected...
NF-κB is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within pathway a discovery and validation CLL cohort totaling 315 cases. The most frequently mutated gene was NFKBIE (21/315 cases; 7%), which encodes IκBε, negative regulator normal B cells. Strikingly, 13 these cases carried an identical 4-bp frameshift deletion, resulting truncated...
Hepatitis C virus (HCV) infection increases the risk of B‐cell non‐Hodgkin lymphomas (B‐NHL). Antiviral treatment (AT) can induce hematological responses in patients with marginal zone (MZL). The ANRS HC‐13 Lympho‐C study aimed at a better understanding impact AT on HCV associated B‐NHL. This multicentric enrolled 116 HCV‐positive B‐NHL between 2006 and 2012. Cytological histological samples were collected for centralized review. At lymphoma diagnosis, median age was 61 years gender ratio...