A5048817166- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Herbal Medicine Research Studies
- Olfactory and Sensory Function Studies
- Hip disorders and treatments
- Spondyloarthritis Studies and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plant and fungal interactions
- IL-33, ST2, and ILC Pathways
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Gout, Hyperuricemia, Uric Acid
- Legionella and Acanthamoeba research
- TGF-β signaling in diseases
- Congenital Ear and Nasal Anomalies
- Sinusitis and nasal conditions
- Occupational exposure and asthma
- Pregnancy and Medication Impact
- Sarcoidosis and Beryllium Toxicity Research
Lung Institute
2011-2023
Asthma UK
2015-2021
Imperial College London
2010-2020
Medical Research Council
2015-2020
Harefield Hospital
2017-2020
Royal Brompton Hospital
2018-2020
The London College
2014
Marmara University
2006-2013
Hacettepe University
2005
In children, the clinical efficacy and immunological mechanisms of sublingual immunotherapy (SLIT) compared with subcutaneous (SCIT) is still to be elucidated.To compare SLIT, SCIT pharmacotherapy in relation that govern its effect asthmatic/rhinitis children who were sensitized house dust mite (HDM).In this single centre, prospective, randomized, controlled, open labelled, three parallel group trial, 48 patients mono-sensitized HDM randomized receive either SLIT (n=16), (n=16) or alone...
IntroductionThere is no detailed comparison of allergen-specific immunoglobulin responses following sublingual immunotherapy (SLIT) and subcutaneous (SCIT).ObjectiveWe sought to compare nasal systemic timothy grass pollen (TGP)-specific antibody during 2 years SCIT SLIT 1 year after treatment discontinuation in a double-blind, double-dummy, placebo-controlled trial.MethodsNasal fluid serum were obtained yearly (per-protocol population, n = 84). TGP-specific IgA1, IgA2, IgG4, IgG, IgE...
Rationale Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects treatments. Objective To use grass pollen nasal challenge (NAC) to investigate immunotherapy a cross-sectional study. Methods We studied cutaneous responses untreated subjects with seasonal grass-pollen (n = 14) compared immunotherapy-treated allergics 14), plus nonatopic control group 14). Volunteers underwent standardized NAC 2000 biological units timothy (equivalent...
Allergen-specific immunotherapy is a disease-modifying treatment that induces long-term T-cell tolerance.We sought to evaluate the role of circulating CXCR5+PD-1+ T follicular helper (cTFH) and regulatory (TFR) cells following grass pollen subcutaneous (SCIT) sublingual (SLIT) accompanying changes in their chromatin landscape.Phenotype function cTFH were initially evaluated pollen-allergic (GPA) group (n = 28) nonatopic healthy controls (NAC, n 13) by mathematical algorithms developed manage...
BackgroundAlthough sublingual immunotherapy (SLIT) has been demonstrated to be a safe and efficient treatment in children with seasonal allergic rhinitis (AR), there is little evidence on the efficacy of SLIT house-dust-mite (HDM) extract isolated perennial AR.ObjectivesWe sought assess clinical safety HDM-SLIT rhinitis-conjunctivitis mono-sensitized HDM without asthma symptoms.MethodsTwenty-two (aged 5–10 years) AR conjunctivitis symptoms Dermatophagoides pteronyssinus farinae were...
Rationale: Increases in airway smooth muscle, extracellular matrix, and vascularity are prominent features of remodeling asthma, whereas the extent such patients with persistent allergic rhinitis (PAR) is unknown.Objectives: To test hypothesis that upper a feature PAR.Methods: Total nasal symptoms scores, biopsies, Th1 Th2 cytokines from lavage were assessed subjects severe PAR (n = 46) healthy control 19). Angiolymphangiogenesis was examined using immunohistochemistry staining against CD31...
Cat allergen is widely distributed in homes and schools; allergic sensitization common.To develop a model of cat nasal challenge to establish dose-response time-course characteristics investigate local systemic biomarkers inflammation.Nineteen cat-allergic individuals underwent titrated challenge, range 0.243 14.6 μg/mL Fel d1, matched diluent-only provocation. Clinical response 8 h was assessed by symptom scores peak inspiratory flow (PNIF). Nasal fluid collected using polyurethane sponges...
Local tissue eosinophilia and Th2 cytokines are characteristic features of seasonal allergic rhinitis. Airway remodelling is a feature asthma whereas evidence for in rhinitis (AR) conflicting.By use novel human repetitive nasal allergen challenge (RAC) model, we evaluated the relationship between inflammation AR.Twelve patients with moderate-severe AR underwent 5 alternate day challenges diluent which after 4 weeks were followed by grass pollen extract. Nasal symptoms, Th1/Th2 secretion...
Akkoc T, Aydogan M, Yildiz A, Karakoc-Aydiner E, Eifan Keles S, Akin Kavuncuoglu Bahceciler NN, Barlan IB. Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells.Pediatr Allergy Immunol 2010: 21: 1059–1063.© 2010 John Wiley & Sons A/S To determine the optimal time of Bacillus Calmette–Guerin (BCG) for induction Th1 immunity, we measured interferon (IFN)-γ and interleukin (IL)-10 secretion in purified protein derivative (PPD)-stimulated peripheral blood mononuclear cell...
Article The Relationships between Dental Age, Chronological Age and Bone in Turkish Adolescents with Constitutional Delay of Growth was published on August 1, 2006 the journal Journal Pediatric Endocrinology Metabolism (volume 19, issue 8).
T-bet and GATA-3 are transcriptional factors involved in Th1 Th2 cell differentiation, although their concomitant roles at protein levels target organs during human allergic disease have not been assessed.We investigated the expression of nasal cutaneous models (grass-pollen allergen) a model (PPD) responses man.Nasal biopsies were obtained 8 h skin 48 after allergen PPD challenges, respectively, from 10 rhinitics 6 non-atopic controls. T cells assessed using immunofluorescence...
Risk factors related to the outcome of childhood asthma are not yet well established. We aimed investigate long-term for children with determine risk in predicting persistence disease.Sixty-two were evaluated retrospectively at end a 10-year follow-up. Patients asked complete questionnaire requesting clinical information, and underwent physical examination, skin prick testing, pulmonary function test bronchial provocation testing. Immunologic parameters allergen-specific IgE IgG4 levels,...
Although the development of atopy in newborn is determined by a multitude factors, an intense Th1 stimulus early life could be protective facilitating switch away from Th2. Aimed to determine effect single Mycobacterium vaccae (M. vaccae) immunization OVA-sensitized pregnant mice on IL-5 and IFN-γ secretion placental lymphocytes splenocytes offspring.
Occupational asthma (OA) is one of the leading causes pulmonary diseases and has been extensively studied in adults. Childhood employment, a significant problem many developing countries, should be to determine evaluate its effects on psychosocial lung health. In order investigate presence work‐related asthma‐like symptoms OA apprentice adolescent car painters, 72 adolescents between ages 15–20 yr studying Vocational Training Centres Ankara were investigated using questionnaire, function...