A5027689225- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Immunodeficiency and Autoimmune Disorders
- T-cell and Retrovirus Studies
- Hemoglobinopathies and Related Disorders
- Cutaneous lymphoproliferative disorders research
- T-cell and B-cell Immunology
- Palliative Care and End-of-Life Issues
- Retinoids in leukemia and cellular processes
- Fungal Infections and Studies
- Erythrocyte Function and Pathophysiology
- Neutropenia and Cancer Infections
- Hepatitis C virus research
- Childhood Cancer Survivors' Quality of Life
- Gastrointestinal Tumor Research and Treatment
Kuwait Cancer Control Center
2010-2024
Kuwait University
2013-2024
Hôpital 20 Août
2023
Complejo Hospitalario de Salamanca
2023
Lithuanian Social Research Centre
2023
Ministry of Health
2005-2022
BACKGROUND: Thalassemia major is a common hemoglobinopathy in the Arabian Gulf region. However, limited data are available on frequency of RBC alloimmunization and autoimmunization transfusion‐dependent Arab thalassemia patients. STUDY DESIGN AND METHODS: A total 190 patients were classified as Kuwaiti non‐Kuwaiti Arab. Pretransfusion investigation records reviewed for presence alloantibody autoantibody, age at which was developed. RESULTS: Fifty‐seven (30%) developed alloantibodies. The...
The aim of this study was to assess the effect blood donation modes on prevalence viral markers among Arab first-time donors in Kuwait.Donor ethnic background classified as Kuwaiti nationals and non-Kuwaiti Arabs. A total 26,874 were screened 2002 for following markers: hepatitis C virus antibody (anti-HCV), B surface antigen (HBsAg), anti-hepatitis core (HBc), human immunodeficiency virus-1 -2 (anti-HIV-1 -2), HIV p24, T lymphotropic virus-I -II (anti-HTLVI/II). All samples positive...
Mycosis fungoides (MF) is rare in children and adolescents. This study was aimed to determine the clinicoepidemiologic features of juvenile onset (≤18 yrs) MF Kuwait. Thirty-six adolescents with registered a referral photobiology unit for cutaneous lymphomas between July 1991 June 2009 were included this study. Children observed constitute 16.6% total number patients MF, 97% Arab ethnicity. The age-adjusted incidence rate among population 0.29/100,000 persons/year. Among 36 adolescents, boys...
Mycosis fungoides (MF) is an indolent, most common type of cutaneous T-cell lymphoma (CTCL) with average estimated incidence 0.5 cases per 100,000 persons year in the western world. Although various clinical and epidemiological features are well delineated population, data scarce from our region.To study clinicoepidemiological MF Kuwait.A referral photobiology unit for lymphomas a national dermatology department collaboration three other departments Kuwait cancer center.One hundred...
The incidence of extranodal non-Hodgkin's lymphoma (NHL) is increasing worldwide. epidemiology NHL in the Middle East largely unknown.We evaluated all cases diagnosed at our institutions between 1998 and 2003 according to site presentation their classification into primary nodal using strict criteria. Extranodal early stage were compared terms clinical characteristics treatment outcomes.There 422 January December 2003, among which 97 (23%) nodal, 132 (31%) 193 (46%) disseminated nodal. In...
The aim of this study was to analyze the alloimmunization against red blood cells (RBC) among Kuwaiti population.Retrospective analysis RBC 179,045 patients, pregnant women, and allogeneic donors conducted for period 1992-2001. frequency 24 alloantibody specificities from 1,278 alloimmunized Kuwaitis estimated.The prevalence positive antibody screen in Kuwait 0.49%. five most frequently identified alloantibodies were anti-D (27.3%), anti-E (18.5%), anti-K (15.6%), anti-Le(a) (8.7%),...
Introduction: Prognostic scoring systems are increasingly used in cancer care. One of these is the Palliative Index (PPI) which based on clinical findings. Few studies validated PPI different settings. Our aim was to test predictive value an acute care setting. Methods: Prospective study that included patients with advanced admitted a tertiary center Kuwait. Patients were divided according score into three groups: A (PPI≤3), B (PPI>3– ≤6), and C (>6). Results: The 91 hospitalized patients....
We conducted this study to describe the symptom burden among hospitalized patients with cancer in a Kuwaiti center. Twenty physical symptoms were assessed 45 cancer. The majority (82%) of had an advanced incurable and 42% receiving best supportive care only. median number per patient was 6.4 ± 2.8. most common pain (82%), weakness/fatigue (80%), anorexia (67%), weight loss (49%), dyspnea (42%). Pain distressing 31% patients, followed by (24%) (11%). high prevalence disease demonstrated...
Haploidentical hematopoietic stem-cell transplantation is an alternative transplant strategy for patients without HLA-matched donor. Still, only half of who might benefit from are able to find related or unrelated donor readily available many in need immediate transplantation. Historical experience with haploidentical has been characterised by a high rejection rate, graft-versus-host disease, and transplant-related mortality. Important advances have made this field during the last 20 years....
Abstract Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop UPLC-MS/MS method quantification Bu human plasma. A total 55 with malignancies (n = 34) non- 21) received myeloablative therapy prior HSCT. tandem mass spectrometric developed validated quantify levels these patients. fully over concentration range...
Limb girdle muscular dystrophy type 2 (LGMD2) is a genetically heterogeneous autosomal recessive disorder caused by mutations in 15 known genes. DNA sequencing of all candidate genes can be expensive and laborious, whereas selective approach often fails to provide molecular diagnosis. We aimed efficiently identify pathogenic via homozygosity mapping population which the genetics LGMD2 has not been well characterized. Thirteen consanguineous families containing proband with were recruited...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases that have diverse clinical, pathological, and biological features. Here, it shown primary nodal extranodal DLBCLs differ genomically phenotypically. Using conventional comparative genomic hybridization (CGH), the authors assessed chromosomal aberrations in 18 nodal, 13 extranodal, 5 mixed DLBCLs. The results demonstrate significantly distinct exemplified by gains arms 1p, 7p, 12q24.21-12q24.31, 22q chromosome X loss...
Abstract In chronic lymphocytic leukaemia (CLL), comorbidities assessed by the CLL comorbidity index (CLL-CI) have been associated with outcomes in Western cohorts. We conducted a retrospective analysis of an unselected Middle Eastern cohort newly diagnosed patients seen at Kuwait Cancer Control Center ( n = 300). Compared to studies, these were younger age (median 59) and had higher burden (69% non-low risk CLL-CI). A CLL-CI score was independently significantly shorter event-free survival...
The aim of the present study is to evaluate possible role fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) in management mycosis fungoides (MF).Nineteen patients (mean age, 40.6 years; median age 41 16 males and 3 females) with risk secondary lymph node (LN) involvement (those large cell transformation, tumors, erythroderma, or enlarged LNs on physical examination) were included study. All underwent PET-CT scan by injecting 0.06 mCi/kg F18...