A5068013433- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Renal Transplantation Outcomes and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Autoimmune Bullous Skin Diseases
- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Immune responses and vaccinations
- Transplantation: Methods and Outcomes
- Genetics, Aging, and Longevity in Model Organisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Liver Diseases and Immunity
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Lymphocytic Leukemia Research
Medical University of Sofia
2001-2025
Alexandrovska Hospital
2012-2024
Medical University Plovdiv
2019
University Hospital Dr. Georgi Stranski
2001
T cell-mediated immunity in elderly people is compromised ways reflected the composition of peripheral cell pool. The advent polychromatic flow cytometry has made analysis subsets feasible unprecedented detail.Here we document shifts subset distribution within naïve (N), central memory (CM) and effector (EM) cells defined by CD45RA CCR7 expression elderly, additionally using costimulatory receptors CD27 CD28, as well coinhibitory CD57 KLRG-1, to further dissect these. Although differences...
Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because rate CMV infection increases with age most countries, it has been suggested that drives or at least exacerbates “immunosenescence”. This contention remains controversial was primary subject Third International Workshop on & Immunosenescence which held Cordoba, Spain, 15-16th March, 2012. Discussions focused several main...
Abstract: We report the distribution of genes encoding 11 killer cell immunoglobulin‐like receptors (KIR) and 2 CD94:NKG2 receptors, in 32 Caucasians, 67 Australian Aborigines 59 Vietnamese. The inhibitory activating KIR were found at different frequency three populations. No correlation was between polymorphism HLA specificities tested samples. most significant associations 2DL2 with 2DS2; 2DS3 3DL1 2DS4 all study groups. In Caucasians Vietnamese 2DS2 associated 2DS1with 3DS1. 2DL1 strongly...
An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if antibodies detected posttransplant are predictive chronic graft failure. With newly developed assay, MICA (major histocompatibility complex class I-related chain A) were also measured their effect analyzed. Total 5219 sera from patients who more than 6 months with functioning tested for by enzyme-linked immunosorbent flow...
Vaccination against the SARS-Cov-2 virus is an effective way to protect disease and severe course of COVID-19. Forty-nine fully vaccinated with mRNA vaccines (BNT162b2 or mRNA-1273) SARS-CoV-2 infection-naïve volunteers aged 33-89 were enrolled in study. Evaluation cellular humoral immune response was performed within 1 3 months (T1) 6-9 (T2) after second injection, 2-3 (T3) a booster dose. Additionally, comparative analysis specific status made between two age groups-below 60 (n = 22) over...
‘Immunogenetics of Aging’ is a component that was first included in the 14th International HLA and Immunogenetics Workshop (IHIWS) developed further within 15th Workshop. The aim this to assess impact human leukocyte antigen (HLA) genes, cytokine some innate immunity genes such as killer‐cell immunoglobulin‐like receptors (KIRs) mannose‐binding lectin 2 (MBL2) successful aging their contribution better understanding immune dysfunction old age. Within IHIWS new populations were analysis....
Mutations in the human DNA methyl transferase 3A (DNMT3A) gene are recurrently identified several hematologic malignancies such as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap and acute myeloid leukemia (AML). They have been shown to confer worse prognosis some of these entities. Notably, about 2/3 mutations missense codon R882 gene. We aimed at development validation a novel easily applicable routine practice method...
Autism is a neurodevelopmental disorder of unknown origin that manifests in early childhood. spectrum disorders (ASDs) refer to broader group neurobiological conditions, pervasive developmental disorders. Despite several arguments for strong genetic contribution, the molecular basis most cases remains unexplained. Several studies have reported an association between ASDs and mutations mitochondrial DNA (mtDNA) molecule. In order confirm these causative relationship, we screened 21...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
Aging is an exceptionally complex process that depends on genetic, environmental, and lifestyle factors. Previous studies within the International HLA Immunogenetics Workshop (IHIWS) component “Immunogenetics of Ageing” showed longevity associated with positive selection HLA-DRB1*11- DRB1*16-associated haplotypes, shown to be protective against diseases. Within 18th IHIWS, we aimed investigate relevance telomere length for successful aging its association classical HLAs. In total 957...
Abstract The ‘Immunogenetics of Aging’ is a newly included component within the 14th International HLA and Immunogenetics Workshop. aim this was to determine contribution human leukocyte antigen (HLA), cytokine genes other major histocompatibility complex‐encoded loci successful aging an increased capacity reach extreme limits life span. Two main data sets from four European populations were in study: unrelated healthy elderly individuals ethnically matched young controls, families with...
Pemphigus vulgaris (PV) is an autoimmune bullous dermatosis with uneven geographic distribution and higher incidence in certain populations. In previous studies, a relatively high of PV was reported Bulgaria (0.47/100,000/year) comparable to that other countries. The genetic background considered responsible for the disease susceptibility, multiple reports have proven be HLA-associated condition. aim our study analyze role factors development Bulgaria. HLA genotyping performed 56 patients,...