Madhulika G. Varma

ORCID: 0000-0003-1679-926X
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About
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Research Areas
  • Pelvic floor disorders treatments
  • Colorectal Cancer Surgical Treatments
  • Anorectal Disease Treatments and Outcomes
  • Gastrointestinal motility and disorders
  • Diverticular Disease and Complications
  • Colorectal and Anal Carcinomas
  • Colorectal Cancer Screening and Detection
  • Inflammatory Bowel Disease
  • Congenital gastrointestinal and neural anomalies
  • Cardiac, Anesthesia and Surgical Outcomes
  • Surgical site infection prevention
  • Microscopic Colitis
  • COVID-19 and healthcare impacts
  • Enhanced Recovery After Surgery
  • Gastric Cancer Management and Outcomes
  • Gastroesophageal reflux and treatments
  • Stoma care and complications
  • Cancer survivorship and care
  • Urinary Tract Infections Management
  • Urinary Bladder and Prostate Research
  • Colorectal Cancer Treatments and Studies
  • Hernia repair and management
  • Trauma and Emergency Care Studies
  • Intestinal and Peritoneal Adhesions
  • Radiomics and Machine Learning in Medical Imaging

University of California, San Francisco
2013-2024

UCSF Helen Diller Family Comprehensive Cancer Center
2018-2023

Kansai University
2023

The University of Tokyo
2023

Fukushima Medical University
2023

Johns Hopkins University
2023

Kyoto University
2023

Institut de Virologie
2020-2021

Baptist Medical Center Jacksonville
2021

University of Birmingham
2020

PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated total neoadjuvant therapy are limited. METHODS In this prospective, randomized phase II trial, we assessed outcomes 324 stage or III adenocarcinoma induction chemotherapy followed by chemoradiotherapy (INCT-CRT) consolidation (CRT-CNCT) and either mesorectal excision (TME) basis tumor response. Patients both groups received 4 months...

10.1200/jco.22.00032 article EN Journal of Clinical Oncology 2022-04-28

Monson, J. R. T. M.D.; Weiser, M. Buie, W. D. Chang, G. Rafferty, F. Donald M.D., Chair; Janice Co-chair; Guillem, Jose Council Representative; Boushey, Robin George Feingold, Daniel Fleshner, Philip Genua, Jill Hammond, Kerry Harb, William Hendren, Samantha Herzig, Kaiser, Andreas Larson, David Lee, Sang McCormick, James D.O.; Melton-Meaux, Genevieve Mills, Steven John Moore, Harvey III Perry, Brian Phang, P. Terry Rivadeneira, Ross, Howard Steele, Scott Strong, Ternent, Charles Varma,...

10.1097/dcr.0b013e31828cb66c article EN Diseases of the Colon & Rectum 2013-04-11

The American Society of Colon and Rectal Surgeons is dedicated to assuring high-quality patient care by advancing the science, prevention, management disorders diseases colon, rectum, anus. Clinical Practice Guidelines Committee composed members who are chosen because they have demonstrated expertise in specialty colon rectal surgery. This was created lead international efforts defining quality for conditions related accompanied developing based on best available evidence. These guidelines...

10.1097/dcr.0000000000000397 article EN Diseases of the Colon & Rectum 2015-06-07

Indocyanine green fluoroscopy has been shown to improve anastomotic leak rates in early phase trials.We hypothesized that the use of ensure perfusion may decrease after low anterior resection.We performed a 1:1 randomized controlled parallel study. Recruitment 450 1000 patients was planned over 2 years.This multicenter trial.Included were those undergoing resection defined as anastomosis within 10 cm anal verge.Patients underwent standard evaluation tissue versus conjunction with using...

10.1097/dcr.0000000000002007 article ES Diseases of the Colon & Rectum 2021-04-13

This study was designed to estimate the prevalence of, and identify risk factors associated with, fecal incontinence in racially diverse females older than aged 40 years.The Reproductive Risks for Incontinence Study at Kaiser is a population-based of 2,109 randomly selected middle-aged (average age, 56 years). Fecal incontinence, determined by self-report, categorized frequency. Females reported level bother their general quality life. Potential were assessed interview, physical examination,...

10.1007/s10350-006-0535-0 article EN Diseases of the Colon & Rectum 2006-05-05

Steele, Scott R. M.D.; Varma, Madhulika G. Melton, Genevieve B. Ross, Howard M. Rafferty, Janice F. Buie, W. Donald M.D.

10.1097/dcr.0b013e318255815e article EN Diseases of the Colon & Rectum 2012-06-17

Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in proportion of rectal cancer patients a pathological complete response.The purpose this study was to analyze disease-free overall survival.This nonrandomized phase II trial.The conducted at multiple institutions.Four sequential groups stage or III were included.All received 50 Gy radiation concurrent continuous...

10.1097/dcr.0000000000001207 article EN Diseases of the Colon & Rectum 2018-09-06

Diseases of the Colon & Rectum 54(11):p 1339-1346, November 2011. | DOI: 10.1097/DCR.0b013e3182310f75

10.1097/dcr.0b013e3182310f75 article EN Diseases of the Colon & Rectum 2011-10-06

Despite international data indicating that Enhanced Recovery After Surgery (ERAS) programs, which combine evidence-based perioperative strategies, expedite recovery after surgery, few centers have successfully adopted this approach within the U.S. We describe implementation and efficacy of an ERAS program for colorectal abdominal surgery in a tertiary teaching center used multi-modal continuously evolving to implement among all patients undergoing at single hospital University California,...

10.1186/s12871-016-0223-0 article EN cc-by BMC Anesthesiology 2015-12-01

Paquette, Ian M. M.D.; Varma, Madhulika Ternent, Charles Melton-Meaux, Genevieve Rafferty, Janice F. Feingold, Daniel Steele, Scott R. M.D.

10.1097/dcr.0000000000000599 article EN Diseases of the Colon & Rectum 2016-05-04

Purpose: This study was designed to develop and test the validity reliability of Constipation Severity Instrument. Methods: Scale development conducted in two stages: 1) 74 items were generated through a literature review focus groups constipated patients medical providers; 2) preliminary instrument administered 191 103 healthy volunteers. Test-retest group assessed (N = 90). Content, convergent, divergent, discriminant evaluated by using other validated measures performing one-way analysis...

10.1007/s10350-007-9140-0 article EN Diseases of the Colon & Rectum 2008-01-02

This is the second of a two-part summary National Institutes Health conference on fecal incontinence (FI) that summarizes current treatments and identifies research priorities. Conservative medical management consisting patient education, fiber supplements or antidiarrheals, behavioral techniques such as scheduled toileting, pelvic floor exercises restores continence in up to 25% patients. Biofeedback, often recommended first-line treatment after conservative fails, produces satisfaction...

10.1038/ajg.2014.303 article EN The American Journal of Gastroenterology 2014-10-21

PURPOSE: The primary goal of the Surgical Care Improvement Project is to improve quality care by implementing evidence-based health practices that prevent surgical complications. This study was designed test hypothesis an increase in compliance with process measures decreases rate site infections patients undergoing colorectal surgeries. METHODS: A multidisciplinary task force implemented and monitored individual elective resections at a tertiary institution. Individual rates were collected...

10.1007/dcr.0b013e3181ba782a article EN Diseases of the Colon & Rectum 2010-01-01

The gross extent of ulcerative colitis (UC) is a recognized risk factor for the development colitis-related dysplasia and colorectal cancer (CRC). neoplasia associated with microscopic unknown. aim this study was to describe in patients UC-related dysplasia/CRC.All who underwent colectomy at our institution between 1992-2001 dysplasia/CRC were identified. Histological sections from each specimen reviewed location all lesions dysplasia/CRC.Thirty-six identified whom 30 had slides available...

10.1097/00054725-200311000-00002 article EN Inflammatory Bowel Diseases 2003-11-01

Treatments for transsphincteric, cryptoglandular anal fistulas pose risks high recurrence rates and impaired continence. Anal fistula plugs have gained popularity because of reports success without compromising the sphincter. To examine benefit plug, we compared its rate with a standard treatment transsphincteric similar indications, transanal mucosal advancement flap.We examined outcomes all patients who underwent plug repair from July 2005 to December 2006, excluding those Crohn's disease...

10.1007/dcr.0b013e31819d473f article EN Diseases of the Colon & Rectum 2009-04-01

To evaluate the effectiveness and safety of a vaginal bowel-control device pump system for fecal incontinence treatment.Women with minimum four episodes over 2 weeks were fit intravaginal device. Treatment success, defined as 50% or greater reduction incontinent episodes, was assessed at 1 month. Participants invited into an optional extended-wear period another months. Secondary outcomes included symptom improvement measured by Fecal Incontinence Quality Life, Modified Manchester Health...

10.1097/aog.0000000000000639 article EN Obstetrics and Gynecology 2015-02-05

Hypothesis: Selected clinicopathologic characteristics of locally treated rectal cancers

10.1001/archsurg.134.8.863 article EN Archives of Surgery 1999-08-01
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