Dana M. Omer
A5049301598- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Stoma care and complications
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Intestinal and Peritoneal Adhesions
- Obstructive Sleep Apnea Research
- Advanced Radiotherapy Techniques
- Liver Disease Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cardiovascular Disease and Adiposity
- Palliative Care and End-of-Life Issues
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Gastrointestinal Tumor Research and Treatment
- Clinical practice guidelines implementation
Memorial Sloan Kettering Cancer Center
2022-2025
Hackensack Meridian Health
2024
Kettering University
2022-2023
Hackensack University Medical Center
2020-2022
PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated total neoadjuvant therapy are limited. METHODS In this prospective, randomized phase II trial, we assessed outcomes 324 stage or III adenocarcinoma induction chemotherapy followed by chemoradiotherapy (INCT-CRT) consolidation (CRT-CNCT) and either mesorectal excision (TME) basis tumor response. Patients both groups received 4 months...
JCO
Importance Assessing clinical tumor response following completion of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer is paramount to select for watch-and-wait treatment. Objective To assess organ preservation (OP) and oncologic outcomes according grade. Design, Setting, Participants This was secondary analysis the Organ Preservation Patients Rectal Adenocarcinoma trial, a phase 2, nonblinded, multicenter, randomized trial. Randomization occurred between April...
Recent data have demonstrated that in locally advanced rectal cancer (LARC), a total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and increases rates of tumor response compared to chemoradiation (CRT) alone. They further indicate the optimal sequencing TNT involves consolidation (rather than induction) optimize complete rates. Data, largely from retrospective studies, also shown patients clinical (cCR) after may be managed safely watch wait (WW) instead preemptive...
3520 Background: The preliminary results of the OPRA trial demonstrated that a substantial number patients with locally advanced rectal cancer treated total neoadjuvant therapy (TNT) could achieve organ preservation. Although most tumor regrowths seem to occur within first 3 years, longer follow-up is needed assess ongoing risk regrowth. Here, we report long-term preservation rate and oncologic outcomes trial. Methods: A prospective, multi-institutional phase II trial, in which stage or III...
Objective: Assess the significance of enlarged lateral lymph nodes (LLN) for disease recurrence, metastasis, and organ preservation in patients with rectal cancer. Background: Optimal treatment adenocarcinoma involving LLN is subject to debate. Methods: A post hoc analysis OPRA trial, a multicenter study cancer treated total neoadjuvant therapy (TNT) followed by mesorectal excision or watch-and-wait management. We analyzed association visible (LLN+), LLN≥7 mm (short axis) on baseline MRI,...
Importance Patients treated with radiotherapy (RT) for prostate cancer (PC) have increased risk of secondary rectal (SRC) and more limited treatment options. Objective To assess the tumor molecular profile, clinical characteristics, oncologic outcomes SRC after PC compare them those primary (PRC). Design, Setting, Participants This case-control study included patients diagnosed 5 or years RT PRC who were at Memorial Sloan Kettering Cancer Center in New York between February 1, 1994,...
Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the of predict oncologic outcomes and identify imaging features associated residual disease (RD) after TNT. Materials Methods This was secondary analysis Organ Preservation Rectal Adenocarcinoma (OPRA) trial, which randomized...
10 Background: Interest in organ preservation (OP) strategies for rectal cancer (RC) patients persists. The efficacy of long course chemoradiation (LCRT) vs. short radiation therapy (SCRT) relative to OP is unknown. We compared rates between SCRT and LCRT total neoadjuvant (TNT) strategies. Methods: During the COVID-19 pandemic we established an institutional mandate with no exceptions. For comparison, identified RC treated immediately before after period. After completion TNT, were restaged...
28 Background: The success of a watch-and-wait (WW) strategy for rectal cancer relies on restaging endoscopy and MRI to correctly identify true response (TR) neoadjuvant treatment. This secondary analysis the OPRA trial is first study evaluate assessment’s diagnostic performance in large cohort WW patients. Methods: In trial, patients with stage II/III were treated total therapy (TNT) restaged 8±4 weeks post-treatment. Patients clinical complete (cCR) or near (nCR) offered WW; an incomplete...
Abstract Background Prospective randomized trials have not yet identified baseline features predictive of organ preservation in locally advanced rectal cancers treated with total neoadjuvant therapy and a selective watch-and-wait strategy. Methods This was secondary analysis the OPRA trial, which patients stage II–III adenocarcinoma to receive either induction or consolidation therapy. Patients were recommended for mesorectal excision, watch wait based on clinical response at 8 ± 4 weeks...
BACKGROUND: Restaging endoscopy plays a critical role in selecting locally advanced rectal cancer patients who respond to neoadjuvant therapy for nonoperative management. OBJECTIVE: This study evaluated the restaging endoscopic features that best predict presence of residual tumor bowel wall. DESIGN: was post hoc analysis prospective randomized trial. SETTINGS: The Organ Preservation Rectal Adenocarcinoma Trial across 18 institutions with stage II/III adenocarcinoma receive either induction...
3619 Background: Baseline rectal MRI is routinely used for tumor staging, selecting the initial treatment and prognostication of patients with adenocarcinoma. However, associations baseline clinical variables organ preservation (OP) in a prospective randomized trial have not been reported. Methods: Patients staged stage II or III adenocarcinoma treated phase were to either induction chemotherapy (FOLFOX CAPEOX) followed by chemoradiation consolidation recommended total mesorectal excision...
Background: The watch-and-wait strategy provides an opportunity to pursue non-operative management in rectal cancer patients with clinical complete response after neoadjuvant therapy. of those near remains controversial. Objective: We assessed the oncologic outcomes managed by versus total mesorectal excision according Design: Retrospective cohort study. Settings: Comprehensive center New York. Patients: Patients adenocarcinoma diagnosed between January 2006 December 2020. Interventions: A...