A5017183785- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Immunodeficiency and Autoimmune Disorders
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Inhalation and Respiratory Drug Delivery
- Helicobacter pylori-related gastroenterology studies
- Regulation of Appetite and Obesity
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- Reproductive System and Pregnancy
- Effects and risks of endocrine disrupting chemicals
- Immunotherapy and Immune Responses
Near East University
2014-2024
ENT and Allergy
2022
Ümraniye Eğitim ve Araştırma Hastanesi
2018
East Asia School of Theology
2018
Pediatrics and Genetics
2016
Marmara University
2004-2014
Istanbul University
2014
Skaraborg Hospital
2000
Centro Sociosanitario Nuestra Señora del Pino
2000
AstraZeneca (Sweden)
2000
Abstract To evaluate the efficacy of specific sublingual immunotherapy (SLIT), we enrolled 15 children with asthma and rhinitis (7 girls, 8 boys,mean ± SD age 11.7 3.3) allergic to house dust mite (HDM) into a double‐blind, placebo‐controlled study. After run‐in period, patients were randomized receive either placebo (n = 7) or SLIT 8) standardized Dermatophagoides pteronyssinus ( D. ) + farinea 50/50 extract. They received increasing doses up 100 index units reactivity (IR) every day for 4...
<i>Objective:</i> To evaluate the clinical outcome and changes in allergen-specific antibodies during sublingual immunotherapy (SLIT) house dust mite (HDM)-allergic asthma patients to compare levels of HDM-allergic before after treatment with that healthy controls. <i>Method:</i> Thirty-one allergic HDM were studied. Patients groups I (n = 17) II 14) received SLIT a standardized <i>Dermatophagoides pteronyssinus </i>plus farinae</i> 50/50 extract for...
Although sublingual immunotherapy (SLIT) is accepted to be a viable alternative of specific‐allergen immunotherapy, the efficacy long‐term SLIT in asthmatic children not well established. The 3 yr addition pharmacotherapy was compared with alone prospective, open, parallel‐group, controlled study. Children asthma aged 4–16 yr, sensitive house dust mite (HDM) were followed up for run‐in period 1 and then grouped as those who would receive + (n = 62) or 28). All patients evaluated based on...
Summary Objective To evaluate the effect of bacillus Calmette–Guérin (BCG) as an adjuvant to specific sublingual immunotherapy (SLIT) on cytokine profile peripheral blood mononuclear cells (PBMCs) and clinical outcome. Methods Thirty‐two children with asthma rhinitis allergic house dust mite (HDM) negative purified protein derivative (PPD) skin test response were enrolled. After a run‐in period 8 weeks, patients randomized receive either SLIT only ( n =16) or one dose BCG immunization before...
Akkoc T, Aydogan M, Yildiz A, Karakoc-Aydiner E, Eifan Keles S, Akin Kavuncuoglu Bahceciler NN, Barlan IB. Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells.Pediatr Allergy Immunol 2010: 21: 1059–1063.© 2010 John Wiley & Sons A/S To determine the optimal time of Bacillus Calmette–Guerin (BCG) for induction Th1 immunity, we measured interferon (IFN)-γ and interleukin (IL)-10 secretion in purified protein derivative (PPD)-stimulated peripheral blood mononuclear cell...
Allergen-specific immunotherapy administered by the subcutaneous route was introduced a century ago and has been shown to be effective in management of allergic rhinitis asthma. More recently, sublingual administration allergen extracts become popular, especially European countries, also demonstrated efficacy respiratory diseases. Both modes during have not only reduce symptoms need for medication, but prevent development additional sensitivities monosensitized patients, as well asthma...
Therapeutic modalities of asthma have not been proved to be successful in reversing the already established chronic changes airways.We aimed determine impact heat-killed Mycobacterium vaccae immunization, a potent Th1 stimulant, on asthma.Newborn BALB/c mice were divided into three groups; M. group received 107 colony-forming units (CFU)/50 micro L subcutaneously days 3, 14 and 42 before development model, whereas control groups saline. Subsequently, administered 10 g/100 ovalbumin (OVA) 43,...
Treatment of recent tuberculosis infection in children aged <2 years is essential, because high risk progression to disease, but diagnosis hindered by the inaccuracy tuberculin skin test (TST). More-accurate T cell-based tests could enhance optimizing interpretation TST results.A total 979 child contacts Istanbul underwent and enzyme-linked immunospot assay. Using results as a reference standard, we assessed effect age bacille Calmette-Guérin (BCG) vaccination on sensitivity specificity TST,...
Bisphenol A (BPA) is an endocrine-disrupting chemical compound that mainly used in industrial products as packaging and plastics. It usually transmits to humans via oral route from food-contact material. BPA has demonstrated be found body fluids with a higher amount of fetal tissues due bio-accumulation. Although it been reported affect the endocrine system, results on thyroid functions newborns are conflicting. The aim present study demonstrate effect different levels cord blood newborns,...
A recently advanced hypothesis suggests that decreased exposure to T-helper (Th) 1-inducing agents causes Th2-biased differentiation in response concomitant allergens. We therefore examined the effect of pre-immunization with killed Mycobacterium bovis and M. vaccae which are known be very potent inducers Thl immune response, on serum IgE ovalbumin (OVA)-sensitized newborn mice. Eighty-four Balb/c mice were divided into four groups immunized intraperitoneally 24 h after birth 50 microl 5 x...
Abstract Aim: To date, cross‐sectional and case–control studies suggest an inverse association between Helicobacter pylori infection atopic diseases, whereas the immunologic basis has not been studied yet. In this study we investigated T helper (Th) cell function in H. pylori‐ infected children compared cytokine responses non‐atopic groups. Methods: The groups was recruited from a cohort of 327 healthy evaluated followed‐up for 6 years to assess natural history infection. Seventy‐four 136...
Background. Although treatment with oral corticosteroids can cause reactivation of latentMycobacterium tuberculosis(TB) infection in purified protein derivative (PPD)-positive individuals no evidence clinical disease, little is known about the effects inhaled this respect. Objective. This study was undertaken to assess whether corticosteroid (CS) therapy reactivates latent TB PPD-positive asthmatic children. Method. We studied 32 PPD skin test-positive (≥10 mm) children [age (mean ± sd), 7.9...
In this cross-sectional study, we aimed to compare anteroposterior (AP) spine and total body bone mineral density (BMD) measurements of children with asthma treated long-term inhaled budesonide (n = 52, mean age 6.4+/-2.2yr, M/F 22/30) (Group I) those asthmatic who had never received treatment corticosteroids II) 22, 6.8+/-2.2, 10/12). Boys girls were comparable for age, weight, height, cumulative corticosteroid (CS) dosage, duration disease (ICS) within each group. The accumulated dosage in...
To cite this article: Baris S, Ozen A, Ercan H, Karakoc‐Aydiner E, Cagan Ozdemir C, Barlan M, Bahceciler NN, IB. Osteoporosis: An ignored complication of CVID. Pediatric Allergy Immunology 2011; 22 : 676–683. Abstract Background: Multiple factors in common variable immunodeficiency (CVID) might interfere with optimal growth and maturation potentially compromise bone health. Methods: We aimed to evaluate mineral density (BMD) patients CVID using dual energy X‐ray absorptiometry (DEXA)...
Congenital isolated adrenocorticotropic hormone deficiency (CIAD) is a rare disease characterized by low (ACTH) and cortisol levels. To date, recurrent pulmonary infections in infancy have not been reported as an accompanying symptom of CIAD.A 7-year-old boy was hospitalized nine times for lower respiratory tract infections. The results all tests the possible causes wheezing were within normal limits. His ACTH levels persistently low. All other pituitary levels, adrenal ultrasound magnetic...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...