A5026752464- Food Allergy and Anaphylaxis Research
- Occupational and environmental lung diseases
- Virus-based gene therapy research
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Reconstructive Surgery and Microvascular Techniques
- Asthma and respiratory diseases
- Mast cells and histamine
- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Respiratory and Cough-Related Research
- Breast Implant and Reconstruction
- Polyomavirus and related diseases
- Radio Astronomy Observations and Technology
- Cosmology and Gravitation Theories
- Parasite Biology and Host Interactions
- Advanced Glycation End Products research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Plant Virus Research Studies
- S100 Proteins and Annexins
- Inflammatory mediators and NSAID effects
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Animal Virus Infections Studies
Marymount University
2024
Immune Tolerance Network
2019-2023
Minneapolis Heart Institute Foundation
2021
University of Hawaii Cancer Center
2013-2017
Cancer Center of Hawaii
2013-2017
University of Hawaiʻi at Mānoa
2013-2017
University of Hawaii System
2013-2017
Ridgeview Medical Center
2016
Mayo Clinic in Arizona
2008-2014
Johns Hopkins University
1989-2014
Monson, J. R. T. M.D.; Weiser, M. Buie, W. D. Chang, G. Rafferty, F. Donald M.D., Chair; Janice Co-chair; Guillem, Jose Council Representative; Boushey, Robin George Feingold, Daniel Fleshner, Philip Genua, Jill Hammond, Kerry Harb, William Hendren, Samantha Herzig, Kaiser, Andreas Larson, David Lee, Sang McCormick, James D.O.; Melton-Meaux, Genevieve Mills, Steven John Moore, Harvey III Perry, Brian Phang, P. Terry Rivadeneira, Ross, Howard Steele, Scott Strong, Ternent, Charles Varma,...
The Cosmology Large Angular Scale Surveyor (CLASS) is an experiment to measure the signature of a gravitationalwave background from inflation in polarization cosmic microwave (CMB). CLASS multi-frequency array four telescopes operating high-altitude site Atacama Desert Chile. will survey 70% sky frequency bands centered at 38, 93, 148, and 217 GHz, which are chosen straddle Galactic-foreground minimum while avoiding strong atmospheric emission lines. This broad coverage ensures that can...
BackgroundOral food challenge (OFC) is the criterion standard to assess peanut allergy (PA), but it involves a risk of allergic reactions unpredictable severity.ObjectiveOur aim was identify biomarkers for severe or low dose threshold during OFC peanut.MethodsWe assessed Learning Early about Peanut Allergy study, Persistance Oral Tolerance and Sensitization study participants by administering basophil activation test (BAT) skin prick (SPT) measuring levels peanut-specific IgE, Arachis...
IntroductionThere is no detailed comparison of allergen-specific immunoglobulin responses following sublingual immunotherapy (SLIT) and subcutaneous (SCIT).ObjectiveWe sought to compare nasal systemic timothy grass pollen (TGP)-specific antibody during 2 years SCIT SLIT 1 year after treatment discontinuation in a double-blind, double-dummy, placebo-controlled trial.MethodsNasal fluid serum were obtained yearly (per-protocol population, n = 84). TGP-specific IgA1, IgA2, IgG4, IgG, IgE...
ABSTRACT The RTS,S/AS02A protein-based vaccine consistently demonstrates significant protection against infection with Plasmodium falciparum malaria and also clinical severe disease in children areas of endemicity. Here we demonstrate rhesus macaques that priming a replication-defective human adenovirus serotype 35 (Ad35) vector encoding circumsporozoite protein (CS) (Ad35.CS), followed by boosting RTS,S an improved MPL- QS21-based adjuvant formulation, AS01B, maintains antibody responses...
Leading hypotheses to explain helminth-mediated protection against autoimmunity postulate that type 2 or regulatory immune responses induced by helminth infections in the host limit pathogenic Th1-driven autoimmune responses. We tested these investigating whether infection with filarial nematode Litomosoides sigmodontis prevents diabetes onset IL-4-deficient NOD mice and depletion absence of T cells, IL-10, TGF-β alters protection. In contrast IL-4-competent mice, failed develop a shift...
Abstract High-mobility group box 1 (HMGB1) is an inflammatory molecule that has a critical role in the initiation and progression of malignant mesothelioma (MM). Aspirin (acetylsalicylic acid, ASA) most widely used nonsteroidal anti-inflammatory drug reduces incidence, metastatic potential mortality many inflammation-induced cancers. We hypothesized ASA may exert anticancer properties MM by abrogating carcinogenic effects HMGB1. Using HMGB1-secreting -non-secreting human cell lines, we...
Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence gathered that C1 through C3 not C5 C9 enhance neutralization virus-antiviral antibody (V-Ab) complexes. C enhancement occurs primarily by agglutination V-Ab complexes virion lysis or attachment large protein molecules to the complex. In this model, binding C1, 4, 2, 3 complex may explain why some viruses concentrate in infect certain cells bearing receptors such as B lymphocytes, macrophages, monocytes.
Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development sustains progression. Moreover, we demonstrated targeting HMGB1 inhibited cell growth motility in vitro, reduced tumor vivo, prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester pyruvic acid, has been shown be effective inhibitor...
The nasolabial fold was analyzed by studying changes with aging in the and adjacent soft-tissue features. Chronologic photographs were obtained from 19 older subjects, taken approximately every 10 years, age 20 to their present age. In a separate phase of study, facial portraits repose smiling young old adult subjects mechanical frame used for setting an objective point reference. Facial landmarks identified depth measurements made anteroposterior direction. Relative lengths selected points...
Abstract Basophils play a key role in the development and effector phases of type 2 immune responses both allergic diseases helminth infections. This study shows that basophils become less responsive to IgE-mediated stimulation when mice are chronically infected with Litomosoides sigmodontis, filarial nematode, Schistosoma mansoni, blood fluke. Although excretory/secretory products from microfilariae L. sigmodontis suppressed vitro, transfer into did not result basophil suppression. Rather,...
We investigated the interplay between genetics and oral peanut protein exposure in determination of immunological response to using targeted intervention LEAP clinical trial. identified an association peanut-specific IgG4 HLA-DQA1*01:02 that was only observed presence sustained exposure. The driven by specific for Ara h 2 component. Once consumption ceased, IgG4-specific attenuated. validated observing expanded epitopes people who carried HLA-DQA1*01:02. Notably, we confirmed previously...
Basophils are increasingly recognized as playing important roles in the immune responses of allergic diseases and helminth infections. One main obstacles to studying basophils has been lack a simple rapid assay measure basophil activation mice.The purpose this study was develop an murine activation.Mouse blood cells were stained with various combinations positive negative markers for basophils--sorted then assessed purity by May-Grünwald staining cytospins. Once flow cytometric strategy...
Abstract Chronic helminth infections induce a type 2 immune response characterized by eosinophilia, high levels of IgE, and increased T cell production cytokines. Because basophils have been shown to be substantial contributors IL-4 in infections, because are capable inducing Th2 differentiation CD4+ cells IgE isotype switching B cells, we hypothesized that function amplify responses chronic infection. To test this, evaluated basophil using the Litomosoides sigmodontis filaria model...